Results 31 to 40 of about 5,867,860 (378)
Journal of Clinical Oncology, 2018 Purpose Therapies with novel mechanisms of action are needed for multiple myeloma (MM). T cells can be genetically modified to express chimeric antigen receptors (CARs), which are artificial proteins that target T cells to antigens.
Jennifer N. Brudno +20 more
semanticscholar +1 more source
Structure-function relations in phosphorylcholine-binding mouse myeloma proteins [PDF]
, 1977 The binding site interactions between the phosphorylcholine (phosphocholine)-binding mouse myeloma proteins TEPC 15, W3207, McPC 603, MOPC 167, and MOPC 511 and the isotopically substituted hapten phosphoryl-[methyl-13C]choline have been investigated ...
Goetze, Andrew M., Richards, John H.
core +2 more sources
Disruption of HOX activity leads to cell death that can be enhanced by the interference of iron uptake in malignant B cells. [PDF]
, 2010 The HOX genes encode a family of transcription factors that are dysregulated in several malignancies and have been implicated in oncogenesis and cancer cell survival.
Daniels, TR +5 more
core +1 more source
Multiple myeloma (pathogenesis, clinical features, diagnosis, differential diagnosis). Part I
Клиническая онкогематология, 2013 Multiple myeloma (MM) is a malignancy characterized by bone marrow infiltration with plasma cell and extensive skeletal bone destruction resulting in bone pain and fractures.
S. S. Bessmeltsev
doaj +1 more source
Journal of Experimental Medicine, 1962 Antisera to normal 7S γ-globulin and to Bence Jones proteins permit the grouping of myeloma proteins (gamma and beta 2A types), Bence Jones proteins, and the Waldenström type macroglobulins into two fundamental antigenic groups.
M. Mannik, H. Kunkel
semanticscholar +1 more source
Protein tyrosine phosphatases in multiple myeloma
Cancer Letters, 2021 Many cell signaling pathways are activated or deactivated by protein tyrosine phosphorylation and dephosphorylation, catalyzed by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), respectively. Even though PTPs are as important as PTKs in this process, their role has been neglected for a long time.
Pegah Abdollahi +2 more
openaire +3 more sources
Surface molecule CD229 as a novel target for the diagnosis and treatment of multiple myeloma
Haematologica, 2011 Background To date, multiple myeloma remains an incurable malignancy due to the persistence of minimal residual disease in the bone marrow. In this setting, monoclonal antibodies against myeloma-specific cell surface antigens represent a promising ...
Djordje Atanackovic +14 more
doaj +1 more source
Biclonal gammopathy – A single-center experience
Iraqi Journal of Hematology, 2023 BACKGROUND: Biclonal gammopathies are characterized by the production of two distinct monoclonal proteins. It is defined as the presence of two distinct M bands in serum protein electrophoresis.
Geetha Narayanan +4 more
doaj +1 more source
H CHAIN SUBGROUPS OF MYELOMA PROTEINS AND NORMAL 7S γ-GLOBULIN
Journal of Experimental Medicine, 1964 Through the use of a variety of antisera to isolated myeloma proteins, four subgroups of 7S γ-globulin type proteins were readily distinguished. The first, the Vi subgroup, consisted of ten of 64 myeloma proteins studied.
H. Grey, H. Kunkel
semanticscholar +1 more source
Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease [PDF]
, 2020 The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
Li, Jing, Sherman, David J.
core