Results 81 to 90 of about 41,188 (289)

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

MARIMO cells harbor a CALR mutation but are not dependent on JAK2/STAT5 signaling. [PDF]

, 2015
Work in the Green lab is supported by Leukemia and Lymphoma Research, Cancer Research UK, the NIHR Cambridge Biomedical Research Centre, the Cambridge Experimental Cancer Medicine Centre, and the Leukemia and Lymphoma Society of America.
A Tefferi, A Tefferi, Claire N. Harrison, E Puigdecanet, F Passamonti, H Yoshida, J Nangalia, John T. Reilly, M Michalak, M Wictome, P Guglielmelli, R Rampal, S Schwemmers, S Verstovsek, S Verstovsek, T Klampfl   +15 more
core   +1 more source

Interleukin (IL)‐5, Eosinophils and IL‐5 Pathway Inhibitors in Eosinophilic Granulomatosis with Polyangiitis.

Arthritis &Rheumatology, Accepted Article.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Burden of haematological malignancies among children, adolescents and young adults: Global and high‐income region insights from the GBD 2021 study

British Journal of Haematology, EarlyView.
Summary This study provides a comprehensive assessment of haematological malignancies among children, adolescents and young adults aged 0–24 years, using data from the Global Burden of Disease 2021 across 204 countries from 1990 to 2021. We found that global incidence and prevalence remained relatively stable, with approximately 150 000 new cases and ...
Shujuan Xu, Baihua Yang, Xinxin Liu, Zhenshu Xu, Ping Weng   +4 more
wiley   +1 more source

Can somatic GATA2 mutation mimic germ line GATA2 mutation? [PDF]

, 2018
Somatic GATA2 mutation is associated with immunodeficiency and pulmonary alveolar proteinosis in a patient with myeloproliferative ...
Collin, M, Dickinson, R, Lipman, M, Lowe, D, Marafioti, T, Mitchell, C, Pocock, R, Sekhar, M   +7 more
core  

miR-494-3p overexpression promotes megakaryocytopoiesis in primary myelofibrosis hematopoietic stem/progenitor cells by targeting SOCS6 [PDF]

, 2017
Primary myelofibrosis (PMF) is a chronic Philadelphia-negative myeloproliferative neoplasm characterized by hematopoietic stem cell-derived clonal myeloproliferation, involving especially the megakaryocyte lineage.
Barosi, Giovanni, Bianchi, Elisa, Guglielmelli, Paola, Manfredini, Rossella, Norfo, Ruggiero, Pennucci, Valentina, Prudente, Zelia, Rontauroli, Sebastiano, Rossi, Chiara, Rosti, Vittorio, Ruberti, Samantha, Salati, Simona, Tagliafico, Enrico, Vannucchi, Alessandro, Zini, Roberta   +14 more
core   +1 more source

Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms

Haematologica, 2017
The myeloproliferative neoplasms are a heterogeneous group of clonal disorders characterized by the overproduction of mature cells in the peripheral blood, together with an increased risk of thrombosis and progression to acute myeloid leukemia.
Jacob Grinfeld, Jyoti Nangalia, Anthony R. Green   +2 more
doaj   +1 more source

Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice [PDF]

, 2018
Juvenile Myelomonocytic Leukemia (JMML) is a pediatric myeloproliferative neoplasm (MPN) that has a poor prognosis. Somatic mutations in Ptpn11 are the most frequent cause of JMML and they commonly occur in utero.
Chan, Rebecca J., Qu, Cheng-Kui, Tarnawsky, Stefan P., Yoder, Mervin C., Yu, Wen-Mei   +4 more
core   +1 more source

Polycythemia Vera and Essential Thrombocythemia: A Nationwide Population‐Based Study on Treatment Patterns, Vascular Complications and Survival

European Journal of Haematology, EarlyView.
ABSTRACT Background Polycythemia vera (PV) and essential thrombocythemia (ET) are associated with a well‐recognized increased risk of thrombotic events, bleeding, and all‐cause mortality, but the frequency of these outcomes during treatment has rarely been assessed in large cohorts.
Anneli Enblom Larsson, Henrik Renlund, Björn Andréasson, Henrik Holmberg, Maria Liljeholm, Anders Själander   +5 more
wiley   +1 more source

Host Transcriptomics and Culture‐Independent Testing for the Management of Febrile Neutropenia: Data From an Observational Study Conducted in a Bone Marrow Transplant Unit

European Journal of Haematology, EarlyView.
ABSTRACT Background Managing febrile neutropenia is challenging due to the limited sensitivity of blood culture (BC) and the lack of tools differentiating infectious from non‐infectious fever. T2 magnetic resonance (T2MR) is a culture‐independent system detecting bacteria (T2Bacteria) and yeasts (T2Candida); SeptiCyte RAPID is a host response assay ...
Anna Maria Peri, Andrea S. Henden, Ricky Nelles, Mark D. Chatfield, Patrick N. A. Harris, Glen Kennedy, David L. Paterson   +6 more
wiley   +1 more source