Results 31 to 40 of about 76,403 (315)
Type I-conventional dendritic cells support the progression of multiple myeloma in the bone marrow
Frontiers in ImmunologyPurposeType I conventional dendritic cells (cDC1s) play a key role in priming anti-tumor cytotoxic T cells and inducing immune tolerance for self-antigens and tumor antigens. However, it remains unclear whether cDC1 has a protective or pathogenic role in
Sayaka Suzuki +10 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: The purpose of our experiments was to investigate the targeting relationship of linc00515, miR-140-5p and ATG14 and to explore the roles of linc00515, miR-140-5p and ATG14 in autophagy and chemoresistance of melphalan-resistant multiple ...
Daifeng Lu +4 more
doaj +1 more source
Heat shock proteins in multiple myeloma [PDF]
Oncotarget, 2014 Heat shock proteins are molecular chaperones with a central role in protein folding and cellular protein homeostasis. They also play major roles in the development of cancer and in recent years have emerged as promising therapeutic targets. In this review, we discuss the known molecular mechanisms of various heat shock protein families and their ...
Jacqueline H. L. Fok +2 more
openaire +3 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Matrix metalloproteinases and tissue inhibitors in multiple myeloma: promote or inhibit?
Frontiers in Oncology, 2023 Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) play a vital role in the pathogenesis of multiple myeloma (MM), especially for tumor invasion and osteolytic osteopathy.
Yan-Ying Li +7 more
doaj +1 more source
THE CARBOHYDRATE OF γ-GLOBULIN AND MYELOMA PROTEINS [PDF]
The Journal of Experimental Medicine, 1956 Various preparations of γ-globulin homogeneous in the ultracentrifuge showed a similar content of hexose, hexosamine, fucose, and sialic acid. Subfractionation of Fr. II γ-globulin by zone electrophoresis revealed multiple components of different mean mobilities but containing similar amounts of carbohydrate.
Henry G. Kunkel +1 more
openaire +3 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
N-glycosylation of serum proteins for the assessment of patients with IgD multiple myeloma
BMC Cancer, 2017 Background Because glycosylation is one of the most common post-translational modifications of proteins and because changes in glycosylation have been shown to have a significant correlation with the development of many cancer types, we investigated the ...
Jie Chen +9 more
doaj +1 more source
Protein Profiling in Myeloma In Vivo; Effects of Bortezomib in a Mouse Model of Myeloma.
Blood, 2007 Abstract The proteasome inhibitor bortezomib (VELCADE®) represents an important advance in the treatment of multiple myeloma. Despite its very significant beneficial effects, its precise mechanism of action remains unclear. There is currently evidence to suggest that bortezomib has the potential to directly affect both myeloma cells and ...
Edwards, C +8 more
openaire +3 more sources
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source