Results 91 to 100 of about 36,763 (214)

Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The majority of L4–L5 dorsal root ganglion cells innervating the triceps surae muscles of healthy rats expressed TRPC6 channels. In decerebrated rats, pharmacological inhibition of TRPC6 channels by injection of antagonists (SAR7334 or BI‐749327) into the arterial supply of the triceps surae muscles inhibited the exercise pressor
Guillaume P. Ducrocq   +5 more
wiley   +1 more source

The physiology, anatomy and stimulation of the vagus nerve in epilepsy

open access: yesThe Journal of Physiology, Volume 603, Issue 8, Page 2201-2217, 15 April 2025.
Abstract figure legend The vagus nerve is both the longest cranial nerve and the largest, providing parasympathetic control of multiple organ systems within the thorax and abdomen, including the cardiovascular, respiratory and gastrointestinal systems (Ottaviani & Macefield, 2022).
Mikaela Patros   +4 more
wiley   +1 more source

Inhibition of ErbB2 mitigates secondary denervation after traumatic muscle injury

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Our study evaluated the therapeutic potential of ErbB2 inhibition (Herceptin) after volumetric muscle loss (VML) injury, primarily evaluating improvements at the neuromuscular junctions (NMJ). A full thickness model of VML injury to the tibialis anterior muscle of adult Lewis rats was used, and treatments included Herceptin, a ...
Jacob R. Sorensen   +6 more
wiley   +1 more source

Cholinergic and Glutamatergic Axons Differentially Require Glial Support in the Drosophila PNS

open access: yesGlia, Volume 73, Issue 7, Page 1365-1382, July 2025.
Main Points In the Drosophila PNS, motor‐ and sensory axons differentially interact with wrapping glia processes. Sensory axons are more weakly associated with wrapping glia and show a length dependent degeneration upon loss of wrapping glia. ABSTRACT In vertebrates, there is a differential interaction between peripheral axons and their associated ...
Steffen Kautzmann   +3 more
wiley   +1 more source

Extensive myelinated nerve fibers in eye with colobomatous optic disk.

open access: yesIndian J Ophthalmol, 2020
Hirawat RS, Nagesha CK, Divakar MM.
europepmc   +1 more source

Disruption of Oligodendroglial Autophagy Leads to Myelin Morphological Deficits, Neuronal Apoptosis, and Cognitive Decline in Aged Mice

open access: yesGlia, Volume 73, Issue 7, Page 1383-1397, July 2025.
Main Points Ablation of autophagy in oligodendrocytes reveals increased PLP expression, myelin abnormalities, axon degeneration and increased microglia activation in aged mice. The aged mice exhibit marked deficits in learning and memory tasks. ABSTRACT The aging central nervous system (CNS) is often marked by myelin degeneration, yet the underlying ...
Niki Ktena   +8 more
wiley   +1 more source

Interpretation of inhomogeneous magnetization transfer in myelin water using a four‐pool model with dipolar reservoirs

open access: yesMagnetic Resonance in Medicine, Volume 94, Issue 1, Page 278-292, July 2025.
Abstract Purpose To confirm ihMT's specificity to myelin, an ihMT presaturation module was combined with a Poon–Henkelman multi‐echo spin‐echo readout to separate the ihMT signal in myelin water from intra‐/extra‐cellular water. This study explored the relationship between two quantitative myelin imaging techniques and measured the ihMT signal of ...
Michelle H. Lam   +7 more
wiley   +1 more source

Efficacy of Mitochondrial Transfer in Healing Toxin‐Induced Damage to Neuromuscular Junction, an Empirical Study

open access: yesSynapse, Volume 79, Issue 4, July 2025.
A neuromuscular junction (NMJ) imaged with pre‐ and postsynaptic features seen with immunofluorescent staining along with confocal microscopy. The article presented here confirms the importance of regaining proper posttraumatic NMJ structure to enable reestablishment of healthy skeletal muscle mass and how the presence of mitochondrial matter promotes ...
Michael R. Deschenes   +7 more
wiley   +1 more source

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