Results 81 to 90 of about 60,513 (321)

Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis

Haematologica, 2020
There is prevailing evidence to suggest a decisive role for platelet-derived growth factors (PDGF) and their receptors in primary myelofibrosis. While PDGF receptor β (PDGFRβ) expression is increased in bone marrow stromal cells of patients correlating ...
Frederike Kramer, Jens Dernedde, Artur Mezheyeuski, Rudolf Tauber, Patrick Micke, Kai Kappert   +5 more
doaj   +1 more source

GIPSS: genetically inspired prognostic scoring system for primary myelofibrosis

Leukemia, 2018
International collaborations over the years have produced a series of prognostic models for primary myelofibrosis (PMF), including the recently unveiled mutation-enhanced international prognostic scoring systems for transplant-age patients (MIPSS70 and ...
A. Tefferi, P. Guglielmelli, M. Nicolosi, F. Mannelli, M. Mudireddy, N. Bartalucci, C. Finke, T. Lasho, C. Hanson, R. Ketterling, K. Begna, N. Gangat, A. Pardanani, A. Vannucchi   +13 more
semanticscholar   +1 more source

Myelofibrosis biology and contemporary management

British Journal of Haematology, 2020
Myelofibrosis is an enigmatic myeloproliferative neoplasm, despite noteworthy strides in understanding its genetic underpinnings. Driver mutations involving JAK2, CALR or MPL in 90% of patients mediate constitutive JAK‐STAT signaling which, in concert ...
N. Gangat, A. Tefferi
semanticscholar   +1 more source

Advances in the Management of Myelofibrosis [PDF]

Cancer Control, 2012
Myelofibrosis (MF) is a rare and serious hematologic malignancy classified as a Philadelphia chromosome-negative myeloproliferative neoplasm (MPN). The disease is more common in males and in older individuals. Of the MPNs, MF presents with the most severe morbidity and greatest mortality. Although the cause of MF is unknown, it is thought to occur from
Srdan Verstovsek, Rami S. Komrokji, Alan F. List, Eric Padron   +3 more
openaire   +3 more sources

Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage. [PDF]

, 2018
Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are detected in approximately 40% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF).
Aungier, Juliet, Bennett, Cavan, Dovey, Oliver M, Ghevaert, Cedric, Gonzalez-Arias, Carlos, Green, Anthony R, Grinfeld, Jacob, Hamilton, Tina L, Kent, David G, Klampfl, Thorsten, Li, Juan, Loughran, Stephen, Park, Hyun Jung, Pask, Dean C, Prins, Daniel, Sneade, Rachel, Vassiliou, George S, Williams, Matthew   +17 more
core   +1 more source

Clinical Application of Using Diffusion‐Based Wasserstein Generative Adversarial Network for Morphologic Analysis of Blood Cells

Journal of Clinical Laboratory Analysis, EarlyView.
This study evaluated the accuracy of blood cell classification using 78,494 images across 13 cell classes, demonstrating a significant improvement with the DWGAN‐GP augmented dataset. The use of synthetic images increased the classification accuracy to 97.74%, outperforming both unbalanced data and commercial systems.
Hyun‐Young Kim, Emmanuel Edward Ngasa, Hee‐Jin Kim, Boram Kim, Gyujin Lim, Chang‐Hun Park, Hyeon Jeong Kwon, Mi‐Ae Jang, Jiyoung Woo   +8 more
wiley   +1 more source

European Bone Marrow Working Group trial on reproducibility of World Health Organization criteria to discriminate essential thrombocythemia from prefibrotic primary myelofibrosis

Haematologica, 2012
Background The World Health Organization classification of myeloproliferative neoplasms discriminates between essential thrombocythemia and the prefibrotic phase of primary myelofibrosis.
Thomas Buhr, Konnie Hebeda, Vassiliki Kaloutsi, Anna Porwit, Jon Van der Walt, Hans Kreipe   +5 more
doaj   +1 more source

Survival following allogeneic transplant in patients with myelofibrosis.

Blood Advances, 2020
Allogeneic hematopoietic cell transplantation (HCT) is the only curative therapy for myelofibrosis (MF). In this large multicenter retrospective study, overall survival (OS) in MF patients treated with allogeneic HCT (551 patients) and without HCT (non ...
K. Gowin, K. Ballen, K. Ahn, Zhen-Huan Hu, H. Ali, M. Arcasoy, Rebecca Devlin, M. Coakley, A. Gerds, Michael M Green, Vikas Gupta, G. Hobbs, T. Jain, Malathi Kandarpa, R. Komrokji, A. Kuykendall, K. Luber, L. Masarova, L. Michaelis, Sarah Patches, A. Pariser, R. Rampal, B. Stein, M. Talpaz, S. Verstovsek, M. Wadleigh, Vaibhav Agrawal, M. Aljurf, Miguel Ángel Díaz, B. Avalos, U. Bacher, A. Bashey, A. Beitinjaneh, J. Černý, S. Chhabra, E. Copelan, C. Cutler, Zachariah M DeFilipp, S. Gadalla, S. Ganguly, M. Grunwald, S. Hashmi, M. Kharfan-Dabaja, T. Kindwall‐Keller, N. Kröger, H. Lazarus, J. Liesveld, M. Litzow, D. Marks, S. Nathan, T. Nishihori, R. Olsson, A. Pawarode, J. Rowe, B. Savani, M. L. Savoie, S. Seo, M. Solh, R. Tamari, L. Verdonck, J. Yared, E. Alyea, U. Popat, R. Sobecks, B. Scott, R. Nakamura, R. Mesa, W. Saber   +67 more
semanticscholar   +1 more source

miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis [PDF]

, 2014
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by megakaryocyte (MK) hyperplasia, bone marrow fibrosis, and abnormal stem cell trafficking. PMF may be associated with somatic mutations in JAK2, MPL, or CALR.
Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative, Investigators, Barosi, Giovanni, Bianchi, Elisa, Bisognin, Andrea, Bogani, Costanza, Bortoluzzi, Stefania, Cazzola, Mario, Fanelli, Tiziana, Ferrari, Sergio, Guglielmelli, Paola, Manfredini, Rossella, Mannarelli, Carmela, Norfo, Ruggiero, Pennucci, Valentina, Pietra, Daniela, Prudente, Zelia, Rambaldi, Alessandro, Rontauroli, Sebastiano, Rosti, Vittorio, Ruberti, Samantha, Sacchi, Giorgia, Salati, Simona, Salmoiraghi, Silvia, Tagliafico, Enrico, Vannucchi, Alessandro M, Zini, Roberta   +25 more
core   +1 more source

Systemic Treatment of Moderate to Severe Alopecia Areata in Adults: Updated Australian Expert Consensus Statement

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Over 5000 patients are newly diagnosed with Alopecia areata (AA) in Australia each year. AA severity varies from a single small patch to complete loss of scalp hair, body hair including eyelashes and eyebrows. Approximately 40% of affected individuals experience only a single patch and achieve spontaneous, complete and durable remission within
Daniella Kushnir‐Grinbaum, Laita Bokhari, John Frewen, Anthony Moussa, Daranporn Triwongwaranat, Ragini Ghiya, Flavia Rodrigues Dias, Shin Shen Yong, Bevin Bhoyrul, Zeyad Dabbagh, Ahmed Kazmi, Adam Daunton, Jane Li, Leona Yip, Vivian Lai, Katherine York, William Cranwell, Dmitri Wall, Samantha Eisman, Rodney Sinclair   +19 more
wiley   +1 more source