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PHYSICOCHEMICAL CHARACTERIZATION OF MOUSE MYELOMA PROTEINS: DEMONSTRATION OF HETEROGENEITY FOR EACH MYELOMA GLOBULIN [PDF]
The Journal of Experimental Medicine, 1961 Physicochemical characterization of mouse myeloma proteins revealed the individuality of each myeloma protein. When the myeloma proteins are considered collectively a wide range of individual properties were represented, including electrophoretic mobilities varying from the gamma to alpha region, hexose contents from 1 to 4 per cent, and ...
John L. Fahey
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Myeloma protein kinetics following chemotherapy [PDF]
Blood, 1982 The effects of chemotherapy were evaluated in 43 multiple myeloma patients with high monoclonal globulin levels in both serum and urine. In responding patients, Bence Jones protein excretion declined more rapidly and markedly than the serum myeloma protein.
P McLaughlin, Raymond Alexanian
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Cell-Bound Myeloma Proteins on the Surface of Myeloma Cells: Potential Targets for the Immune System [PDF]
Proceedings of the National Academy of Sciences, 1972 Rosette formation with 2,4,6-trinitrophenylated (Tnp)-sheep erythrocytes was used to demonstrate cell-bound myeloma proteins on cells from each of the eleven mouse plasmacytomas tested. Tnp-erythrocytes were bound directly by cells from two tumors (MOPC-315 and MOPC-460) that formed myeloma proteins with antihapten combining sites; rosette formation ...
Kristian Hannestad +2 more
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Myeloma Proteins, Bence Jones Proteins and Normal Immunoglobulins in Multiple Myeloma [PDF]
Blood, 1967 Abstract The relationship between the anomalous and normal immunoglobulins was studied through measurement of myeloma protein (MP), Bence Jones protein (BJP), and the normal γG, γA, γM and γD-globulin levels in a large group of patients with multiple myeloma. These determinations were made prior to and after initiation of three different
Vincent Caggiano +3 more
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Protein tyrosine phosphatases in multiple myeloma
Cancer Letters, 2021 Many cell signaling pathways are activated or deactivated by protein tyrosine phosphorylation and dephosphorylation, catalyzed by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), respectively. Even though PTPs are as important as PTKs in this process, their role has been neglected for a long time.
Pegah Abdollahi +2 more
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Indonesian Journal of Pharmacy, 2009 Carica papaya L. leaves are potential for cancer treatment, this is due to the presence of Ribosome-inactivating proteins (RIPs), which demonstrated a cytotoxic effect on cancer cell lines.
Sismindari +3 more
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mAbs, 2020 Antibodies that target a clinically relevant group of receptors within the tumor necrosis factor receptor superfamily (TNFRSF), including CD40 and CD95 (Fas/Apo-1), also require binding to Fc gamma receptors (FcγRs) to elicit a strong agonistic activity.
Johannes Nelke +4 more
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Journal of Veterinary Internal Medicine, 2021 Background Current recommendations for monitoring disease progression and response to treatment in humans with multiple myeloma include evaluation of serum paraprotein (M‐protein) concentration. Densitometry, species‐specific radial immunodiffusion (RID)
A Russell Moore +4 more
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Biclonal gammopathy – A single-center experience
Iraqi Journal of Hematology, 2023 BACKGROUND: Biclonal gammopathies are characterized by the production of two distinct monoclonal proteins. It is defined as the presence of two distinct M bands in serum protein electrophoresis.
Geetha Narayanan +4 more
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Haematologica, 2011 Background Isothiocyanates, a family of phytochemicals found in cruciferous vegetables, have cytotoxic effects against several types of tumor cells. Multiple myeloma is a fatal disease characterized by clonal proliferation of plasma cells in the bone ...
Jana Jakubikova +17 more
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