Oligodendrogenesis in Evolution, Development and Adulthood
Oligodendrocytes and myelin took shape in jawed vertebrates. During development, OPCs are originated from NSCs and then undergo differentiation into mature oligodendrocytes that supply myelin. OPCs persist in the adult CNS and continue to produce oligodendrocytes and myelin. Adaptive myelination, which fine‐tunes neural circuits in response to neuronal
Hao Hu+3 more
wiley +1 more source
Morphometric study of the nerve fibers of the oculomotor nerve in dog [PDF]
The intracranial portion of the right oculomotor nerves was extracted from six adult German Shepherd dogs. The nerves were studied using light and electron microscopy.
Agüera Carmona, Eduardo+6 more
core
Brain oligodendrocytes have lower rates of cholesterol synthesis and higher rates of lipoprotein uptake than spinal cord oligodendrocytes. Myelin lipid content is higher in CNS regions with larger average axon diameter. Brain and spinal cord myelin cholesterol content is innately different, while myelin fatty acid content can be modulated by fiber ...
Marie L. Mather+4 more
wiley +1 more source
New Approaches Based on Serial-Block Face Electron Microscopy to Investigate the Peripheral Nervous System. [PDF]
ABSTRACT Background and Aims Serial block face scanning electron microscopy (SBF‐SEM) enables automated 3D imaging of specimens with ultrastructural resolution. However, its application is often restricted due to the complex and labor‐intensive nature of the processes involved.
Borisovs V+4 more
europepmc +2 more sources
AxonDeepSeg: automatic axon and myelin segmentation from microscopy data using convolutional neural networks [PDF]
Segmentation of axon and myelin from microscopy images of the nervous system provides useful quantitative information about the tissue microstructure, such as axon density and myelin thickness. This could be used for instance to document cell morphometry
Antonsanti, Pierre-Louis+5 more
core +3 more sources
With the advantages of high‐resolution imaging, efficient image acquisition, intraoperative real‐time detection, and radiation‐free and noninvasive characteristics, optical coherence tomography (OCT) provides accurate diagnosis and effective intraoperative guidance for the minimally invasive diagnosis and treatment of central nervous system (CNS ...
Jiuhong Li+10 more
wiley +1 more source
The rise of 3D bioprinting advancements in modeling neurodegenerative diseases
Modeling neurodegenerative diseases: 3D bioprinting as a strategy for replicating the complexity of brain architecture. Recent findings have demonstrated that 3D bioprinting platforms can be exploited to recreate the complex neural pattern, giving the possibility of controlling cell density and scaffold stiffness.
Lucia Iafrate, Gianluca Cidonio
wiley +1 more source
On axoplasmic pressure waves and their possible role in nerve impulse propagation
It is suggested that the propagation of the action potential is accompanied by an axoplasmic pressure pulse propagating in the axoplasm along the axon length.
Rvachev, Marat M.
core +1 more source
Neurotrophin-3-enhanced nerve regeneration selectively improves recovery of muscle fibers expressing myosin heavy chains 2b [PDF]
The purpose of this study was to evaluate the effect of neurotrophin 3 (NT-3) enhanced nerve regeneration on the reinnervation of a target muscle. Muscle fibers can be classified according to their mechanical properties and myosin heavy chain (MHC ...
Airaksinen+48 more
core +2 more sources
Nanomaterials for promoting axon regeneration after spinal cord injury: Mechanisms and prospects
The effects of clinical therapies for spinal cord injury (SCI) are greatly limited due to poor axon regeneration. This review systematically discusses the ability of nanomaterials (NMs) to treat SCI and the mechanism underlying their therapeutic effects. The properties of NMs that are conducive to axon regeneration after SCI are outlined.
Jia Liu+9 more
wiley +1 more source