Results 81 to 90 of about 33,638 (296)

Perspective: Speculative role of Tmp21 mediated protein secretory pathway during endoplasmic reticulum (ER) stress induced chronic inflammation [PDF]

arXiv, 2016
By deploying myelofibrosis as the disease context, I wish to propose that increased availability of Tmp21 (an NFAT gene target) induces aberrant protein secretion from the ER contributing to pathological consequences, which has not been elucidated before.
arxiv  

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms [PDF]

, 2013
n/
Bagienski, Klaudia, Berg, Tiina, Bock, Christoph, Casetti, Ilaria Carola, Cazzola, Mario, Chen, Doris, Cleary, Ciara, Elena, Chiara, Ferretti, Virginia, Gisslinger, Bettina, Gisslinger, Heinz, Harutyunyan, Ashot S., Klampfl, Thorsten, Kralovics, Robert, Malcovati, Luca, Milanesi, Chiara, Milosevic, Jelena D., Nivarthi, Harini, Pascutto, Cristiana, Pietra, Daniela, Rumi, Elisa, Sant'Antonio, Emanuela, Schalling, Martin, Schischlik, Fiorella, Schönegger, Andreas, Six, Melanie, Superti-Furga, Giulio, Them, Nicole C.C., Vladimer, Gregory I.   +28 more
core   +1 more source

Clinical evaluation and outcome in heart failure patients receiving chemotherapy with different anti‐cancer agents

ESC Heart Failure, EarlyView.
Abstract Background The optimal strategy for modern chemotherapy should be based on a comprehensive approach for cancer patients with cardiovascular diseases. Therefore, cardio‐oncology has received increasing attention owing to the cardiotoxic effects of anti‐cancer therapies.
Tomiko Sunaga, Takahiro Okada, Yoshitaka Iso, Mio Ebato, Tsutomu Toshida, Shuichi Nawata, Hiroshi Suzuki, Mari Kogo   +7 more
wiley   +1 more source

Outcome of Transplantation for Myelofibrosis

Biology of Blood and Marrow Transplantation, 2010
Myelofibrosis is a myeloproliferative disorder incurable with conventional strategies. Several small series have reported long-term disease-free survival (DSF) after allogeneic hematopoietic cell transplantation (HCT). In this study, we analyze the outcomes of 289 patients receiving allogeneic transplantation for primary myelofibrosis between 1989 and ...
Theresa Hahn, Smriti Shrestha, Francisco Cervantes, Richard T. Maziarz, William J. Hogan, Mary M. Horowitz, Vikas Gupta, Mukta Arora, Kröger N, Asad Bashey, David I. Marks, Gary J. Schiller, Vivek Roy, Harry C. Schouten, Sergio Giralt, Steven M. Devine, Philip L. McCarthy, Peter H. Wiernik, Kathleen A. Sobocinski, Karen K. Ballen, Mei-Jie Zhang, Robert Peter Gale, Mark R. Litzow, Brian J. Bolwell   +23 more
openaire   +3 more sources

Digital PCR - Methods and Protocols

European Journal of Histochemistry, 2019
Sensitivity, reproducibility, precision and accuracy are recurring words in this book. Indeed, digital PCR (dPCR) represents a major step forward in the quantification of nucleic acids. In this field, for many years it has been used the quantitative PCR (
Paolo Catarsi
doaj   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

CLINICAL AND PATHOMORPHOLOGICAL EXAMINATION OF MYELOFIBROSIS IN CHRONIC MYELOID LEUKEMIA

Сибирский онкологический журнал, 2016
Pathomorphology study of marrow fibrosis in patients with chronic myeloid leukemia was carried out using morphometric image analysis software. It was revealed that every second patient had myelofibrosis.
T. Yu. Dolgikh, I. V. Kachesov, A. A. Marchenko, N. P. Domnikova   +3 more
doaj  

Hematologic and molecular responses to ropeginterferon alfa‐2b therapy of polycythemia vera: 48‐week results from a prospective study

International Journal of Cancer, EarlyView.
What's New? Current treatment goals for polycythemia vera, a myeloproliferative neoplasm characterized by JAK2 mutations, are mainly to prevent thrombosis. While ropeginterferon alfa‐2b treatment also reduces JAK2 mutation burden, the correlation between the hematologic and molecular responses remains to be clarified.
Seug Yun Yoon, Sung‐Soo Yoon, Deok‐Hwan Yang, Gyeong‐Won Lee, Sang Kyun Sohn, Ho‐Jin Shin, Sung Hwa Bae, Chul Won Choi, Eun‐Ji Choi, June‐Won Cheong, Soo‐Mee Bang, Joon Seong Park, Suk Joong Oh, Yong Park, Young Hoon Park, Sung‐Eun Lee   +15 more
wiley   +1 more source

Idiopathic splanchnic vein thrombosis: is it really idiopathic?

Haematologica, 2022
Giovanni Barosi
doaj   +1 more source

Combination therapy with ruxolitinib plus low-dose cytarabine or mercaptopurine in patients with blast-phase myelofibrosis

Онкогематология, 2016
Patients with myelofibrosis in blast-phase commonly have a median overall survival of only 3–6 months. Given the older median age of onset and heavy pretreatment, intensive chemotherapy often is not appropriate and has low efficacy with high toxicity ...
M. S. Fominykh, V. A. Shuvaev, I. S. Martynkevich, L. B. Polushkina, V. Yu. Udal’eva, K. M. Abdulkadyrov   +5 more
doaj   +1 more source