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Platelet Function, Role in Thrombosis, Inflammation, and Consequences in Chronic Myeloproliferative Disorders [PDF]
Platelets are conventionally defined as playing a vital role in homeostasis and thrombosis. This role has over the years transformed as knowledge regarding platelets has expanded to include inflammation, cancer progression, and metastasis.
Lisa Repsold, Anna Margaretha Joubert
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A review of current knowledge of myeloproliferative disorders in the horse [PDF]
Myeloid disorders are conditions being characterized by abnormal proliferation and development of myeloid lineage including granulocytes (neutrophils, eosinophils and basophils), monocytes, erythroids, and megakaryocytes precursor cells. Myeloid leukemia,
Katy Satué +2 more
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Hereditary myeloproliferative disorders
Hereditary forms of myeloproliferative disorders (MPD) can be divided into two broad categories. First, inherited syndromes that affect a single lineage with Mendelian inheritance, high penetrance and polyclonal hematopoiesis, and second, inherited predisposition to true MPD, characterized by ...
Radek C. Skoda
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JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders [PDF]
JAK inhibitors have been developed following the discovery of the JAK2V617F in 2005 as the driver mutation of the majority of non- BCR-ABL1 myeloproliferative neoplasms (MPNs).
William Vainchenker +5 more
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Background: It is still difficult to give a final diagnosis in chronic myeloproliferative disorders (CMPDs) because of the overlap of the common pathological and clinical features of these disorders like bone marrow fibrosis which is considered important
Ali Khalil I. Al-Khafaji +2 more
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Eosinophilic Myeloproliferative Disorders [PDF]
AbstractDespite recent attempts to define and classify patients with marked eosinophilia and features consistent with myeloproliferative disease, areas of controversy remain. These are particularly apparent in situations in which multiple lineages are involved in a clonal process and clinical manifestations are overlapping. Although the introduction of
A. Klion
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Chorea and Cognitive Impairment in JAK2V617F-Positive Myeloproliferative Disorders: A Case Report and Literature Review [PDF]
Chorea is a hyperkinetic movement disorder, accompanied by dystonia, myoclonus, tics, stereotypies, and tremors. It is characterized by excessive, purposeless movements that are distressing, irregularly timed, and randomly distributed.
Ioana Butnariu +7 more
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Pulmonary hypertension in patients with chronic myeloproliferative disorders. [PDF]
Pulmonary hypertension (PH) is a major complication of several haematological disorders. Chronic myeloproliferative diseases (CMPDs) associated with pulmonary hypertension have been included in group five of the clinical classification for pulmonary ...
Adir Y, Elia D, Harari S.
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Forty-three operative procedures were performed on a population of 250 patients with myeloproliferative disorders, including polycythemia vera, myeloid metaplasia (MM) and chronic myelogenous leukemia (CML). The overall operative mortality was approximately 7% and the incidence of excessive bleeding which could be related to coagulopathy was 5%. Twenty-
S. Schwartz
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Myeloproliferative disorders are associated with increased risk of thrombosis and vascular complications. The pathogenesis of these complications is not completely known.
Margarita Hurtado-Nedelec +8 more
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