Results 41 to 50 of about 27,191 (241)

Ruxolitinib for myelofibrosis

Experimental and Therapeutic Medicine, 2013
The aim of the present study was to assess the beneficial and harmful effects of ruxolitinib in patients with myelofibrosis (MF). The Cochrane databases, PubMed and Embase were searched for studies published up to October 2012. Randomised controlled trials assessing ruxolitinib versus a placebo or the best available therapy in patients with MF were ...
GU, LIAN, SU, LI, CHEN, QING, XIE, JUANJUAN, WU, GUANGLIANG, YAN, YAN, LIANG, BAOYUN, TAN, JINJING, TANG, NONG   +8 more
openaire   +3 more sources

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

Clinical Pharmacology &Therapeutics, EarlyView.
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet, Sara C. Meyer, Francesco Grandoni, Emmanuel Haefliger, Monika Nagy‐Hulliger, Jörg P. Halter, Jakob R. Passweg, David Haefliger, Carine Bardinet, Laurent A. Decosterd, Monia Guidi, François R. Girardin   +11 more
wiley   +1 more source

Cytogenetics, JAK2 and MPL mutations in polycythemia vera, primary myelofibrosis and essential thrombocythemia

Revista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: The detection of molecular and cytogenetic alterations is important for the diagnosis, prognosis and classification of myeloproliferative neoplasms. OBJECTIVE: The aim of this study was to detect the following mutations: JAK2 V617F, JAK2 exon
Leonardo Caires dos Santos, Juliana Corrêa da Costa Ribeiro, Neusa Pereira Silva, Janete Cerutti, Maria Regina Regis da Silva, Maria de Lourdes Lopes Ferrari Chauffaille   +5 more
doaj   +1 more source

Informative Value of Combination of Molecular Genetic and Cytogenetic Diagnostic Methods in Myelofibrosis

, 2016
Introduction. Myelofibrosis is a rare disease affecting myeloid progenitor stem cells. According to the modern criteria of myelofibrosis diagnostics, the confirmation of the clonality of pathological myeloproliferative process is needed.
Voronyak M., Maslyak Z., Lozynska M., Vygovska Ya., Dmytrenko I., Poluben L., Lozynskyy R.   +6 more
core   +1 more source

Correlation of cytogenetics and grade of bone marrow fibrosis in primary myelofibrosis [PDF]

Srpski Medicinski Časopis Lekarske Komore
Introduction/Aim: Primary myelofibrosis is a clonal myeloproliferative neoplasm characterized by bone marrow fibrosis and extramedullary hematopoiesis.
Đorđević Vesna, Peruničić-Jovanović Maja, Šefer Dijana, Bižić-Radulović Sandra, Soldatović Ivan, Todorović-Balint Milena   +5 more
doaj   +1 more source

The management of myelofibrosis: a British Society for Haematology guideline

, 2023
This document represents an update of the British Society for Haematology guideline on Myelofibrosis first published in 2012 and updated in 2015.1 These guidelines aim to provide healthcare professionals with clear guidance on stratified management for ...
Neelakantan, Pratap, McMullin, Mary Frances, Harrison, Claire N, Somervaille, Tim C.P., Cargo, Catherine, Green, Anna, McMullin, Mary Francis, Brady, Jessica, Garg, Mamta, Cross, Nicholas C.P., Harrison, Claire N., Khan, Alesia, Ewing, Joanne, Nangalia, Jyoti, Francis, Sebastian, McLornan, Donal P, Somervaille, Tim C P, McGregor, Andrew, Lambert, Jonathan, Butt, Nauman M, Woodley, Claire, Innes, Andrew, Psaila, Bethan, Frewin, Rebecca, Cross, Nicholas C P, Godfrey, Anna L, Mead, Adam, Mclornan, Donal P., Butt, Nauman M., Knapper, Steve, Godfrey, Anna L., Arami, Siamak   +31 more
core   +1 more source

Array comparative genomic hybridization and sequencing of 23 genes in 80 patients with myelofibrosis at chronic or acute phase

Haematologica, 2014
Myelofibrosis is a myeloproliferative neoplasm that occurs de novo (primary myelofibrosis) or results from the progression of polycythemia vera or essential thrombocytemia (hereafter designated as secondary myelofibrosis or post-polycythemia vera ...
Mandy Brecqueville, Jérôme Rey, Raynier Devillier, Arnaud Guille, Rémi Gillet, José Adélaide, Véronique Gelsi-Boyer, Christine Arnoulet, Max Chaffanet, Marie-Joelle Mozziconacci, Norbert Vey, Daniel Birnbaum, Anne Murati   +12 more
doaj   +1 more source

The German ONKOPEDIA Guideline for Myelofibrosis in 2025—Recommendations of an MPN Expert Panel of the German Society for Hematology and Oncology (DGHO)

International Journal of Cancer, EarlyView.
ABSTRACT The recently published ONKOPEDIA guideline on myelofibrosis, issued under the auspices of the German Society of Hematology and Oncology (DGHO), provides an updated, evidence‐based framework for the diagnosis and management of this rare, chronic myeloproliferative neoplasm.
Martin Griesshammer, Haifa Kathrin Al‐Ali, Gabriela M. Baerlocher, Konstanze Döhner, Steffen Koschmieder, Nicolaus Kröger, Petro E. Petrides, Dominik Wolf, Florian H. Heidel   +8 more
wiley   +1 more source

Papel de la activación leucocitaria y plaquetaria en la trombosis de los síndromes mieloproliferativos crónicos [PDF]

, 2008
[spa] INTRODUCCIÓN Y OBJETIVOS: La causa fundamental de la trombosis en la policitemia vera y la trombocitemia esencial es el aumento de la viscosidad sanguínea secundaria a la eritrocitosis así como el incremento del número de plaquetas y las ...
Álvarez Larrán, Alberto
core  

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source