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Calcium control of myelin sheath growth

Nature Neuroscience, 2017
New studies provide compelling evidence that the number and length of myelin sheaths generated by oligodendrocytes in the CNS are controlled by local calcium levels, linking axonal activity to individual myelin sheath formation.
Robert H Miller
openaire   +3 more sources

Biomechanically‐Adapted Immunohydrogels Reconstructing Myelin Sheath for Peripheral Nerve Regeneration

Advanced Healthcare Materials, 2022
Myelin sheath reconstruction plays an important role in peripheral nerve regeneration. But the hindered reconstruction of myelin sheath, due to the inadequate repair phenotypes of macrophages and Schwann cells after peripheral nerve injury, often causes ...
Wang Yifan   +10 more
semanticscholar   +1 more source

Stabilizing the Myelin Sheath

Science, 2001
STKE Schwann cells of the peripheral nervous system express periaxin, a cytosolic protein that contains a PDZ domain, a hallmark of adaptor proteins that assemble macromolecular signaling complexes. Mutations in the human periaxin gene cause the demyelinating neuropathy of Charcot-Marie-Tooth disease, and mice that lack functional periaxin develop a ...
  +4 more sources

Myelin Sheath as a Dielectric Waveguide for Signal Propagation in the Mid‐Infrared to Terahertz Spectral Range

Advanced Functional Materials, 2018
The myelin sheath enables dramatic speed enhancement for signal propagation in nerves. In this work, myelinated nerve structure is experimentally and theoretically studied using synchrotron‐radiation‐based Fourier‐transform infrared microspectroscopy. It
Guozhi Liu   +9 more
semanticscholar   +1 more source

Myelin Sheath-Inspired Hydrogel Electrode for Artificial Skin and Physiological Monitoring.

ACS Nano
Significant advancements in hydrogel-based epidermal electrodes have been made in recent years. However, inherent limitations, such as adaptability, adhesion, and conductivity, have presented challenges, thereby limiting the sensitivity, signal-to-noise ...
Chencong Liu   +8 more
semanticscholar   +1 more source

Glycoproteins of myelin sheaths

Journal of Molecular Neuroscience, 1997
A growing number of glycoproteins have been identified and characterized in myelin and myelin-forming cells. In addition to the major P0 glycoprotein of compact PNS myelin and the myelin-associated glycoprotein (MAG) in the periaxonal membranes of myelin-forming oligodendrocytes and Schwann cells, the list now includes peripheral myelin protein-22 (PMP-
openaire   +2 more sources

Anisotropic properties of the myelin sheath

Acta Histochemica, 1980
Form birefringence curves were determined for fixed (and unfixed rat axons before and after lipid extraction. The total detected birefringence was assumed to be due to the macromolecular array of myelin sheath components (phospholipids, cholesterol, and proteins). Unfixed nerves displayed negative form birefringence.
B, de Campos Vidal   +3 more
openaire   +2 more sources

Donning the Myelin Sheath

Science's STKE, 2006
The myelin sheath electrically insulates axons and makes the conductance of neuronal impulses much more efficient. Chan et al . examined how the Schwann cells begin myelination of an axon. In neuronal cultures, a cell polarity protein, Par-3, localized to where the Schwann cell meets the axon and promoted the ...
openaire   +2 more sources

Evolution of myelin sheaths: Both lamprey and hagfish lack myelin

Neuroscience Letters, 1984
Modern views of agnathan phylogeny consider Petromyzoniformes and Myxiniformes to belong to distinct classes that diverged from a common ancestor at a remote period, perhaps in the lower Cambrian, greater than 600 million years ago. Both are more primitive than elasmobranchs, holocephalans and bony fishes.
T H, Bullock, J K, Moore, R D, Fields
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Morphology of Cryofixed Myelin Sheath

1998
The myelin sheath is formed by concentrically apposed membrane pairs and shows a regularly layered pattern of alternating light lines and dense lines. Observation of cryofixed myelin demonstrated that the structures represent aqueous spaces. All lamellae of the myelin sheath show globular aggregates of particles and these particles are corresponding ...
openaire   +2 more sources

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