Results 41 to 50 of about 414,323 (331)

Increased plasma viscosity as a reason for inappropriate erythropoietin formation [PDF]

, 1993
The aim of this study was to examine whether altered plasma viscosity could contribute to the inappropriately low production rate of erythropoietin (EPO) observed in patients suffering from hypergammaglobulinemias associated with multiple myeloma or ...
Eckardt, Kai-Uwe, Götz, Karlheinz, Hamann, M., Kurtz, Armin, Ratcliffe, P. J., Reinhart, W. H., Singh, A., Zimmermann, A.   +7 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Multiple Myeloma : an update on disease biology and therapy [PDF]

, 2004
Multiple myeloma is a malignancy of immunoglobulin producing plasma cells. Clinical features include bone pain due to lytic bone lesions or pathological fractures, anemia, symptomatic hypercalcemia, renal insufficiency, recurrent infections and ...
Cook, Rachel J., Dingli, David
core  

Living with multiple myeloma: A focus group study of unmet needs and preferences for survivorship care [PDF]

, 2017
Purpose: To describe the unmet informational, psychological, emotional, social, practical, and physical needs and preferences for posttreatment survivorship care of individuals living with multiple myeloma to inform the development of relevant ...
Bulsara, C, Joske, D, Krishnasamy, M, Lobb, E, Monterosso, L, Musiello, T, Platt, V, Stratton, K, Taylor, K   +8 more
core   +3 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Post-Transplant Outcomes in High-Risk Compared with Non-High-Risk Multiple Myeloma: A CIBMTR Analysis. [PDF]

, 2016
Conventional cytogenetics and interphase fluorescence in situ hybridization (FISH) identify high-risk multiple myeloma (HRM) populations characterized by poor outcomes.
Amer Beitinjaneh, Amrita Krishnan, Anita D'Souza, Attal, Avet-Loiseau, Avet-Loiseau, Avet-Loiseau, Baldeep Wirk, Bipin N. Savani, Boyd, Boyd, Chang, Chng, Chng, Cindy Lee, Cristina Gasparetto, Dan Vogl, David Vesole, Emma C. Scott, Fonseca, Fonseca, Fonseca, Gerhard Hildebrandt, Hanamura, Hari, Harousseau, Hebraud, Henry Fung, Hillard Lazarus, Jason Tay, Jean Yared, Jennifer Le-Rademacher, Jiaxing Huang, Joseph Mikhael, Kapoor, Kenneth Meehan, Leona Holmberg, Manish Sharma, Matt Kalaycio, Muneer Abidi, Munshi, Muthalagu Ramanathan, Neben, Nooka, Palumbo, Parameswaran Hari, Richard T. Maziarz, Robert Kyle, Saad Usmani, Shaji Kumar, Shaughnessy, Siddhartha Ganguly, Sonneveld, Taiga Nishihori, Tomer Mark, Usmani, Yago Nieto   +56 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

A novel two-step administration of XPO-1 inhibitor may enhance the effect of anti-BCMA CAR-T in relapsed/refractory extramedullary multiple myeloma [PDF]

, 2023
Di Wang, Haiying Fu, Yimei Que, Haitao Ruan, Menglei Xu, Xiaolu Long, Qiuxia Yu, Chunhui Li, Zhe Li, Songbai Cai, Wei Chen, Cong Sun, Guang Hu, Shuai Wang, Donggou He, Jianming Mei, Wen Wang, Chunrui Li   +17 more
openalex   +1 more source

Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging [PDF]

, 2008
Two novel polyarginine labelled ruthenium polypyridyl dyes are reported, one conjugated to five, (Ru-Ahx-R5), and one to eight arginine residues, (Ru-Ahx-R8). Both complexes exhibit long-lived, intense, and oxygen sensitive luminescence.
Amoroso, Aylward, Bai, Brunner, Dobrucki, Fischer, Fuchs, Fuchs, Fulda, Futaki, Kale, Kielar, Kielar, Lakowicz, Lissi, Lo, Marc Devocelle, Mendoza, Mendoza, Murray, Musatkinaa, Niamh Moran, Pellegrin, Robert J. Forster, Santra, Tia E. Keyes, Ute Neugebauer, William Signac, Xu, Yann Pellegrin, Zhang, Zhong, Zhong   +32 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source