Results 71 to 80 of about 51,615 (305)

Long‐Term Outcomes of Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation for Systemic Sclerosis Patients with Impaired Cardiac Function

Arthritis &Rheumatology, Accepted Article.
Objective High intensity conditioning autologous hematopoietic stem cell transplantation (AHSCT) is standard of care for patients with advanced SSc. The role of reduced intensity conditioning (RIC) prior to AHSCT in this population remains unclear. We conducted this study to determine the long‐term outcomes of RIC AHSCT in SSc patients with cardiac ...
Yonatan Lean, Carrie Richardson, Anthony Esposito, Katy Bedjeti, George E. Georges   +4 more
wiley   +1 more source

Emerging Therapies for the Myelodysplastic Syndromes

Clinical Hematology International, 2019
Despite considerable advances in our understanding of the molecular and epigenetic underpinnings of the myelodysplastic syndromes (MDS), this diverse group of myeloid neoplasms remains a significant clinical challenge.
Jonathan Canaani
doaj   +1 more source

Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics. [PDF]

, 2009
Progress in the management of patients with myelodysplastic syndromes (MDS) has been hampered by the inability to detect cytogenetic abnormalities in 40-60% of cases.
Bueso-Ramos, CE, Estey, EH, Garcia-Manero, G, Gilliland, DG, Heinrichs, S, Issa, J-P, Kantarjian, HM, Kornblau, SM, Kulkarni, RV, Levine, RL, Li, C, Loh, ML, Look, AT, Neuberg, D   +13 more
core   +1 more source

Differing clinical features between Japanese and Caucasian patients with myelodysplastic syndromes:Analysis from the International Working Group for Prognosis of MDS [PDF]

, 2018
Clinical features of myelodysplastic syndromes (MDS) could be influenced by many factors, such as disease intrinsic factors (e.g., morphologic, cytogenetic, molecular), extrinsic factors (e.g, management, environment), and ethnicity.
Andrea Kuendgen, Arber, Arjan A. van de Loosdrecht, Bennett, Bhopal, Chen, Christa Fonatsch, Churpek, David Bowen, Detlef Haase, Di Bernardo, Francesc Solé, Francois Dreyfus, Greenberg, Greenberg, Guillermo Garcia-Manero, Guillermo Sanz, Haferlach, Hagop Kantarjian, Harrell, Heinz Tuechler, Intragumtornchai, Jaroslav Cermak, Jaroslaw Maciejewski, John M. Bennett, Julie Schanz, Kawabata, Kennedy, Lee, Luca Malcovati, Marilyn L. Slovak, Mario Cazzola, Matsuda, Michael Lübbert, Michael Pfeilstöcker, Michelle M. Le Beau, Mikkael A. Sekeres, Neukirchen, Papaemmanuil, Peter L. Greenberg, Peter Valent, Pierre Fenaux, Polprasert, Reinhard Stauder, RollisonDE, Savic, Schanz, Shaffer, Sigrid Machherndl-Spandl, Silvia M.M. Magalhaes, Sudhir Tauro, Suh, Team, Teras, Teresa Vallespi, Ulrich Germing, Valeria Santini, van Spronsen, Vardiman, Voso, Weiss, Wolfgang R. Sperr, World health statistics, Yasushi Miyazaki, Yoshida   +64 more
core   +5 more sources

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, Accepted Article.
Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Clinical activity of azacitidine in patients who relapse after allogeneic stem cell transplantation for acute myeloid leukemia

Haematologica, 2016
Disease relapse is the most common cause of treatment failure after allogeneic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndromes, yet treatment options for such patients remain extremely limited.
Charles Craddock, Myriam Labopin, Marie Robin, Juergen Finke, Patrice Chevallier, Ibrahim Yakoub-Agha, Jean Henri Bourhis, Henrik Sengelov, Didier Blaise, Thomas Luft, Michael Hallek, Nicolaus Kröger, Arnon Nagler, Mohamad Mohty   +13 more
doaj   +1 more source

Será que a soja aumenta as contagens sanguíneas em síndrome mielodisplásica? [PDF]

, 2010
Myelodysplastic syndromes (MDS) are a group of clonal stem cell diseases characterized by ineffective hematopoiesis, bone marrow hyperproliferation, cytopenias in peripheral blood and risk of transformation into acute leukemia.
Atallah, Álvaro Nagib, Carvalho, V. M., Chauffaille, Maria de Lourdes Lopes Ferrari, Claricia, E., Panizzi, M. C. C., Pinheiro, R. F., Sandes, Alex Freire, Sesso, Ricardo de Castro Cintra, Viana, T. A. O. F., Yamamoto, Mihoko   +9 more
core   +2 more sources

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

British Journal of Clinical Pharmacology, EarlyView.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon, Hinke Huisman‐Siebinga, Shelby Barnett, Paul Wetherell, Pamela Kearns, Brenda Gibson, Nicholas Heaney, Owen Smith, André Baruchel, Arnaud Petit, Andrew Moore, Kayode Ogungbenro, Alwin D. R. Huitema, Gareth J. Veal   +13 more
wiley   +1 more source

Familial myelodysplastic syndromes: a review of the literature

Haematologica, 2011
Familial cases of myelodysplastic syndromes are rare, but are immensely valuable for the investigation of the molecular pathogenesis of myelodysplasia in general.
Elena Liew, Carolyn Owen
doaj   +1 more source

Bullous pyoderma gangrenosum and myelodysplastic syndrome [PDF]

, 2006
Pyoderma gangrenosum can present as a cutaneous manifestation of paraneoplastic syndromes. A case of bullous pyoderma gangrenosum associated with bicytopenia is described.
Almeida, Fernando Augusto De, Batista, Mariana Dias, Chauffaille, Maria de Lourdes Lopes Ferrari, Fernandes, Ricardo Limongi, Ikino, Juliana Kida, Michalany, Nílceo Schwery, Pinheiro, Ronald Feitosa, Rocha, Marco Alexandre Dias Da   +7 more
core   +4 more sources