Results 171 to 180 of about 2,285,924 (374)

A phase I/II study of sequential interleukin-3 and granulocyte- macrophage colony-stimulating factor in myelodysplastic syndromes [PDF]

, 1994
Sucha Nand, Jeff Sosman, John E. Godwin, RI Fisher   +3 more
openalex   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Treatment of the anemia of myelodysplastic syndromes using recombinant human granulocyte colony-stimulating factor in combination with erythropoietin [see comments] [PDF]

, 1993
RS Negrin, Ross S. Stein, J. W. Vardiman, Kathleen Doherty, Jordan Cornwell, Susan E. Krantz, PL Greenberg   +6 more
openalex   +1 more source

Revised international prognostic scoring system for myelodysplastic syndromes.

Blood, 2012
P. Greenberg, H. Tuechler, J. Schanz, G. Sanz, G. Garcia-Manero, F. Solé, J. Bennett, D. Bowen, P. Fenaux, F. Dreyfus, H. Kantarjian, A. Kuendgen, A. Levis, L. Malcovati, M. Cazzola, J. Čermák, C. Fonatsch, M. L. Le Beau, M. Slovak, O. Krieger, M. Luebbert, J. Maciejewski, S. Magalhães, Y. Miyazaki, M. Pfeilstöcker, M. Sekeres, W. Sperr, R. Stauder, S. Tauro, P. Valent, T. Vallespí, A. A. van de Loosdrecht, U. Germing, D. Haase   +33 more
semanticscholar   +1 more source

Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)‐rearranged acute leukaemia

British Journal of Pharmacology, EarlyView.
Background and Purpose Activation of Protein Phosphatase 2A (PP2A), via genetic and pharmacologic modulation of SET, has recently being identified as a promising strategy to therapeutically target acute myeloid leukaemia (AML) carrying KMT2A (MLL) chromosomal translocations (KMT2A‐r AML).
Yoana Arroyo‐Berdugo, Antonella Di Mambro, Volker Behrends, Michelle A. Sahai, Luca Cozzuto, Immacolata Zollo, Julia Ponomarenko, Owen Williams, John Gribben, Yolanda Calle, Bela Patel, Maria Teresa Esposito   +11 more
wiley   +1 more source

The evaluation of low-dose cytarabine in the treatment of myelodysplastic syndromes: a phase-III intergroup study [PDF]

, 1993
K B Miller, K. Kyungmann, Francis S. Morrison, Jane N. Winter, John M. Bennett, Richard S. Neiman, David R. Head, Peter A. Cassileth, M J O'Connell   +8 more
openalex   +1 more source

Base editing platform to investigate pathogenic SAMD9 mutations in paediatric myelodysplastic syndromes

British Journal of Haematology, EarlyView.
Gabriele Canciani, Marco Lecis, Giacomo Frati, Valentina D'Agostino, Marta Gelosi, Francesca Del Bufalo, Giuseppe Palumbo, Paolo Palma, Franco Locatelli, Giulia Ceglie   +9 more
wiley   +1 more source

Synergistic Efficacy of Chidamide and LB100 in Sézary Syndrome via TNC Downregulation and PI3K/AKT/mTOR Dephosphorylation

Cancer Science, EarlyView.
Chidamide combined with LB100 can effectively promote the death of Sézary Syndrome by inhibiting the expression of TNC and the phosphorylation of PI3K/AKT/mTOR. ABSTRACT Primary cutaneous T‐cell lymphoma (CTCL) manifests as a distinct variant of T‐cell non‐Hodgkin's lymphoma, predominantly impacting skin tissues and constituting approximately 75%–80 ...
Nan Chen, Yuan Wang, Lan Luo, Xin Hua, Qingfeng Xue, Beiqi Gong, Yaping Zhang, Wenyu Shi   +7 more
wiley   +1 more source

Molecular analysis of chromosome 20q deletions associated with myeloproliferative disorders and myelodysplastic syndromes [PDF]

, 1994
FA Asimakopoulos, NJ White, Elisabeth P. Nacheva, AR Green   +3 more
openalex   +1 more source

Avascular Necrosis and Minimal Trauma Fractures in Telomere Biology Disorders

Clinical Genetics, EarlyView.
Avascular Necrosis (AVN) and Minimal Trauma Fractures (MTF) cause significant morbidity in people with Telomere Biology Disorders (TBDs). They occur more frequently in young patients and in those with autosomal recessive (AR) or X‐linked recessive (XLR) than in autosomal dominant (AD) genotypes.
Arman M. Niknafs, Neelam Giri, Marena R. Niewisch, Sharon A. Savage   +3 more
wiley   +1 more source