Results 301 to 310 of about 201,896 (346)

Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

Science, 2004
In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information ...
G. V. Michailov, M. Sereda, Bastian G Brinkmann, Tobias M. Fischer, Bernhard Haug, C. Birchmeier, L. Role, Cary Lai, M. Schwab, K. Nave   +9 more
semanticscholar   +1 more source

Myelin sheath decompaction, axon swelling, and functional loss during chronic secondary degeneration in rat optic nerve.

Investigative Ophthalmology and Visual Science, 2012
PURPOSE To examine chronic changes occurring at 6 months following partial optic nerve (ON) transection, assessing optic axons, myelin, and visual function.
Sophie C. Payne, C. Bartlett, A. Harvey, S. Dunlop, Melinda Fitzgerald   +4 more
semanticscholar   +1 more source

Membranous bodies in the myelin sheath of Schwann cells

Cell Biology International Reports, 1980
Electron microscopy of muscle biopsies of patients with paralytic scoliosis and tuberculosis of spines reveals membranous bodies in the myelin sheath of Schwann cells. On the basis of this morphological pattern and indirect biochemical evidence, it is suggested that these bodies were formed by abnormal myelin metabolism.
A.C.M.C. Yau, W.D. Low, N.K. Chin, L. Hsu, E.C. Chew   +4 more
openaire   +3 more sources

Function of tetraspan proteins in the myelin sheath

Current Opinion in Neurobiology, 2000
During the past few years, significant advances have been made in elucidating the mechanisms by which point mutations and altered gene dosages in tetraspan genes cause neurological disease. In addition, several new myelin tetraspans have been identified that are involved in adhesion, molecular trafficking, growth regulation, and migration of ...
openaire   +3 more sources

Adjustment of the myelin sheath to changes in axon caliber

The Anatomical Record, 1972
Abstract“Chronic” axon swellings were produced by applying a snug ligature around the sciatic nerve of rats by the fourteenth postnatal day, allowing the nerve to compress itself by its subsequent growth. The technique results in swelling of the entire myelinated fiber population proximal to the constriction, and in hypoplasia or arrested growth distal
Millicent A. Johnstone, Reinhard L. Friede, Tsutomu Miyagishi   +2 more
openaire   +3 more sources

Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths

Glia, 2016
Mitochondria play several crucial roles in the life of oligodendrocytes. During development of the myelin sheath they are essential providers of carbon skeletons and energy for lipid synthesis. During normal brain function their consumption of pyruvate will be a key determinant of how much lactate is available for oligodendrocytes to export to power ...
Benjamin G. Kopek, Linda H. Bergersen, Koen Vervaeke, Koen Vervaeke, Johanne Egge Rinholm, Johanne Egge Rinholm, David A. Clayton, Timothy A. Brown, Michael R. Tadross, Ariana N. Tkachuk   +9 more
openaire   +3 more sources

THE STAINING OF THE MYELIN SHEATH BY LUXOL DYE TECHNIQUES

Journal of Neuropathology and Experimental Neurology, 1973
The basic mechanisms by which luxol fast blue stains myelin sheaths was studied by experiments directed to elucidating the chemistry of the dye, the nature of the substrate, and the mode of binding of the dye to the substrate. The diphenylguanidine salts of a series of acid dyes were synthesized.
Sylvia Pandolfi, Raymond A. Clasen, R G Simon, A Lesak, I. Laing, R Scott   +5 more
openaire   +2 more sources

The Morphology of the Developing Myelin Sheath

1974
Myelinated axons are present in the peripheral and central nervous systems, and in both, the myelin sheaths have the form of segmented cylindrical tubes. The segments of the sheaths are the internodes and the intervals between them are the nodes of Ranvier.
openaire   +2 more sources

Cell implants reconstruct myelin sheaths

BMJ, 1999
Scientists have succeeded in remyelinating damaged areas of the central nervous system and restoring lost function by transplanting glial cells directly into the spinal cord of animals. This reconstruction feat, until recently thought impossible, raises hopes of finding treatments for diseases with persistent myelin loss, such as multiple sclerosis ...
openaire   +2 more sources

A RAPID METHOD FOR STAINING MYELIN SHEATHS

Archives of Neurology And Psychiatry, 1928
The disadvantage of the present methods for the staining of myelin sheaths—Weigert, Spielmeyer, Loyez, Frankel and others—is that they require days or even weeks for the preparation of the material. The following method can be performed within one hour and can be applied to sections fixed in formaldehyde and frozen or embedded in either celloidin or ...
openaire   +2 more sources