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G-Ratio Commentary-Why You've Been Doing It Wrong. [PDF]

ASN Neuro
Fields RD, Dutta DJ.
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Anisotropic properties of the myelin sheath

Acta Histochemica, 1980
Form birefringence curves were determined for fixed (and unfixed rat axons before and after lipid extraction. The total detected birefringence was assumed to be due to the macromolecular array of myelin sheath components (phospholipids, cholesterol, and proteins). Unfixed nerves displayed negative form birefringence.
Alberto Costa Caseiro-Filho, Benedicto de Campos Vidal, Carlos Godo, Maria Luiza S. Mello   +3 more
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Renewal of Phospholipids in the Myelin Sheath

1976
It is apparent from previous work that the major brain phospholipids are synthesized in the endoplasmic reticulum and in vivo are transferred to ‘myelin’ in both developing and mature animals (l). Nevertheless, no transfer of phospholipids from ‘microsomes’ to ‘myelin’ has been demonstrated in vitro (2), after subcellular fractionation, as it has been ...
R. M. Gould, R. M. C. Dawson
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Phagocytosis of myelin sheath fragments by dendrites

Experimental Brain Research, 1987
In serial ultrathin sections of the frog spinal cord, profiles of dendritic appearance were identified that contained myelin fragment inclusions and received synaptic contacts. In a number of cases it could be established that the inclusions were derived from adjacent myelin sheaths.
Antal, Miklós, Székely, György
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Glycoproteins of myelin sheaths

Journal of Molecular Neuroscience, 1997
A growing number of glycoproteins have been identified and characterized in myelin and myelin-forming cells. In addition to the major P0 glycoprotein of compact PNS myelin and the myelin-associated glycoprotein (MAG) in the periaxonal membranes of myelin-forming oligodendrocytes and Schwann cells, the list now includes peripheral myelin protein-22 (PMP-
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Stabilizing the Myelin Sheath

Science, 2001
STKE Schwann cells of the peripheral nervous system express periaxin, a cytosolic protein that contains a PDZ domain, a hallmark of adaptor proteins that assemble macromolecular signaling complexes. Mutations in the human periaxin gene cause the demyelinating neuropathy of Charcot-Marie-Tooth disease, and mice that lack functional periaxin develop a ...
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Galactolipids in the formation and function of the myelin sheath

Microscopy Research and Technique, 1998
Among the most abundant components of myelin are the galactolipids galactocerebroside (GalC) and sulfatide. In spite of this abundance, the roles that these molecules play in the myelin sheath are not well understood. Until recently, our concept of GalC and sulfatide functions had been principally defined by immunological and chemical perturbation ...
Brian Popko, Kinuko Suzuki, Jeffrey L. Dupree   +2 more
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Arrangement of Cholesterol Molecules in the Myelin Sheath

Nature, 1962
POLARIZED light studies1,2 have indicated that most or all lipid moieties of the myelin sheath are radially arranged. Finean3,4 correlated the X-ray diffraction patterns of fresh and lipid-solvent extracted myelin with known data about the form and size of lipid molecules and suggested that a phospholipid-cholesterol complex forms a part of myelin ...
J J Bubis, M Wolman
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Spermidine: A constituent of the myelin sheath?

Neuroscience Letters, 1978
Abstract Spermidine, an aliphatic polyamine present in high concentrations in the white matter, could act as a bivalent ligand stabilizing myelin lamellae. To seek an answer to the title's question, polyamines were extracted from the subcellular fractions of rat brain after intracerebral injection of [14C]putrescine, a precursor of spermidine ...
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