Results 71 to 80 of about 42,337 (292)

Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients

Haematologica, 2016
The clinical and histopathological distinctions between inherited versus acquired bone marrow failure and myelodysplastic syndromes are challenging.
Siobán B. Keel, Angela Scott, Marilyn Sanchez-Bonilla, Phoenix A. Ho, Suleyman Gulsuner, Colin C. Pritchard, Janis L. Abkowitz, Mary-Claire King, Tom Walsh, Akiko Shimamura   +9 more
doaj   +1 more source

Real‐world clinical experience with NGS‐based chimerism analyses in haematopoietic stem cell transplant patients

British Journal of Haematology, EarlyView.
This study demonstrates the clinical utility of a next‐generation sequencing (NGS)‐based chimerism assay (CASAL) in haematopoietic stem cell transplantation (HSCT). Compared to conventional short tandem repeat (STR) methods, CASAL showed significantly higher marker informativeness, detecting mixed chimerism (MC) below 5% recipient DNA with a median of ...
Jin Ju Kim, Soon Sung Kwon, Yu Jeong Choi, Yehyun Kang, Yu Jin Park, Saeam Shin, Seung‐Tae Lee, Jong Rak Choi   +7 more
wiley   +1 more source

Immunophenotypic analysis of erythroid dysplasia in myelodysplastic syndromes. A report from the IMDSFlow working group

Haematologica, 2017
Current recommendations for diagnosing myelodysplastic syndromes endorse flow cytometry as an informative tool. Most flow cytometry protocols focus on the analysis of progenitor cells and the evaluation of the maturing myelomonocytic lineage.
Theresia M. Westers, Eline M.P. Cremers, Uta Oelschlaegel, Ulrika Johansson, Peter Bettelheim, Sergio Matarraz, Alberto Orfao, Bijan Moshaver, Lisa Eidenschink Brodersen, Michael R. Loken, Denise A. Wells, Dolores Subirá, Matthew Cullen, Jeroen G. te Marvelde, Vincent H.J. van der Velden, Frank W.M.B. Preijers, Sung-Chao Chu, Jean Feuillard, Estelle Guérin, Katherina Psarra, Anna Porwit, Leonie Saft, Robin Ireland, Timothy Milne, Marie C. Béné, Birgit I. Witte, Matteo G. Della Porta, Wolfgang Kern, Arjan A. van de Loosdrecht   +28 more
doaj   +1 more source

Bone marrow transplantation for children with myelodysplastic syndromes [PDF]

, 1989
EC Guinan, NJ Tarbell, Ramana Tantravahi, HJ Weinstein   +3 more
openalex   +1 more source

Efficacy and safety of oral decitabine/cedazuridine in the chronic myelomonocytic leukaemia subpopulations from phase 2 and 3 studies

British Journal of Haematology, EarlyView.
A retrospective analysis of patients with chronic myelomonocytic leukaemia treated with oral decitabine 35 mg + cedazuridine 100 mg suggested favourable outcomes, particularly in higher risk patients. The results provide a rationale for further prospective study of oral decitabine/cedazuridine to identify subgroups of this population who would benefit ...
Michael R. Savona, Olatoyosi Odenike, Gail J. Roboz, Harshad Amin, Amy E. DeZern, Elizabeth A. Griffiths, Kim‐Hien Dao, Amer M. Zeidan, Bhavana Bhatnagar, Rena Buckstein, Brian Leber, Mary‐Margaret Keating, Somedeb Ball, Aram Oganesian, Yuri Sano, Harold N. Keer, Guillermo Garcia‐Manero   +16 more
wiley   +1 more source

Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS)

Haematologica, 2011
Background Anemia is an established negative prognostic factor in myelodysplastic syndromes but the relationship between its degree and clinical outcome is poorly defined.
Luca Malcovati, Matteo G. Della Porta, Corinna Strupp, Ilaria Ambaglio, Andrea Kuendgen, Kathrin Nachtkamp, Erica Travaglino, Rosangela Invernizzi, Cristiana Pascutto, Mario Lazzarino, Ulrich Germing, Mario Cazzola   +11 more
doaj   +1 more source

Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes--a phase I/II trial [PDF]

, 1989
A Ganser, B Volkers, J Greher, Oliver G. Ottmann, F Walther, R Becher, L Bergmann, G Schulz, D Hoelzer   +8 more
openalex   +1 more source

Prognostic factors for allogeneic haematopoietic cell transplantation outcomes in primary refractory acute myeloid leukaemia (2013–2022): A retrospective study by the adult acute myeloid leukaemia working group of the Japanese Society for Transplantation and Cellular Therapy

British Journal of Haematology, EarlyView.
Three‐year overall survival (OS) and leukaemia‐free survival (LFS) rates were 28.5% and 24.4% in allogeneic haematopoietic cell transplantation (HCT) for primary refractory acute myeloid leukaemia from 2013 to 2022 in Japan. Age ≥ 50 years, performance status ≥2, adverse cytogenetics, extramedullary disease at diagnosis and peripheral blood blasts at ...
Takaaki Konuma, Yoshimitsu Shimomura, Shohei Mizuno, Satoshi Yamasaki, Shunsuke Yui, Naoyuki Uchida, Noriko Doki, Masatsugu Tanaka, Satoshi Yoshihara, Tetsuya Eto, Yuta Katayama, Yuna Katsuoka, Masahito Tokunaga, Shuichi Ota, Mamiko Sakata‐Yanagimoto, Kazuya Ishiwata, Yoshinobu Kanda, Toshiro Kawakita, Makoto Onizuka, Junya Kanda, Takahiro Fukuda, Yoshiko Atsuta, Masamitsu Yanada   +22 more
wiley   +1 more source

Impact of the International Prognostic Scoring System cytogenetic risk groups on the outcome of patients with primary myelodysplastic syndromes undergoing allogeneic stem cell transplantation from human leukocyte antigen-identical siblings: a retrospective analysis of the European Society for Blood and Marrow Transplantation-Chronic Malignancies Working Party

Haematologica, 2014
Acquired chromosomal abnormalities are important prognostic factors in patients with myelodysplastic syndromes treated with supportive care and with disease-modifying therapeutic interventions, including allogeneic hematopoietic stem cell transplantation.
Francesco Onida, Ronald Brand, Anja van Biezen, Michel Schaap, Peter A. von dem Borne, Johan Maertens, Dietrich W. Beelen, Enric Carreras, Emilio P. Alessandrino, Liisa Volin, Jürgen H.E. Kuball, Angela Figuera, Jorge Sierra, Jürgen Finke, Nicolaus Kröger, Theo de Witte   +15 more
doaj   +1 more source

Prognostic implications of morphology and karyotype in primary myelodysplastic syndromes [PDF]

, 1986
Jacobs Rh, MA Cornbleet, JW Vardiman, Richard A. Larson, MM Le Beau, JD Rowley   +5 more
openalex   +1 more source