Results 21 to 30 of about 1,006,148 (403)

Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection [PDF]

, 2016
Phosphoinositide-3-kinase (PI3K) is an enzyme group, known to regulate key survival pathways in acute myeloid leukaemia (AML). It generates phosphatidylinositol-3,4,5-triphosphate, which provides a membrane docking site for protein kinaseB activation ...
Alves, Arcaro, Asou, Bouscary, Bouscary, Bouscary, Bowles, Carroll, Carroll, DiPersio, Druker, Esmaeili-Mahani, Finan, Gandhi, Giese, Gilliland, Hirsch, Johnson, Jordan, Kahl, Khwaja, Khwaja, Ko, Konopleva, MacEwan, MacEwan, Niitsu, Pettitt, Pocock, Preudhomme, Recher, Ronnstrand, Rushworth, Solary, Ulrich, Wei, Wymann, Wymann   +37 more
core   +1 more source

YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner.

Blood, 2021
RNA-binding proteins (RBPs) are critical regulators of transcription and translation that are often dysregulated in cancer. Although RBPs are increasingly appreciated as being important for normal hematopoiesis and for hematological malignancies as ...
Mengdie Feng, Xueqin Xie, G-X Han, Tiantian Zhang, Yashu Li, Yicun Li, Rong Yin, Qifan Wang, Tongnian Zhang, Peipei Wang, Jin Hu, Ying Cheng, Zhuying Gao, Jing Wang, Jiwei Chang, Manman Cui, Ke-Ke Gao, Jihua Chai, Weidong Liu, Chengli Guo, Shaoguang Li, Lingbo Liu, F. Zhou, Jianjun Chen, Haojian Zhang   +24 more
semanticscholar   +1 more source

Priapism as the first symptom of chronic myeloid leukemia: literature review and own clinical case report

Онкогематология, 2022
Chronic myeloid leukemia is a ph-positive myeloproliferative disease, which is usually manifested by hyperleukocytosis and massive splenomegaly. Chronic myeloid leukemia is rare in childhood and adolescence, it accounts for 2 to 3 % of all leukemias ...
T. Yu. Pavlova, T. T. Valiev
doaj   +1 more source

Somatic mutations precede acute myeloid leukemia years before diagnosis

Nature Medicine, 2018
Pinkal Desai, Nuria Mencia-Trinchant, Oleksander Savenkov   +2 more
exaly   +2 more sources

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

New England Journal of Medicine, 2013
BACKGROUND Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet clear.
T. Ley, C. Miller, L. Ding, Benjamin J. Raphael, A. Mungall, A. G. Robertson, K. Hoadley, T. Triche, P. Laird, J. Baty, L. Fulton, R. Fulton, S. Heath, Joelle M. Kalicki-Veizer, C. Kandoth, J. Klco, D. Koboldt, K. Kanchi, S. Kulkarni, T. Lamprecht, D. Larson, Ling Lin, Charles Lu, M. McLellan, Joshua F. McMichael, J. Payton, Heather K. Schmidt, D. Spencer, M. Tomasson, J. Wallis, L. Wartman, M. Watson, J. Welch, M. Wendl, Adrian Ally, Miruna Balasundaram, I. Birol, Y. Butterfield, Readman Chiu, Andy Chu, E. Chuah, Hye-Jung E. Chun, R. Corbett, Noreen Dhalla, R. Guin, A. He, Carrie Hirst, M. Hirst, R. Holt, Steven P. Jones, A. Karsan, Darlene Lee, H. Li, M. Marra, Michael Mayo, Richard A. Moore, K. Mungall, J. Parker, E. Pleasance, Patrick Plettner, J. Schein, D. Stoll, Lucas Swanson, Angela Tam, N. Thiessen, R. Varhol, N. Wye, Yongjun Zhao, S. Gabriel, G. Getz, C. Sougnez, L. Zou, Mark D. M. Leiserson, Fabio Vandin, Hsin-Ta Wu, F. Applebaum, S. Baylin, Rehan Akbani, B. Broom, Ken Chen, Thomas C. Motter, Khanh Nguyen, J. Weinstein, Nianziang Zhang, M. Ferguson, C. Adams, Aaron D. Black, Jay Bowen, J. Gastier-Foster, T. Grossman, T. Lichtenberg, L. Wise, Tanja Davidsen, John A. Demchok, K. Shaw, Margi Sheth, H. Sofia, Liming Yang, J. Downing, G. Eley   +99 more
semanticscholar   +1 more source

De novo acute myeloid leukemia: A population‐based study of outcome in the United States based on the Surveillance, Epidemiology, and End Results (SEER) database, 1980 to 2017

Cancer, 2021
Several important treatment and supportive care strategies have been implemented over the past 4 decades in the management of acute myeloid leukemia (AML).
K. Sasaki, F. Ravandi, T. Kadia, C. Dinardo, N. Short, G. Borthakur, E. Jabbour, H. Kantarjian   +7 more
semanticscholar   +1 more source

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia

Haematologica, 2019
Differentiation therapies achieve remarkable success in acute promyelocytic leukemia, a subtype of acute myeloid leukemia. However, excluding acute promyelocytic leukemia, clinical benefits of differentiation therapies are negligible in acute myeloid ...
Jianbiao Zhou, Jessie Yiying Quah, Yvonne Ng, Jing-Yuan Chooi, Sabrina Hui-Min Toh, Baohong Lin, Tuan Zea Tan, Hiroki Hosoi, Motomi Osato, Qihui Seet, A.G. Lisa Ooi, Bertil Lindmark, Mark McHale, Wee-Joo Chng   +13 more
doaj   +1 more source

Safe discontinuation of nilotinib in a patient with chronic myeloid leukemia: a case report [PDF]

, 2014
Case presentation. We report the case of a 64-year-old Caucasian man diagnosed with chronic-phase chronic myeloid leukemia in April 2005. After 4 years of treatment with imatinib, he became intolerant to the drug and was switched to nilotinib.
CAOCCI, GIOVANNI, Greco M, LA NASA, GIORGIO   +2 more
core   +2 more sources

Chronic Myeloid Leukemia: A Model Disease of the Past, Present and Future

Cells, 2021
Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after ...
Valentina R Minciacchi, Rahul Kumar, D. Krause   +2 more
semanticscholar   +1 more source

Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice

Haematologica, 2008
We investigated the NPM1 mutation status or subcellular expression of NPM protein (nuclear vs. aberrant cytoplasmic) at diagnosis and relapse in 125 patients with acute myeloid leukemia from Italy and Germany.
Brunangelo Falini, Maria Paola Martelli, Cristina Mecucci, Arcangelo Liso, Niccolò Bolli, Barbara Bigerna, Alessandra Pucciarini, Stefano Pileri, Giovanna Meloni, Massimo F. Martelli, Torsten Haferlach, Susanne Schnittger   +11 more
doaj   +1 more source