Results 1 to 10 of about 5,867,860 (378)

The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival [PDF]

Journal of Biological Chemistry, 2019
The Maf proteins, including c-Maf, MafA, and MafB, are critical transcription factors in myelomagenesis. Previous studies demonstrated that Maf proteins are processed by the ubiquitin–proteasome pathway, but the mechanisms remain elusive.
Yuanming He, Siyu Wang, Jiefei Tong, Shuoyi Jiang, Ye Yang, Zubin Zhang, Yujia Xu, Yuanying Zeng, Biyin Cao, Michael F. Moran, Xinliang Mao   +10 more
openalex   +2 more sources

IMMUNOLOGICAL RELATIONSHIPS AMONG THE MYELOMA PROTEINS [PDF]

The Journal of Experimental Medicine, 1955
An immunological study of 21 myeloma sera was carried out to determine their relationship to components of normal γ-globulin and to each other. Ten proteins were separated for detailed characterization.
Robert J. Slater, S. M. Ward, H. G. Kunkel   +2 more
semanticscholar   +3 more sources

Dysregulated immune proteins in plasma in the UK Biobank predict multiple myeloma 12 years before clinical diagnosis. [PDF]

Blood Adv
Fieggen J, Thakur A, Butler CC, Ramasamy K, Thakurta A, Clifton DA, Clifton L.   +6 more
europepmc   +3 more sources

Mass spectrometry for the evaluation of monoclonal proteins in multiple myeloma and related disorders: an International Myeloma Working Group Mass Spectrometry Committee Report

Blood Cancer Journal, 2021
Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect and isotype M-proteins ...
D. Murray, N. Puig, S. Kristinsson, S. Usmani, A. Dispenzieri, G. Bianchi, Shaji K. Kumar, W. Chng, R. Hájek, B. Paiva, A. Waage, S. Rajkumar, B. Durie   +12 more
semanticscholar   +1 more source

Disruption of Proteostasis by Natural Products and Synthetic Compounds That Induce Pervasive Unfolding of Proteins: Therapeutic Implications

Pharmaceuticals, 2023
Exposure of many cancer cells, including multiple myeloma cells, to cytotoxic concentrations of natural products celastrol and withaferin A or synthetic compounds of the IHSF series resulted in denaturation of a luciferase reporter protein.
Nuria Vilaboa, Juan Antonio Lopez, Marco de Mesa, Clara Escudero-Duch, Natalie Winfield, Melanie Bayford, Richard Voellmy   +6 more
doaj   +1 more source

Structural evidence for independent joining region gene in immunoglobulin heavy chains from anti-galactan myeloma proteins and its potential role in generating diversity in complementarity-determining regions

Proceedings of the National Academy of Sciences of the United States of America, 1979
D. Narayana Rao, Stuart Rudikoff, Henry C. Krutzsch, Michael Potter   +3 more
openalex   +3 more sources

Integrative Analysis of Proteomics and Transcriptomics Reveals Endothelin Receptor B as Novel Single Target and Identifies New Combinatorial Targets for Multiple Myeloma

HemaSphere, 2023
Despite the recent introduction of next-generation immunotherapeutic agents, multiple myeloma (MM) remains incurable. New strategies targeting MM-specific antigens may result in a more effective therapy by preventing antigen escape, clonal evolution, and
Margaux Lejeune, Murat Cem Köse, Mégane Jassin, Marie-Jia Gou, Amaury Herbet, Elodie Duray, Gaël Cobraiville, Jacques Foguenne, Didier Boquet, André Gothot, Yves Beguin, Marianne Fillet, Jo Caers   +12 more
doaj   +1 more source

Stroma-Mediated Resistance to S63845 and Venetoclax through MCL-1 and BCL-2 Expression Changes Induced by miR-193b-3p and miR-21-5p Dysregulation in Multiple Myeloma

Cells, 2021
BH3-mimetics targeting anti-apoptotic proteins such as MCL-1 (S63845) or BCL-2 (venetoclax) are currently being evaluated as effective therapies for the treatment of multiple myeloma (MM).
Esperanza M. Algarín, Dalia Quwaider, Francisco J. Campos-Laborie, Andrea Díaz-Tejedor, Pedro Mogollón, Elena Vuelta, Montserrat Martín-Sánchez, Laura San-Segundo, Lorena González-Méndez, Norma C. Gutiérrez, Ramón García-Sanz, Teresa Paíno, Javier De Las Rivas, Enrique M. Ocio, Mercedes Garayoa   +14 more
doaj   +1 more source

ILF2 enhances the DNA cytosine deaminase activity of tumor mutator APOBEC3B in multiple myeloma cells

Scientific Reports, 2022
DNA cytosine deaminase APOBEC3B (A3B) is an endogenous source of mutations in many human cancers, including multiple myeloma. A3B proteins form catalytically inactive high molecular mass (HMM) complexes in nuclei, however, the regulatory mechanisms of ...
Yasuhiro Kazuma, Kotaro Shirakawa, Yusuke Tashiro, Hiroyuki Yamazaki, Ryosuke Nomura, Yoshihito Horisawa, Suguru Takeuchi, Emani Stanford, Yoshinobu Konishi, Hiroyuki Matsui, Tadahiko Matsumoto, Fumiko Tanabe, Ryo Morishita, Shinji Ito, Akifumi Takaori-Kondo   +14 more
doaj   +1 more source

Myeloma Proteins, Bence Jones Proteins and Normal Immunoglobulins in Multiple Myeloma [PDF]

Blood, 1967
Abstract The relationship between the anomalous and normal immunoglobulins was studied through measurement of myeloma protein (MP), Bence Jones protein (BJP), and the normal γG, γA, γM and γD-globulin levels in a large group of patients with multiple myeloma. These determinations were made prior to and after initiation of three different
V, Caggiano, J, Cuttner, A, Solomon
openaire   +2 more sources