Results 21 to 30 of about 87,373 (338)

Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma

Haematologica, 2011
Background Isothiocyanates, a family of phytochemicals found in cruciferous vegetables, have cytotoxic effects against several types of tumor cells. Multiple myeloma is a fatal disease characterized by clonal proliferation of plasma cells in the bone ...
Jana Jakubikova, David Cervi, Melissa Ooi, Kihyun Kim, Sabikun Nahar, Steffen Klippel, Dana Cholujova, Merav Leiba, John F. Daley, Jake Delmore, Joseph Negri, Simona Blotta, Douglas W. McMillin, Teru Hideshima, Paul G. Richardson, Jan Sedlak, Kenneth C. Anderson, Constantine S. Mitsiades   +17 more
doaj   +1 more source

CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonism

mAbs, 2020
Antibodies that target a clinically relevant group of receptors within the tumor necrosis factor receptor superfamily (TNFRSF), including CD40 and CD95 (Fas/Apo-1), also require binding to Fc gamma receptors (FcγRs) to elicit a strong agonistic activity.
Johannes Nelke, Juliane Medler, Daniela Weisenberger, Andreas Beilhack, Harald Wajant   +4 more
doaj   +1 more source

The concentration and type of monoclonal protein and their impact on clinical severity in patients with symptomatic myeloma

Advanced Medical Journal, 2022
Background and objectives: Multiple Myeloma is a clonal plasma cell proliferation in the bone marrow that produces abnormal monoclonal proteins in serum and /or urine that leads to end-organ damage. We aimed to evaluate concentration, type of monoclonal
Ahmed Khudair Yassin, Najmaddin Salih Husen Khsohnaw, Sana Dlawar Jalal, Akram Mahmood Mohammed, Kawa Mohamedamin Hasan , Dana Ahmed Abdulla, Ameer Badi, Banaz Mubarak Safar, Basil Kadhim Abdulla, Rawand Polus Shamoon, Diveen Jalal Hussein, Nawsherwan Sadiq Mohammed, Kanar Jalal Karim, Abid Mohiaddin Hassen, Hisham Arf Getta, Rezhin Nawzad Rajab, Friad Hiwaizi Hiwaizi, Truska Awat Amin, Zeki Ali Mohamed, Ali Ibrahim Mohammed, Hameed Saeed, Parween Ismael, Alaa Alwan   +22 more
doaj   +1 more source

Multi-scale Regional Attention Deeplab3+: Multiple Myeloma Plasma Cells Segmentation in Microscopic Images [PDF]

arXiv, 2021
Multiple myeloma cancer is a type of blood cancer that happens when the growth of abnormal plasma cells becomes out of control in the bone marrow. There are various ways to diagnose multiple myeloma in bone marrow such as complete blood count test (CBC) or counting myeloma plasma cell in aspirate slide images using manual visualization or through image
arxiv  

Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model

Biomolecules, 2019
Here, we determined the anti-neoplastic actions of formononetin (FT) against multiple myeloma (MM) and elucidated its possible mode of action. It was observed that FT enhanced the apoptosis caused by bortezomib (Bor) and mitigated proliferation in MM ...
Chulwon Kim, Jong Hyun Lee, Jeong-Hyeon Ko, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H.M. Shair, Gautam Sethi, Kwang Seok Ahn   +7 more
doaj   +1 more source

Inhibition of fatty acid metabolism reduces human myeloma cells proliferation. [PDF]

PLoS ONE, 2012
Multiple myeloma is a haematological malignancy characterized by the clonal proliferation of plasma cells. It has been proposed that targeting cancer cell metabolism would provide a new selective anticancer therapeutic strategy.
José Manuel Tirado-Vélez, Insaf Joumady, Ana Sáez-Benito, Irene Cózar-Castellano, Germán Perdomo   +4 more
doaj   +1 more source

Matrix metalloproteinases and tissue inhibitors in multiple myeloma: promote or inhibit?

Frontiers in Oncology, 2023
Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) play a vital role in the pathogenesis of multiple myeloma (MM), especially for tumor invasion and osteolytic osteopathy.
Yan-Ying Li, Yan-Ying Li, Liu-Yun Zhang, Liu-Yun Zhang, Yun-Hui Xiang, Yun-Hui Xiang, Dan Li, Juan Zhang   +7 more
doaj   +1 more source

IS IT POSSIBLE TO PREDICT TUMOR PROGRESSION THROUGH GENOMIC CHARACTERIZATION OF MONOCLONAL GAMMOPATHY AND SMOLDERING MULTIPLE MYELOMA?

Mediterranean Journal of Hematology and Infectious Diseases
The study of monoclonal serum proteins has led to the generation of two major theories: one proposing that individuals who had monoclonal proteins without any symptoms or evidence of end-organ damage have a benign condition; the other one suggesting ...
Ugo Testa, Giuseppe Leone, Elvira Pelosi, Germana Castelli, Valerio De Stefano   +4 more
doaj   +1 more source

Hepatocyte growth factor promotes migration of human myeloma cells

Haematologica, 2008
Multiple myeloma is characterized by the accumulation and dissemination of malignant plasma cells in the bone marrow. Cell migration is thought to be important for these events.
Randi Utne Holt, Unn-Merete Fagerli, Vadim Baykov, Torstein Baade Rø, Håkon Hov, Anders Waage, Anders Sundan, Magne Børset   +7 more
doaj   +1 more source

Modeling the Effects of Multiple Myeloma on Kidney Function [PDF]

, 2016
Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis. We develop a mathematical model which captures the qualitative behavior of the cell and protein populations involved.
arxiv   +1 more source