Results 61 to 70 of about 352,135 (348)

Use of CBL exon 8 and 9 mutations in diagnosis of myeloproliferative neoplasms and myelodysplastic/myeloproliferative disorders: an analysis of 636 cases

Haematologica, 2012
We analyzed 636 patients with diverse myeloproliferative neoplasms or myelodysplastic/myeloproliferative neoplasms for mutations of the Casitas B-cell lymphoma gene (CBLmut) in exons 8 and 9 and performed correlations to other genetic alterations. CBLmut
Susanne Schnittger, Ulrike Bacher, Tamara Alpermann, Andreas Reiter, Madlen Ulke, Frank Dicker, Christiane Eder, Alexander Kohlmann, Vera Grossmann, Andreas Kowarsch, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach   +12 more
doaj   +1 more source

A systematic review of antithrombotic treatment of venous thromboembolism in patients with myeloproliferative neoplasms.

Blood Advances, 2021
Patients with myeloproliferative neoplasms (MPNs), polycythemia vera, essential thrombocythemia, and primary myelofibrosis, have an increased risk of thrombosis. Risk of recurrent thrombosis can be reduced with antithrombotic therapy and/or cytoreduction,
Eva N. Hamulyák, J. Daams, F. Leebeek, B. Biemond, P. T. te Boekhorst, S. Middeldorp, M. Lauw   +6 more
semanticscholar   +1 more source

Renal disease associated with myeloproliferative neoplasms and myelodysplastic syndrome/myeloproliferative neoplasms [PDF]

Histopathology, 2020
AimsRenal changes in patients with myeloproliferative neoplasms (MPNs) or myelodysplastic syndrome (MDS)/MPNs have been addressed by few, respectively no, reports. The aim of this study was to focus on a systematic evaluation of renal biopsies in patients with MPNs or MDS/MPNs.Methods and resultsThe cohort comprised 29 patients (23 men) aged 67 ± 11 ...
Maike Büttner‐Herold, Carsten Sticht, Thorsten Wiech, Stefan Porubsky   +3 more
openaire   +6 more sources

Molecular approach to diagnose BCR/ABL negative chronic myeloproliferative neoplasms

Revista Brasileira de Hematologia e Hemoterapia, 2011
Chronic myeloproliferative neoplasms arise from clonal proliferation of hematopoietic stem cells. According to the World Health Organization myeloproliferative neoplasms are classified as: chronic myelogenous leukemia, polycythemia vera, essential ...
Michelle Maccarini Barcelos, Maria Cláudia Santos-Silva   +1 more
doaj   +1 more source

Splenomegaly impacts prognosis in essential thrombocythemia and polycythemia vera: A single center study [PDF]

, 2019
Splenomegaly is one of the major clinical manifestations of primary myelofibrosis and is common also in other chronic Philadelphia-negative myeloproliferative neoplasms, causing symptoms and signs and affecting quality of life of patients diagnosed with ...
Accurso V., Casimiro P., Contrino A. D., Di Piazza F., Perez A., Raso S., Russo A., Santoro M., Siragusa S.   +8 more
core   +1 more source

Myeloproliferative neoplasms cause glomerulopathy [PDF]

Kidney International, 2011
Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders that can produce an undefined glomerulopathy. To better characterize the glomerular disease associated with myeloproliferative neoplasms, we evaluated features of 11 patients with myeloproliferative neoplasm-related glomerulopathy that included 8 patients with primary ...
Samar M. Said, Nelson Leung, Sanjeev Sethi, Lynn D. Cornell, Mary E. Fidler, Joseph P. Grande, Sandra M. Herrmann, Ayalew Tefferi, Vivette D. D’Agati, Samih H. Nasr   +9 more
openalex   +3 more sources

LKB1/STK11 is a tumor suppressor in the progression of myeloproliferative neoplasms.

Cancer Discovery, 2021
The myeloproliferative neoplasms frequently progress to blast phase disease, an aggressive form of acute myeloid leukemia. To identify genes that suppress disease progression, we performed a focused CRISPR/Cas9 screen and discovered that depletion of ...
C. Marinaccio, P. Suraneni, Hamza Celik, Andrew G Volk, Q. Wen, Te Ling, Marinka Bulic, T. Lasho, R. Koche, C. Famulare, N. Farnoud, B. Stein, Michael Schieber, S. Gurbuxani, D. Root, S. Younger, R. Hoffman, N. Gangat, P. Ntziachristos, N. Chandel, R. Levine, R. Rampal, Grant A. Challen, A. Tefferi, J. Crispino   +24 more
semanticscholar   +1 more source

Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms. [PDF]

, 2014
Myeloproliferative neoplasms (MPNs) are clonal hematological diseases in which cells of the myelo-erythroid lineage are overproduced and patients are predisposed to leukemic transformation.
de Haan, Gerald, Green, Anthony R, Kent, David G, Prick, Janine   +3 more
core   +1 more source

Morphology of myeloproliferative neoplasms

International Journal of Laboratory Hematology, 2023
AbstractMyeloproliferative neoplasms (MPN) are a group of clonal haematological malignancies first described by Dameshek in 1957. The Philadelphia‐negative MPN that will be described are polycythaemia vera (PV), essential thrombocythaemia (ET), pre‐fibrotic myelofibrosis and primary myelofibrosis (PMF).
Zi Yun Ng, Kathryn A. Fuller, Allegra Mazza‐Parton, Wendy N. Erber   +3 more
openaire   +2 more sources

Aberrant DNA methylation profile of chronic and transformed classic Philadelphia-negative myeloproliferative neoplasms

Haematologica, 2013
Most DNA methylation studies in classic Philadelphia-negative myeloproliferative neoplasms have been performed on a gene-by-gene basis. Therefore, a more comprehensive methylation profiling is needed to study the implications of this epigenetic marker in
Cristina Pérez, Marien Pascual, José Ignacio Martín-Subero, Beatriz Bellosillo, Victor Segura, Eric Delabesse, Sara Álvarez, María José Larrayoz, José Rifón, Juan Cruz Cigudosa, Carles Besses, María José Calasanz, Nicholas C.P. Cross, Felipe Prósper, Xabier Agirre   +14 more
doaj   +1 more source