Results 41 to 50 of about 115,857 (253)
Myeloproliferative neoplasms cause glomerulopathy [PDF]
, 2011 Myeloproliferative neoplasms are clonal hematopoietic stem cell disorders that can produce an undefined glomerulopathy. To better characterize the glomerular disease associated with myeloproliferative neoplasms, we evaluated features of 11 patients with ...
Sethi, Sanjeev +19 more
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Myeloproliferative neoplasms in children [PDF]
Journal of Hematopathology, 2015 Myeloproliferative neoplasms (MPN) are a group of clonal hematopoietic stem cell disorders characterized by aberrant proliferation of one or more myeloid lineages often with increased immature cells in the peripheral blood. The three classical BCR-ABL-negative MPNs are: 1) polycythemia vera (PV), 2) essential thrombocythemia (ET), and 3) primary ...
openaire +2 more sources
Mouse models of myeloproliferative neoplasms: JAK of all grades [PDF]
, 2011 In 2005, several groups identified a single gain-of-function point mutation in the JAK2 kinase that was present in the majority of patients with myeloproliferative neoplasms (MPNs).
Anthony R. Green +7 more
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JAK2 in Myeloproliferative Neoplasms: Still a Protagonist [PDF]
, 2022 The discovery of the activating V617F mutation in Janus kinase 2 (JAK2) has been decisive for the understanding of myeloproliferative neoplasms (MPN).
Sara Christina Meyer +3 more
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The molecular pathogenesis of myeloproliferative neoplasms
, 2010 Myeloproliferative neoplasms (MPNs) are a heterogeneous group of haematological stem cellmalignancies characterised by proliferation of one or more cells of the myeloid lineage.
Jones, Amy Victoria
core +2 more sources
The Thrombopoietin Receptor, MPL, Is a Therapeutic Target of Opportunity in the MPN
Frontiers in Oncology, 2021 The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis share driver mutations that either activate the thrombopoietin receptor, MPL, or indirectly activate it through mutations in the gene for JAK2, its ...
Jerry L. Spivak, Alison R. Moliterno
doaj +1 more source
Myelodysplastic/Myeloproliferative Neoplasms [PDF]
American Journal of Clinical Pathology, 2009 AbstractMyelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are rare de novo myeloid neoplasms that exhibit hybrid dysplastic and proliferative features at presentation. This SHP/EAHP Workshop session was uniquely problematic owing to the overlap between MDS/MPNs and both chronic myeloproliferative neoplasms and myelodysplasia.
openaire +2 more sources
Hybrid or Mixed Myelodysplastic/Myeloproliferative Disorders – Epidemiological Features and Overview
Frontiers in Oncology, 2021 The WHO-category Myelodysplastic/Myeloproliferative neoplasms (MDS/MPNs) recognizes a unique group of clonal myeloid malignancies exhibiting overlapping features of myelodysplastic as well as myeloproliferative neoplasms.
Andrea Kuendgen +2 more
doaj +1 more source
Neutrophil-to-lymphocyte ratio is a novel predictor of venous thrombosis in polycythemia vera
Blood Cancer Journal, 2022 We investigated the neutrophil-to-lymphocyte ratio (NLR) as a predictor of thrombosis in polycythemia vera (PV). After a median follow-up of 2.51 years, of 1508 PV patients enrolled in the ECLAP study, 82 and 84 developed arterial and venous thrombosis ...
Alessandra Carobbio +10 more
doaj +1 more source