Results 31 to 40 of about 87,373 (338)
"Myeloma Protein" in a Patient with Monocytic Leukemia [PDF]
Blood, 1969 Abstract A 74 year old man with monocytic leukemia was found to have serum and urinary protein findings typical of myelomatosis. Lysozyme excretion in the urine was in the range characteristic of monocytic leukemia. There were no x-ray findings indicative of myeloma.
Lawrence Berman +2 more
openaire +3 more sources
Elotuzumab as a novel anti-myeloma immunotherapy
Human Vaccines & Immunotherapeutics, 2017 Treatment of multiple myeloma has undergone significant change in the last decade with the introduction of new immunomodulatory agents, proteasome inhibitors, and immunotherapeutic approaches.
Sabarinath Venniyil Radhakrishnan +5 more
doaj +1 more source
Haematologica, 2014 A multistep model has been proposed of disease progression starting in monoclonal gammopathy of undetermined significance continuing through multiple myeloma, sometimes with an intermediate entity called smoldering myeloma, and ending in extramedullary ...
Lucía López-Corral +15 more
doaj +1 more source
Multiple Myeloma Cancer Cell Instance Segmentation [PDF]
arXiv, 2021 Images remain the largest data source in the field of healthcare. But at the same time, they are the most difficult to analyze. More than often, these images are analyzed by human experts such as pathologists and physicians. But due to considerable variation in pathology and the potential fatigue of human experts, an automated solution is much needed ...
arxiv
Determining Optimal Combination Regimens for Patients with Multiple Myeloma [PDF]
arXiv, 2022 While many novel therapies have been approved in recent years for treating patients with multiple myeloma, there is still no established curative regimen, especially for patients with high risk disease. In this work, we use a mathematical modeling approach to determine combination therapy regimens that maximize healthy lifespan for patients with ...
arxiv
Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
Type I-conventional dendritic cells support the progression of multiple myeloma in the bone marrow
Frontiers in ImmunologyPurposeType I conventional dendritic cells (cDC1s) play a key role in priming anti-tumor cytotoxic T cells and inducing immune tolerance for self-antigens and tumor antigens. However, it remains unclear whether cDC1 has a protective or pathogenic role in
Sayaka Suzuki +10 more
doaj +1 more source
Heat shock proteins in multiple myeloma [PDF]
Oncotarget, 2014 Heat shock proteins are molecular chaperones with a central role in protein folding and cellular protein homeostasis. They also play major roles in the development of cancer and in recent years have emerged as promising therapeutic targets. In this review, we discuss the known molecular mechanisms of various heat shock protein families and their ...
Jacqueline H. L. Fok +2 more
openaire +3 more sources
N-glycosylation of serum proteins for the assessment of patients with IgD multiple myeloma
BMC Cancer, 2017 Background Because glycosylation is one of the most common post-translational modifications of proteins and because changes in glycosylation have been shown to have a significant correlation with the development of many cancer types, we investigated the ...
Jie Chen +9 more
doaj +1 more source
Biotechnology & Biotechnological Equipment, 2021 Multiple myeloma (MM) is the most common bone marrow malignancy which is defined with bone marrow infiltration of more than 10% of terminally differentiated plasma cells sive myeloma cells.
Jurijs Nazarovs +5 more
doaj +1 more source