Results 31 to 40 of about 2,285,924 (374)

Infections in myelodysplastic syndromes

Haematologica, 2012
Myelodysplastic syndromes are associated with a risk of severe infections. While neutropenia is likely to be the main predisposing factor, several other immune defects have been reported, including impaired neutrophil function, B-, T- and NK-cell defects
Andréa Toma, Pierre Fenaux, François Dreyfus, Catherine Cordonnier   +3 more
doaj   +1 more source

Clonal architecture of secondary acute myeloid leukemia [PDF]

, 2012
BACKGROUND: The myelodysplastic syndromes are a group of hematologic disorders that often evolve into secondary acute myeloid leukemia (AML). The genetic changes that underlie progression from the myelodysplastic syndromes to secondary AML are not well ...
Abbott, Rachel, Chen, Ken, Ding, Li, DiPersio, John F, Dooling, David, Eades, William, Fan, Xian, Frater, John L, Fulton, Robert, Graubert, Timothy A, Grillot, Marcus, Heath, Sharon, Kalicki-Veizer, Joelle, Koboldt, Daniel C, Larson, David E, Ley, Timothy J, Link, Daniel C, Magrini, Vincent, Mardis, Elaine R, McLellan, Michael D, O\u27Laughlin, Michelle, Schmidt, Heather, Shao, Jin, Shen, Dong, Tomasson, Michael, Walter, Matthew J, Westervelt, Peter, Wilson, Richard K, Witowski, Sarah   +28 more
core   +2 more sources

TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype.

Blood, 2020
Somatic gene mutations are key determinants of outcome in patients with myelodysplastic syndromes (MDS) and secondary AML (sAML). In particular, patients with TP53 mutations represent a distinct molecular cohort with uniformly poor prognosis. The precise
D. Sallman, Amy F. McLemore, Amy L. Aldrich, R. Komrokji, K. McGraw, A. Dhawan, S. Geyer, H. Hou, E. Eksioglu, A. Sullivan, S. Warren, K. Macbeth, M. Meggendorfer, T. Haferlach, S. Boettcher, B. Ebert, N. Al Ali, J. Lancet, J. Cleveland, E. Padron, A. List   +20 more
semanticscholar   +1 more source

Implementation of erythroid lineage analysis by flow cytometry in diagnostic models for myelodysplastic syndromes

Haematologica, 2017
Flow cytometric analysis is a recommended tool in the diagnosis of myelodysplastic syndromes. Current flow cytometric approaches evaluate the (im)mature myelo-/monocytic lineage with a median sensitivity and specificity of ~71% and ~93%, respectively. We
Eline M.P. Cremers, Theresia M. Westers, Canan Alhan, Claudia Cali, Heleen A. Visser-Wisselaar, Dana A. Chitu, Vincent H.J. van der Velden, Jeroen G. te Marvelde, Saskia K. Klein, Petra Muus, Edo Vellenga, Georgina E. de Greef, Marie-Cecile C.J.C. Legdeur, Pierre W. Wijermans, Marian J.P.L. Stevens-Kroef, Pedro da Silva-Coelho, Joop H. Jansen, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht   +18 more
doaj   +1 more source

Myelodysplastic Syndromes [PDF]

New England Journal of Medicine, 2009
Abstract Session 4 of the 2007 Workshop of the Society for Hematopathology/European Association for Haematopathology was devoted to myelodysplastic syndromes (MDSs). Submitted cases highlighted important issues and difficulties in relation to the diagnosis and classification of MDS.
Ayalew, Tefferi, James W, Vardiman
openaire   +4 more sources

Myelodysplastic syndromes: Aspects of current medical care and economic considerations in Germany [PDF]

, 2008
Myelodysplastic syndromes (MDS) are a heterogeneous group of diseases mainly affecting older people. The use of an increasing number of therapeutic options depends on a systematic risk stratification of the patients.
Berger, Karin, Gattermann, Norbert, Hofmann, Wolf-Karsten, Meeßen, Axel, Plesnila-Frank, Carlotta, Schmitz, Stephan, Schramm, Wolfgang, Tsamaloukas, Anton, Vollmer, Tanja, Wedding, Ulrich   +9 more
core   +1 more source

SF3B1-mutant myelodysplastic syndrome as a distinct disease subtype - A Proposal of the International Working Group for the Prognosis of Myelodysplastic Syndromes (IWG-PM).

Blood, 2020
The 2016 revision of the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues is characterized by a closer integration of morphology and molecular genetics.
L. Malcovati, K. Stevenson, E. Papaemmanuil, D. Neuberg, R. Bejar, J. Boultwood, D. Bowen, P. Campbell, B. Ebert, P. Fenaux, T. Haferlach, M. Heuser, J. Jansen, R. Komrokji, J. Maciejewski, M. Walter, M. Fontenay, G. Garcia-Manero, T. Graubert, A. Karsan, M. Meggendorfer, A. Pellagatti, D. Sallman, M. Savona, M. Sekeres, D. Steensma, S. Tauro, F. Thol, P. Vyas, A. A. van de Loosdrecht, D. Haase, H. Tüchler, P. Greenberg, S. Ogawa, E. Hellstrom-Lindberg, M. Cazzola   +35 more
semanticscholar   +1 more source

Multicentric study underlining the interest of adding CD5, CD7 and CD56 expression assessment to the flow cytometric Ogata score in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

Haematologica, 2015
Although numerous recent publications have demonstrated interest in multiparameter flow cytometry in the investigation of myelodysplastic disorders, it is perceived by many laboratory hematologists as difficult and expensive, requiring a high level of ...
Valérie Bardet, Orianne Wagner-Ballon, Julien Guy, Céline Morvan, Camille Debord, Franck Trimoreau, Emmanuel Benayoun, Nicolas Chapuis, Nicolas Freynet, Cédric Rossi, Stéphanie Mathis, Marie-Pierre Gourin, Andréa Toma, Marie C. Béné, Jean Feuillard, Estelle Guérin   +15 more
doaj   +1 more source

Extramedullary Hematopoiesis in Myelodysplastic Syndromes: A Systematic Literature Review

Hemato, 2022
Extramedullary hematopoiesis is rarely seen in patients with myelodysplastic syndromes, and its clinical characterizations are not well-defined.
Chen Wang, Yiyun Shi
doaj   +1 more source

Biomarkers of leukemia risk: benzene as a model. [PDF]

, 1998
Although relatively rare, leukemias place a considerable financial burden on society and cause psychologic trauma to many families. Leukemia is the most common cancer in children.
Smith, MT, Zhang, L
core   +3 more sources