Drug Development Pipeline for Myeloproliferative Neoplasms: Potential Future Impact on Guidelines and Management [PDF]
, 2016 Prithviraj Bose, Srđan Verstovšek
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DNA methyltransferase inhibitors in hematological malignancies and solid tumors
International Journal of Cancer, Volume 158, Issue 2, Page 433-461, 15 January 2026.Abstract Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5‐position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor ...
Valentin Wenger +3 more
wiley +1 more source
HOXB4 Promotes Bladder Cancer Progression in Part Through Transcriptional Activation of Smoothened
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.HOXB4 is overexpressed in bladder cancer and associated with poor prognosis. By transcriptionally activating Smoothened (SMO), HOXB4 amplifies SMO–GLI signaling to promote tumor growth and metastatic behavior. This graphical abstract highlights the HOXB4–SMO axis as a key driver of bladder cancer progression and a potential target for future ...
Zhaoheng Jin +6 more
wiley +1 more source
Patient-reported outcomes data from REVEAL at the time of enrollment (baseline): A prospective observational study of patients with polycythemia vera in the United States [PDF]
, 2018 Boccia, Ralph V +7 more
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JAK2V617F mediates resistance to DNA damage-induced apoptosis by modulating FOXO3A localization and Bcl-xL deamidation. [PDF]
, 2016 The JAK2V617F mutation is found in most patients with a myeloproliferative neoplasm (MPN). This gain-of-function mutation dysregulates cytokine signaling and is associated with increased accumulation of DNA damage, a process likely to drive disease ...
Ahn, JS +5 more
core
Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment
Cancer Medicine, Volume 15, Issue 1, January 2026.Krüppel‐like factor 4 (KLF4) exhibits a dual, context‐dependent role, acting as both a tumor suppressor and an oncogene. It remodels the tumor microenvironment by modulating cancer, stromal, and immune cells, representing a promising yet complex therapeutic target for cancer treatment.
Min Tang +5 more
wiley +1 more source
Rare Causes of Acute Coronary Syndrome: The JAK2 V617F Mutation-Positive Myeloproliferative Neoplasms: A Cardio-Hematological Perspective [PDF]
, 2022 Silvia Cantoni +8 more
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Tofacitinib Use in a Patient With Rheumatoid Arthritis and Polycythemia Vera: A Case Report
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction, whereas polycythemia vera (PV) is a myeloproliferative neoplasm driven by the Janus kinase (JAK)2 V617F mutation, resulting in erythrocytosis and increased thromboembolic risk.
Milan Bogojevic +4 more
wiley +1 more source
Cancer Reports, Volume 9, Issue 1, January 2026.ABSTRACT Background Chronic myeloid leukaemia (CML) is an infrequent myeloproliferative neoplasm in the paediatric population as compared to adults. Despite vast progress in understanding the disease biology and therapy of CML‐chronic phase (CML CP), the applicability of risk scoring systems in practice and prognostic factors in children remain grey ...
Souvik Saha +6 more
wiley +1 more source
1. Therapeutic Strategy for Myeloproliferative Neoplasms
, 2015 Kazuya Shimoda
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