Results 61 to 70 of about 115,857 (253)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Changes in neutrophil-to-lymphocyte ratio in patients with polycythemia vera treated with ruxolitinib reflect JAK2 variant allele frequency

Haematologica
Not available.
Paola Guglielmelli, Chiara Paoli, Giulia Borgi, Lorenzo Fagiolo, Sara Bianchini, Giuseppe Gaetano Loscocco, Francesca Gesullo, Fernanda di Vaio, Cecilia Matteoli, Fabiana Pancani, Sofia Danesi, Simona Pestelli, Tiziano Barbui, Alessandro M. Vannucchi   +13 more
doaj   +1 more source

How does JAK2V617F contribute to pathogenesis of myeloproliferative neoplasms? (Review)

, 2014
A decade on from the discovery of the JAK2V617F mutation in the majority of patients with myeloproliferative neoplasms (MPNs), JAK2V617F is now firmly installed in the hematology curriculum of medical students and the diagnostic-testing algorithm of ...
Chen, E., Mullally, A.
core   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

One thousand patients with essential thrombocythemia: the Florence-CRIMM experience

Blood Cancer Journal
We describe 1000 patients with essential thrombocythemia seen at the Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), Florence, Italy, between 1980 and 2023: median age 59 years (18–95), females 65%, JAK2/CALR/MPL-mutated 66%/19%/4%
Giuseppe G. Loscocco, Francesca Gesullo, Giulio Capecchi, Alessandro Atanasio, Chiara Maccari, Francesco Mannelli, Alessandro M. Vannucchi, Paola Guglielmelli   +7 more
doaj   +1 more source

Frequency of heterozygous TET2 deletions in myeloproliferative neoplasms

, 2010
Joseph Tripodi1, Ronald Hoffman1, Vesna Najfeld2, Rona Weinberg31The Myeloproliferative Disorders Program, Tisch Cancer Institute, Department of Medicine and 2Department of Medicine and Pathology, Mount Sinai School of Medicine, 3The Myeloproliferative ...
Ronald Hoffman, Joseph Tripodi, et al, null Tripodi, Vesna Najfeld   +4 more
core   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source

Classification and Personalized Prognosis in Myeloproliferative Neoplasms [PDF]

, 2018
BACKGROUND: Myeloproliferative neoplasms, such as polycythemia vera, essential thrombocythemia, and myelofibrosis, are chronic hematologic cancers with varied progression rates.
Hasselbalch, HC, Gerstung, M., Maclean, C, Grinfeld, Jacob, Mudie, Laura, Cook, J, Williams, Nicholas, Papaemmanuil, E., Nangalia, Jyoti, Harrison, C.N., MacLean, C., Harrison, CN, Campbell, PJ, Meara, Sarah O, Cook, J., Teague, Jon W., Grinfeld, J, Andersen, CL, McMullin, Mary F., Nice, Francesca L, Godfrey, AL, Cook, Julia, Cantrill, Rob, Cantrill, R, Butler, Adam P, Guglielmelli, P, Massie, C.E., Harrison, Claire N, McMullin, Mary Frances, O'Neil, Laura, Vannucchi, A.M., Baxter, E.J., Vannucchi, AM, Harrison, Claire N., Nangalia, J, Butler, Adam P., Teague, Jon W, Guglielmelli, Paola, Massie, CE, Nice, F.L., Godfrey, A.L., O'Neil, L., Baxter, E. Joanna, Hasselbalch, Hans C, Williams, N, Cantrill, R., Angelopoulos, N., Angelopoulos, N, Hasselbalch, H.C., Baxter, E Joanna, Massie, Charlie E., Campbell, P.J., O'Meara, Sarah, Nangalia, J., Wedge, David, Papaemmanuil, E, Angelopoulos, Nicos, Green, AR, McMullin, MF, Gerstung, Moritz, Cantrill, Robert, Butler, AP, Nice, FL, Campbell, Peter J., McMullin, M.F., Andersen, Christen L., Baxter, Joanna, Godfrey, Anna L., Gerstung, M, Green, Anthony R., O'Neil, L, Gundem, Gunes, McMullin, Mary F, Teague, J.W., Williams, N., Wedge, D.C.; id_orcid, Baxter, EJ, Gundem, G, O'Meara, S., Guglielmelli, P., Campbell, Peter J, Wedge, David C, Andersen, Christen L, MacLean, Cathy, Green, A.R., Teague, JW, O'Meara, S, Wedge, David C., Gundem, G., Papaemmanuil, Elli, Wedge, DC, Grinfeld, J., Godfrey, Anna L, Andersen, C.L., Vannucchi, Alessandro M, Massie, Charlie E, Nice, Francesca L., Hasselbalch, Hans C., Butler, A.P., Vannucchi, Alessandro M., Green, Anthony R   +100 more
core   +4 more sources

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

American Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse   +16 more
wiley   +1 more source