Results 21 to 30 of about 76,403 (315)

The concentration and type of monoclonal protein and their impact on clinical severity in patients with symptomatic myeloma

Advanced Medical Journal, 2022
Background and objectives: Multiple Myeloma is a clonal plasma cell proliferation in the bone marrow that produces abnormal monoclonal proteins in serum and /or urine that leads to end-organ damage. We aimed to evaluate concentration, type of monoclonal
Ahmed Khudair Yassin, Najmaddin Salih Husen Khsohnaw, Sana Dlawar Jalal, Akram Mahmood Mohammed, Kawa Mohamedamin Hasan , Dana Ahmed Abdulla, Ameer Badi, Banaz Mubarak Safar, Basil Kadhim Abdulla, Rawand Polus Shamoon, Diveen Jalal Hussein, Nawsherwan Sadiq Mohammed, Kanar Jalal Karim, Abid Mohiaddin Hassen, Hisham Arf Getta, Rezhin Nawzad Rajab, Friad Hiwaizi Hiwaizi, Truska Awat Amin, Zeki Ali Mohamed, Ali Ibrahim Mohammed, Hameed Saeed, Parween Ismael, Alaa Alwan   +22 more
doaj   +1 more source

Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model

Biomolecules, 2019
Here, we determined the anti-neoplastic actions of formononetin (FT) against multiple myeloma (MM) and elucidated its possible mode of action. It was observed that FT enhanced the apoptosis caused by bortezomib (Bor) and mitigated proliferation in MM ...
Chulwon Kim, Jong Hyun Lee, Jeong-Hyeon Ko, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H.M. Shair, Gautam Sethi, Kwang Seok Ahn   +7 more
doaj   +1 more source

Inhibition of fatty acid metabolism reduces human myeloma cells proliferation. [PDF]

PLoS ONE, 2012
Multiple myeloma is a haematological malignancy characterized by the clonal proliferation of plasma cells. It has been proposed that targeting cancer cell metabolism would provide a new selective anticancer therapeutic strategy.
José Manuel Tirado-Vélez, Insaf Joumady, Ana Sáez-Benito, Irene Cózar-Castellano, Germán Perdomo   +4 more
doaj   +1 more source

IS IT POSSIBLE TO PREDICT TUMOR PROGRESSION THROUGH GENOMIC CHARACTERIZATION OF MONOCLONAL GAMMOPATHY AND SMOLDERING MULTIPLE MYELOMA?

Mediterranean Journal of Hematology and Infectious Diseases
The study of monoclonal serum proteins has led to the generation of two major theories: one proposing that individuals who had monoclonal proteins without any symptoms or evidence of end-organ damage have a benign condition; the other one suggesting ...
Ugo Testa, Giuseppe Leone, Elvira Pelosi, Germana Castelli, Valerio De Stefano   +4 more
doaj   +1 more source

Hepatocyte growth factor promotes migration of human myeloma cells

Haematologica, 2008
Multiple myeloma is characterized by the accumulation and dissemination of malignant plasma cells in the bone marrow. Cell migration is thought to be important for these events.
Randi Utne Holt, Unn-Merete Fagerli, Vadim Baykov, Torstein Baade Rø, Håkon Hov, Anders Waage, Anders Sundan, Magne Børset   +7 more
doaj   +1 more source

"Myeloma Protein" in a Patient with Monocytic Leukemia [PDF]

Blood, 1969
Abstract A 74 year old man with monocytic leukemia was found to have serum and urinary protein findings typical of myelomatosis. Lysozyme excretion in the urine was in the range characteristic of monocytic leukemia. There were no x-ray findings indicative of myeloma.
Lawrence Berman, Ananda S. Prasad, M. Dave Poulik   +2 more
openaire   +3 more sources

Elotuzumab as a novel anti-myeloma immunotherapy

Human Vaccines & Immunotherapeutics, 2017
Treatment of multiple myeloma has undergone significant change in the last decade with the introduction of new immunomodulatory agents, proteasome inhibitors, and immunotherapeutic approaches.
Sabarinath Venniyil Radhakrishnan, Neelam Bhardwaj, Mary Steinbach, Janet Weidner, Tim Luetkens, Djordje Atanackovic   +5 more
doaj   +1 more source

Transcriptome analysis reveals molecular profiles associated with evolving steps of monoclonal gammopathies

Haematologica, 2014
A multistep model has been proposed of disease progression starting in monoclonal gammopathy of undetermined significance continuing through multiple myeloma, sometimes with an intermediate entity called smoldering myeloma, and ending in extramedullary ...
Lucía López-Corral, Luis Antonio Corchete, María Eugenia Sarasquete, María Victoria Mateos, Ramón García-Sanz, Encarna Fermiñán, Juan-José Lahuerta, Joan Bladé, Albert Oriol, Ana Isabel Teruel, María Luz Martino, José Hernández, Jesús María Hernández-Rivas, Francisco Javier Burguillo, Jesús F. San Miguel, Norma C. Gutiérrez   +15 more
doaj   +1 more source

Will Mass Spectrometry Replace Current Techniques for Both Routine Monitoring and MRD Detection in Multiple Myeloma?

Hemato, 2021
In recent years, mass spectrometry has been increasingly used for the detection of monoclonal proteins in serum. Mass spectrometry is more analytically sensitive than serum protein electrophoresis and immunofixation, can help distinguish therapeutic ...
Katie L. Thoren
doaj   +1 more source

IMMUNOLOGICAL RELATIONSHIPS AMONG THE MYELOMA PROTEINS [PDF]

The Journal of Experimental Medicine, 1955
An immunological study of 21 myeloma sera was carried out to determine their relationship to components of normal γ-globulin and to each other. Ten proteins were separated for detailed characterization. Every one of the myeloma proteins studied was immunologically different, indicating individual specificity.
S. M. Ward, Robert J. Slater, Henry G. Kunkel   +2 more
openaire   +3 more sources