Results 201 to 210 of about 51,615 (305)

Avascular Necrosis and Minimal Trauma Fractures in Telomere Biology Disorders

Clinical Genetics, Volume 109, Issue 2, Page 286-293, February 2026.
Avascular Necrosis (AVN) and Minimal Trauma Fractures (MTF) cause significant morbidity in people with Telomere Biology Disorders (TBDs). They occur more frequently in young patients and in those with autosomal recessive (AR) or X‐linked recessive (XLR) than in autosomal dominant (AD) genotypes.
Arman M. Niknafs, Neelam Giri, Marena R. Niewisch, Sharon A. Savage   +3 more
wiley   +1 more source

Progress in the Genetics of Myelodysplastic Syndromes with a Latin American Perspective. [PDF]

Genes (Basel)
Basquiera AL, Andreoli V, Grille S, Belli CB.   +3 more
europepmc   +1 more source

Six‐Year Trends in Real‐World Data Use for Post‐Marketing Surveillance of New Medical Products in Japan

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT The Ministerial Ordinance on Good Post‐Marketing Study Practice for Drugs was amended by the Ministry of Health, Labour and Welfare (MHLW) in 2018 to clearly define post‐marketing database studies (DBS) as a measure of pharmacovigilance activities for approved medical products in Japan.
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Red blood cell transfusion practice and cardiac comorbidities in patients with myelodysplastic syndromes. [PDF]

Transfusion
Mo A, Wood EM, Shortt J, McQuilten ZK.
europepmc   +1 more source

Clinical Utility of Frailty Scoring in Elderly Acute Myeloid Leukemia Patients Treated With Venetoclax and Hypomethylating Agents

European Journal of Haematology, Volume 116, Issue 2, Page 160-168, February 2026.
ABSTRACT Acute myeloid leukemia (AML) in elderly patients presents a major therapeutic challenge, as many are deemed unfit for intensive chemotherapy due to age, comorbidities, or frailty. Venetoclax in combination with hypomethylating agents (HMA) has emerged as a standard‐of‐care for this population, yet outcomes remain heterogeneous and predictive ...
Ernesto Vigna, Antonella Bruzzese, Enrica Antonia Martino, Andrea Corsonello, Santino Caserta, Caterina Labanca, Francesco Mendicino, Eugenio Lucia, Virginia Olivito, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +11 more
wiley   +1 more source

ICSH Recommendations for Monocyte Cell Lineage Morphologic Identification, Nomenclature Harmonization, and Utilization as a Biomarker

International Journal of Laboratory Hematology, Volume 48, Issue 1, Page 12-25, February 2026.
ABSTRACT Monocytes are key components of the Mononuclear Phagocyte System, crucial in immune defense, inflammation, and tissue repair. Accurate identification and classification of monocyte lineage cells are essential for diagnosing both reactive and clonal hematologic disorders.
Gina Zini, Yoon Hwan Chang, Giuseppe d'Onofrio, John Frater, Ulrich Germing, Anna Merino, Olga Pozdnyakova, David Ross, Claudio Romulo Siqueira Filho, Akiyoshi Takami, Erber Wendy   +10 more
wiley   +1 more source

Impact of iron chelation therapy on mitochondrial function, vascular integrity and inflammation in transfusion-dependent myelodysplastic syndromes. [PDF]

Front Immunol
García-Delgado R, Moreno-Carrasco G, Carrasco-Gomariz M, García-Segovia S, Flores RMO, Torres-González J, Gallego-Fuillerat G, López-Villodres JA, Escamilla-Sánchez A.   +8 more
europepmc   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 382-408, 15 January 2026.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Treatment of lower-risk myelodysplastic syndromes. [PDF]

Haematologica
Merz AMA, Platzbecker U.
europepmc   +1 more source

DNA methyltransferase inhibitors in hematological malignancies and solid tumors

International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.
Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger, Guillermo Garcia‐Manero, Robert Zeiser, Michael Lübbert   +3 more
wiley   +1 more source