Results 271 to 280 of about 87,373 (338)

COMMD3 Regulates Copper Metabolism via the ATOX1-ATP7A-LOX Axis to Promote Multiple Myeloma Progression. [PDF]

Biomedicines
Wang Y, Zhang B, Fan F, Zhao F, Xu J, Zheng Y, Sun C, Hu Y.   +7 more
europepmc   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

An Update of the Appropriate Sequencing for Salvage Therapies in Multiple Myeloma. [PDF]

Mediterr J Hematol Infect Dis
Barilà G, Rezzonico F, Pavan L, Corso A, Zambello R.   +4 more
europepmc   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

High-Risk Genetic Multiple Myeloma: From Molecular Classification to Innovative Treatment with Monoclonal Antibodies and T-Cell Redirecting Therapies. [PDF]

Cells
De Novellis D, Scala P, Giudice V, Selleri C.   +3 more
europepmc   +1 more source

KHOZ (KEL41): A novel low‐prevalence antigen in the Kell blood group system antithetical to KHIZ (KEL40)

Transfusion, EarlyView.
Genghis H. Lopez, Kerman N. Buhariwala, Jennifer A. Condon, Glenda M. Millard, Ina Messig, Tanya Powley, Alexandre Raneri, Robert L. Flower, Yew‐Wah Liew, Slim Azouzi, Thierry Peyrard, Catherine A. Hyland   +11 more
wiley   +1 more source

Dual Targeting of Pim and PI3 Kinases in Mature T‐Cell Lymphoma

European Journal of Haematology, Volume 115, Issue 1, Page 82-95, July 2025.
ABSTRACT Provirus Integration site for Moloney leukemia virus (Pim) family members are well‐known oncogenes, with an expression that is restricted to few cell types including hematopoietic cells in adult organisms, making it a promising target for lymphoma treatment.
M. Lohrberg, M. Heber, L. Ries, K. Markus, N. Ksionsko, N. Schmidt, G. Nothnick, L. Thielking, M. O'Neill, S. Martínéz‐González, C. Blanco‐Aparicio, J. Pastor, D. Cunningham, R. Koch   +13 more
wiley   +1 more source

Analysis of Ubiquitin-Conjugating Enzyme E2T (UBE2T) Protein Levels in the Bone Marrow Biopsy Specimens of Patients With Multiple Myeloma. [PDF]

Cureus
Wang F, Yu N, Xia R.
europepmc   +1 more source

Generation of Conformation-Specific Monoclonal Antibodies for Integral Membrane Proteins. [PDF]

Curr Protoc
Sheldon N, Dhandapani G, Kim J, Spangler CJ, Fang C, Park J, Rao P, Gouaux E.   +7 more
europepmc   +1 more source

Is Salvage Autologous Stem Cell Transplantation Still a Viable Treatment Option in Relapsed Myeloma Patients? [PDF]

Medicina (Kaunas)
Čemažar L, Škerget M, Skopec B.
europepmc   +1 more source