Results 11 to 20 of about 5,867,860 (378)

Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma. [PDF]

New England Journal of Medicine, 2019
BACKGROUND Selinexor, a selective inhibitor of nuclear export compound that blocks exportin 1 (XPO1) and forces nuclear accumulation and activation of tumor suppressor proteins, inhibits nuclear factor κB, and reduces oncoprotein messenger RNA ...
A. Chari, D. Vogl, M. Gavriatopoulou, Ajay K Nooka, Andrew J Yee, Carol A. Huff, P. Moreau, D. Dingli, C. Cole, S. Lonial, M. Dimopoulos, A. Stewart, J. Richter, R. Vij, S. Tuchman, Marc-Steffen Raab, K. Weisel, M. Delforge, Robert F. Cornell, David Kaminetzky, James E Hoffman, Luciano J. Costa, Terri L. Parker, M. Levy, M. Schreder, N. Meuleman, L. Frenzel, M. Mohty, S. Choquet, G. Schiller, R. Comenzo, M. Engelhardt, T. Illmer, P. Vlummens, C. Doyen, T. Facon, L. Karlin, A. Perrot, K. Podar, M. Kauffman, S. Shacham, Lingling Li, Shijie Tang, Carla Picklesimer, J. Saint-Martin, Marsha L. Crochiere, Hua Chang, S. Parekh, Y. Landesman, J. Shah, Paul G. Richardson, S. Jagannath   +51 more
semanticscholar   +3 more sources

Myeloma protein kinetics following chemotherapy [PDF]

Blood, 1982
The effects of chemotherapy were evaluated in 43 multiple myeloma patients with high monoclonal globulin levels in both serum and urine. In responding patients, Bence Jones protein excretion declined more rapidly and markedly than the serum myeloma protein.
P, McLaughlin, R, Alexanian
openaire   +3 more sources

Pleural effusion as first extra-medullary clinical presentation of an occult multiple myeloma: The role of medical thoracoscopy

Respiratory Medicine Case Reports, 2020
Multiple myeloma is a malignant neoplasm of plasma cells that usually invades the bone marrow replacing normal bone marrow and producing large amounts of light chains of immunoglobulins (Ig) [1]. Clinical manifestations are related to the accumulation of
Antonietta Coppola, Giacomo Ghinassi, Giuseppina Ciarleglio, Uberto Maccari, Laura Salerno, Elena Torricelli, Valentina Granese, Maria Lucia Valentini, Alessandro Sanduzzi Zamparelli, Valerio Torre, Raffaele Scala   +10 more
doaj   +1 more source

A novel nano-immunoassay method for quantification of proteins from CD138-purified myeloma cells: biological and clinical utility

Haematologica, 2018
Protein analysis in bone marrow samples from patients with multiple myeloma has been limited by the low concentration of proteins obtained after CD138+ cell selection.
Irena Misiewicz-Krzeminska, Luis Antonio Corchete, Elizabeta A. Rojas, Joaquín Martínez-López, Ramón García-Sanz, Albert Oriol, Joan Bladé, Juan-José Lahuerta, Jesús San Miguel, María-Victoria Mateos, Norma C. Gutiérrez   +10 more
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Analysis of the Targets and Glycosylation of Monoclonal IgAs From MGUS and Myeloma Patients

Frontiers in Immunology, 2020
Previous studies showed that monoclonal immunoglobulins G (IgGs) of “monoclonal gammopathy of undetermined significance” (MGUS) and myeloma were hyposialylated, thus presumably pro-inflammatory, and for about half of patients, the target of the ...
Adrien Bosseboeuf, Célia Seillier, Nicolas Mennesson, Sophie Allain-Maillet, Maeva Fourny, Anne Tallet, Eric Piver, Eric Piver, Philippe Lehours, Philippe Lehours, Francis Mégraud, Francis Mégraud, Laureline Berthelot, Jean Harb, Jean Harb, Jean Harb, Edith Bigot-Corbel, Edith Bigot-Corbel, Sylvie Hermouet, Sylvie Hermouet   +19 more
doaj   +1 more source

Serum protein fingerprinting by PEA immunoassay coupled with a pattern-recognition algorithms distinguishes MGUS and multiple myeloma [PDF]

, 2016
Serum protein fingerprints associated with MGUS and MM and their changes in MM after autologous stem cell transplantation (MM-ASCT, day 100) remain unexplored.
Fillerová, Regina, Gajdoš, Petr, Kriegová, Eva, Krömer, Pavel, Kudělka, Miloš, Minařík, Jiří, Papajík, Tomáš, Pika, Tomáš, Schneiderová, Petra, Ščudla, Vlastimil   +9 more
core   +1 more source

Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]

, 2012
Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone, Rajalingam, Krishnaraj, Dikic, Ivan   +2 more
core   +2 more sources

Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Bone Reports, 2021
Myeloma bone disease is a major complication in multiple myeloma affecting quality of life and survival. It is characterized by increased activity of osteoclasts, bone resorbing cells.
Konstantin Byrgazov, Thomas Lind, Annica J. Rasmusson, Claes Andersson, Ana Slipicevic, Fredrik Lehmann, Joachim Gullbo, Håkan Melhus, Rolf Larsson, Mårten Fryknäs   +9 more
doaj   +1 more source

JNK signalling in cancer: In need of new, smarter therapeutic targets [PDF]

, 2013
Copyright © 2013 The British Pharmacological Society. This is the accepted version of the following article: Bubici, C. and Papa, S. (2014), JNK signalling in cancer: in need of new, smarter therapeutic targets.
Adams, Ahmed, Anbalagan, Annunziata, Antonyak, Bain, Barbarulo, Barr, Behrens, Bennett, Bharti, Bogoyevitch, Bogoyevitch, Borsello, Bost, Carboni, Cazanave, Cellurale, Cellurale, Cellurale, Chang, Chang, Chauhan, Chen, Chen, Chen, Chen-Deutsch, Cho, Choi, Chromik, Cilloni, Cripe, Cui, Cui, Das, Davis, Deininger, Dérijard, Eferl, Estey, Farazi, Ferrandi, Finegan, Fuchs, Gaillard, Gao, Gao, Gilmore, Goenka, Graff, Gururajan, Hagiwara, He, Heo, Hess, Hideshima, Hideshima, Hideshima, Hirosumi, Ho, Huang, Hui, Hunot, Jaeschke, Jagtap, Jemal, Johnson, Kamenecka, Kaneto, Kaoud, Ke, Keats, Kersting, Kuan, Kuperwasser, Li, Llovet, Lloyd, LoGrasso, Luedde, Maclean, Maeda, Mamay, Manning, Manning, Min, Mucha, Murati, Nagata, Nateri, Ngoei, Ngoei, Nitta, Oleinik, Owens, Papa, Papa, Plantevin Krenitsky, Qiu, Raitano, Reinecke, Ricard, Rodrigues, Ronaldson, Roy, Sabapathy, Sakurai, Schramek, Seki, She, Siddiqui, Smeal, Srivastava, Stebbins, Su, Su, Szczepankiewicz, Takahashi, Tong, Tournier, Tsuiki, Waetzig, Wagner, Wang, Wang, Webster, Whitmarsh, Whitmarsh, Yamamoto, Yan, Yang, Yao, Yoon, Yoshida, Zhang, Zhang, Zhang, Zhang   +137 more
core   +2 more sources

The serum level alterations of Acute-phase proteins, serum alpha-1-acid glycoprotein, haptoglobin and alpha-2-Macroglobulin in the Patients with Stage I of Multiple Myeloma [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2020
Background & Aims:  Acute phase proteins are mainly synthesized by the liver and macrophages in inflammatory conditions as a result of various traumas and malignancies.
sonya mahabadi, mohamadhasan khadem ansari, Fatemeh Kheradmand, Youssef Rasmi   +3 more
doaj