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Glycoproteins of myelin sheaths
Journal of Molecular Neuroscience, 1997A growing number of glycoproteins have been identified and characterized in myelin and myelin-forming cells. In addition to the major P0 glycoprotein of compact PNS myelin and the myelin-associated glycoprotein (MAG) in the periaxonal membranes of myelin-forming oligodendrocytes and Schwann cells, the list now includes peripheral myelin protein-22 (PMP-
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Arrangement of Cholesterol Molecules in the Myelin Sheath
Nature, 1962POLARIZED light studies1,2 have indicated that most or all lipid moieties of the myelin sheath are radially arranged. Finean3,4 correlated the X-ray diffraction patterns of fresh and lipid-solvent extracted myelin with known data about the form and size of lipid molecules and suggested that a phospholipid-cholesterol complex forms a part of myelin ...
J J Bubis, M Wolman
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Science, 2001
STKE Schwann cells of the peripheral nervous system express periaxin, a cytosolic protein that contains a PDZ domain, a hallmark of adaptor proteins that assemble macromolecular signaling complexes. Mutations in the human periaxin gene cause the demyelinating neuropathy of Charcot-Marie-Tooth disease, and mice that lack functional periaxin develop a ...
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STKE Schwann cells of the peripheral nervous system express periaxin, a cytosolic protein that contains a PDZ domain, a hallmark of adaptor proteins that assemble macromolecular signaling complexes. Mutations in the human periaxin gene cause the demyelinating neuropathy of Charcot-Marie-Tooth disease, and mice that lack functional periaxin develop a ...
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Galactolipids in the formation and function of the myelin sheath
Microscopy Research and Technique, 1998Among the most abundant components of myelin are the galactolipids galactocerebroside (GalC) and sulfatide. In spite of this abundance, the roles that these molecules play in the myelin sheath are not well understood. Until recently, our concept of GalC and sulfatide functions had been principally defined by immunological and chemical perturbation ...
Brian Popko +2 more
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Spermidine: A constituent of the myelin sheath?
Neuroscience Letters, 1978Abstract Spermidine, an aliphatic polyamine present in high concentrations in the white matter, could act as a bivalent ligand stabilizing myelin lamellae. To seek an answer to the title's question, polyamines were extracted from the subcellular fractions of rat brain after intracerebral injection of [14C]putrescine, a precursor of spermidine ...
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Free radical research, 2015
Oxidative phosphorylation (OXPHOS) is not only the main source of ATP for the cell, but also a major source of reactive oxygen species (ROS), which lead to oxidative stress.
S. Ravera +8 more
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Oxidative phosphorylation (OXPHOS) is not only the main source of ATP for the cell, but also a major source of reactive oxygen species (ROS), which lead to oxidative stress.
S. Ravera +8 more
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Science's STKE, 2006
The myelin sheath electrically insulates axons and makes the conductance of neuronal impulses much more efficient. Chan et al . examined how the Schwann cells begin myelination of an axon. In neuronal cultures, a cell polarity protein, Par-3, localized to where the Schwann cell meets the axon and promoted the ...
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The myelin sheath electrically insulates axons and makes the conductance of neuronal impulses much more efficient. Chan et al . examined how the Schwann cells begin myelination of an axon. In neuronal cultures, a cell polarity protein, Par-3, localized to where the Schwann cell meets the axon and promoted the ...
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Evolution of myelin sheaths: Both lamprey and hagfish lack myelin
Neuroscience Letters, 1984Modern views of agnathan phylogeny consider Petromyzoniformes and Myxiniformes to belong to distinct classes that diverged from a common ancestor at a remote period, perhaps in the lower Cambrian, greater than 600 million years ago. Both are more primitive than elasmobranchs, holocephalans and bony fishes.
Fields Rd, Moore Jk, Theodore H. Bullock
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Morphology of Cryofixed Myelin Sheath
1998The myelin sheath is formed by concentrically apposed membrane pairs and shows a regularly layered pattern of alternating light lines and dense lines. Observation of cryofixed myelin demonstrated that the structures represent aqueous spaces. All lamellae of the myelin sheath show globular aggregates of particles and these particles are corresponding ...
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1981
The presence of a myelin sheath around nerve cell bodies in some sensory ganglia was first mentioned by Wagner (1846, quoted by Munzer 1931) and Bidder (1847). However, these authors did not appreciate the exact meaning of their finding. A little later, Leydig (1851) not only described the myelin sheath enveloping the nerve cell bodies in the ...
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The presence of a myelin sheath around nerve cell bodies in some sensory ganglia was first mentioned by Wagner (1846, quoted by Munzer 1931) and Bidder (1847). However, these authors did not appreciate the exact meaning of their finding. A little later, Leydig (1851) not only described the myelin sheath enveloping the nerve cell bodies in the ...
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