Results 271 to 280 of about 76,403 (315)
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Globulin and myeloma: The structural characterization of γ-globulin and myeloma protein
Archives of Biochemistry and Biophysics, 1962Abstract α-, β-, M - and γ-Type myeloma proteins were obtained by electrophoretic separation, and each protein was characterized by its amino acid composition, molecular weight, optical rotation, and infrared spectrum. The peculiar optical rotatory behavior of α-, β-, and γ-myeloma protein indicated that these proteins are to be classified as γ ...
Hironao Momoi, Kazutomo Imahori
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Contribution of Inhibition of Protein Catabolism in Myeloma
The Cancer Journal, 2019AbstractMultiple myeloma (MM) is a cancer of plasma cells, characterized by abundant synthesis of monoclonal immunoglobulins and/or free light chains. Although MM remains incurable, median overall survival has considerably improved over the past 2 decades largely due to the introduction of novel agents, including proteasome inhibitors (PIs) and ...
Kenneth C. Anderson, Giada Bianchi
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An unusual tryptic cleavage of a myeloma protein
Immunochemistry, 1978Abstract Digestion of IgG† Zie with trypsin produced two fragments which differed from the characteristic tFab and tFc normally obtained from tryptic cleavage of IgG. These two unique fragments, designated t 1 and T s were isolated from a tryptic digest of IgG Zie by gel filtration in dissociating solvents.
G. E. Connell, C.A. Laschinger
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A Calcium Binding IgG Myeloma Protein
Scandinavian Journal of Haematology, 1980A calcium binding IgG was isolated and purified by column chromatography from serum of a myeloma patient with asymptomatic hypercalcaemia. The myeloma IgG, characterized as an IgG kappa, revealed a normal sized heavy chain (56000 dalton), and a light chain of 31000 dalton.
Gad Spira +3 more
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ANTIGEN‐BINDING MYELOMA PROTEINS IN MICE
Annals of the New York Academy of Sciences, 1971Publisher Summary The immunoglobulins are a large family of structurally related proteins secreted by plasma cells. Plasma cells are normally differentiated so that each cell is usually restricted to making immunoglobulin with only a single VL and VH region. This chapter reviews to the immunochemical propeities of the antigen-binding myeloma proteins
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Proteins in multiple myeloma. VI. Cryoglobulins
Archives of Biochemistry and Biophysics, 1956Abstract Eight cryoglobulins (abnormal human plasma globulins that have diminished solubility in the cold) have been investigated by means of the analytical ultracentrifuge, electrophoresis, N-terminal amino acid analysis, and serological classification.
Aiko Miyake, Frank W. Putnam
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Biologic properties of E myeloma proteins
The American Journal of Medicine, 1971Abstract E myeloma protein PS (PS protein) from the serum of the second known patient (P.S.) with IgE myeloma was purified by DEAE-cellulose column chromatography and Sephadex ® G-200 gel filtration. The physicochemical properties of this protein were identical with those of E myeloma protein ND (ND protein) from the first patient with IgE myeloma ...
William D. Terry +5 more
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Some properties of β2a-myeloma proteins
Clinica Chimica Acta, 1964Abstract 1. 1. Seventeenβ2A-type myeloma sera and 40γ-type myeloma sera were examined paper electrophoretically, immunologically, and by ultracentrifugation. 2. 2. On paper electrophoresis,γ-type myeloma proteins are predominantly located in theγ1-γ2-globulin positions, the β2A-type myeloma proteins preferentially at the β2-γ1-globulin ...
J.P. Seeuwen +3 more
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Specificity of T and B lymphocytes for myeloma protein 315
European Journal of Immunology, 1977AbstractThe antibody response of BALB/c mice directed against the idiotype of the BALB/c myeloma protein MOPC 315 (M315) is T cell‐dependent. The specificity of helper T cells for M31 5 was investigated. Helper cells were primed with M31 5, M315 affinity‐labeled with Nα‐bromoacetyl‐Nε‐2,4‐dinitrophenyl‐L‐lysine, M315 L‐chain and H‐chain the M315 Fv ...
Jorgensen, T, Hannestad, K
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Steroid-carrier proteins in patients with multiple myeloma
Journal of Steroid Biochemistry, 1986Patients with multiple myeloma have transcortin levels lower than normal. This is due in essence to a subgroup of patients producing IGG heavy chains with lambda light chains. Patients producing IGG with predominantly kappa light chains have almost normal transcortin levels.
de Moor, P. +3 more
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