Results 21 to 30 of about 5,867,860 (378)

Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]

, 2017
Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana, Cippitelli, Marco, Fionda, Cinzia, Santoni, Angela, Soriani, Alessandra, Zingoni, Alessandra   +5 more
core   +1 more source

PROTEINS IN MULTIPLE MYELOMA

Journal of Biological Chemistry, 1956
Frank W. Putnam, Franz Meyer, Aiko Miyake   +2 more
openalex   +2 more sources

Protein Targeting Chimeric Molecules Specific for Bromodomain and Extra-terminal Motif Family Proteins are Active Against Pre-Clinical Models of Multiple Myeloma

Leukemia, 2018
Bromodomain and extraterminal (BET) domain containing protein (BRD)-4 modulates the expression of oncogenes such as c-myc, and is a promising therapeutic target in diverse cancer types.
Xiaohui Zhang, Xiaohui Zhang, Hans C. Lee, F. Shirazi, V. Baladandayuthapani, Heather C. Lin, I. Kuiatse, Hua Wang, R. J. Jones, Z. Berková, Ram K. Singh, Jing Lu, Y. Qian, Kanak Raina, K. Coleman, C. Crews, Bingzong Li, H. Wang, Y. Hailemichael, S. Thomas, Zhiqiang Wang, R. Davis, R. Orlowski   +22 more
semanticscholar   +1 more source

RUNX proteins desensitize multiple myeloma to lenalidomide via protecting IKZFs from degradation

bioRxiv, 2018
Ikaros family zinc finger protein 1 and 3 (IKZF1 and IKZF3) are transcription factors that promote multiple myeloma (MM) proliferation. The immunomodulatory imide drug (IMiD) lenalidomide promotes myeloma cell death via Cereblon (CRBN)-dependent ...
N. Zhou, A. G. Uzquiza, Xiang-yu Zheng, D. Vogl, A. Garfall, L. Bernabei, Anita Saraf, L. Florens, M. Washburn, A. Illendula, J. Bushweller, L. Busino   +11 more
semanticscholar   +1 more source

Advances in the design and development of oncolytic measles viruses. [PDF]

, 2015
A successful oncolytic virus is one that selectively propagates and destroys cancerous tissue without causing excessive damage to the normal surrounding tissue. Oncolytic measles virus (MV) is one such virus that exhibits this characteristic and thus has
Hutzen, Brian, Raffel, Corey, Studebaker, Adam W   +2 more
core   +1 more source

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma

Journal of Cell Biology, 1975
Fractionation of MOPC 41 DL-1 tumors revealed that the mRNA for the light chain of immunoglobulin is localized exclusively in membrane- bound ribosomes.
G. Blobel, B. Dobberstein
semanticscholar   +1 more source

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma [PDF]

, 2012
Copyright @ 2013 Macmillan Publishers Limited. This is the author's accepted manuscript. The final published article is available from the link below.Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM).
A Barbarulo, A Chaidos, A Karadimitris, A Rahemtulla, AJ Bardwell, C Bubici, C-H Yoon, CG Pham, CR Geest, D Chauhan, D O Haskard, E Spanoudakis, EF Wagner, F Bost, F Zazzeroni, F Zhan, F Zhan, G Franzoso, H Ke, H Ke, J Cui, J Cui, J Ford, J Liu, K Kim, K Naresh, K Pruitt, K Sabapathy, KC Anderson, KN Naresh, L Aravind, L Hui, LC Platanias, M Anbalagan, M Blonska, M Gururajan, M Hallek, M Raman, M Wiznerowicz, MA Bogoyevitch, MA Bogoyevitch, MS Raab, N Chen, NJ Kennedy, NN Gangopadhyay, RT Nitta, S Goenka, S Goenka, S Papa, S Papa, SH Cho, SH Cho, SU Ahmed, SV Rajkumar, T Hideshima, T Hideshima, T Hideshima, T Kajiguchi, T Yanagawa, TE Witzig, V Brune, V Iansante, V Schreiber, YM Yang   +63 more
core   +2 more sources

Biclonal myeloma in renal failure

Central European Journal of Immunology, 2020
Multiple myeloma is a clonal proliferation of the plasma cell line that accounts for approximately 10% of all hematological malignancies. It is characterized by abnormal growth of plasma cells producing monoclonal immunoglobulin or light chain ...
Milena K. Nikolova-Vlahova, Miroslava Kamburova, Julieta Hristova, Dimitrios Vasileiou, Boris Bogov, Rumiana Krasteva, Evgeni Hadjiev, Gergana Tsvetkova, Cvetelina Vasileva, Nikolai Houbanov   +9 more
doaj   +1 more source

Enhancement of platelet response to immune complexes and IgG aggregates by lipid A-rich bacterial lipopolysaccharides. [PDF]

, 1978
The effect of the common lipid moiety of bacterial LPS on secretion from washed human platelets has been studied. The lipid A-rich LPS of S. minnesota R595 and a lipid A preparation both potentiated platelet serotonin secretion in response to IgG ...
Ginsberg, MH, Henson, PM
core   +1 more source

Half-Life Extended Nanobody-Based CD38-Specific Bispecific Killercell Engagers Induce Killing of Multiple Myeloma Cells

Frontiers in Immunology, 2022
CD38 is a target for immunotherapy of multiple myeloma. Llama-derived CD38-specific nanobodies allow easy reformatting into mono-, bi- and multispecific proteins.
Julia Hambach, Julia Hambach, William Fumey, William Fumey, Tobias Stähler, Anna Josephine Gebhardt, Anna Josephine Gebhardt, Gerhard Adam, Katja Weisel, Friedrich Koch-Nolte, Peter Bannas   +10 more
doaj   +1 more source