Results 31 to 40 of about 115,857 (253)
The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity [PDF]
, 2010 The classical myeloproliferative disorders (MPD), comprising essential thrombocythaemia (ET), polycythaemia vera (PV) and idiopathic myelofibrosis (IMF), are clonal premalignant haematopoietic neoplasms associated with activating mutations in signalling ...
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Myelodysplastic/Myeloproliferative Neoplasms [PDF]
, 2018 The myelodysplastic syndrome-myeloproliferative neoplasms (MDS/MPNs) are a heterogeneous group of hematologic malignancies characterized by dysplastic and myeloproliferative clinical, laboratory, and morphological overlapping features, both in marrow and
Yves Chalandon +2 more
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Studies of JAK2 mutations in myeloproliferative disorders [PDF]
, 2008 Myeloproliferative disorders (MPD) are diseases characterized by clonal hematopoiesis with overprodution of mature cells from erythroid, megakaryocytic and myeloid lineages.
Li, Sai
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Aetiology of Myeloproliferative Neoplasms [PDF]
Cancers, 2020 Myeloproliferative neoplasms (MPNs) have estimated annual incidence rates for polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis of 0.84, 1.03, and 0.47 per 100,000. Prevalence is much higher, particularly for PV and ET, as mortality rates are relatively low.
Mary Frances McMullin +1 more
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Abnormalities affecting tyrosine kinase signalling in atypical myeloproliferative disorders [PDF]
, 2009 The myeloproliferative disorders (MPDs) are a group of haematopoietic stem cell diseases, characterised by proliferation of one or more cells of the myeloid lineage.
Hidalgo-Curtis, Claire
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Epigenetics in Myeloproliferative Neoplasms [PDF]
Journal of Cellular and Molecular Medicine, 2017 AbstractA decade on from the description of JAK2 V617F, the MPNs are circumscribed by an increasingly intricate landscape. There is now evidence that they are likely the result of combined genetic dysregulation, with several mutated genes involved in the regulation of epigenetic mechanisms. Epigenetic changes are not due to a change in the DNA sequence
Suzanne McPherson +2 more
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Mechanisms of disease transformation in myeloproliferative neoplasms [PDF]
, 2023 Myeloproliferative neoplasms are heterogeneous clonal haematological malignancies where disease initiation occurs by acquisition of a somatic mutation in a haematopoietic stem cell.
O'Sullivan, Jennifer
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Myeloproliferative Neoplasms [PDF]
JAMA Oncology, 2015 Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) constitute the BCR-ABL1-negative myeloproliferative neoplasms and are characterized by mutually exclusive Janus kinase 2 (JAK2), calreticulin (CALR), and myeloproliferative leukemia virus oncogene (MPL) mutations; respective frequencies of these mutations are ...
Ayalew, Tefferi, Animesh, Pardanani
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Haematologica, 2014 According to the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues, myeloproliferative neoplasms (MPN) include chronic myeloid leukemia and the so-called Philadelphia-negative myeloproliferative neoplasms, i.e.
Luca Malcovati +2 more
doaj +4 more sources
Myeloproliferative neoplasms and thrombosis
Blood, 2013 Abstract Major causes of morbidity and mortality in myeloproliferative neoplasms are represented by arterial and venous complications, progression to myelofibrosis, and transformation to acute leukemia. The pathogenesis of thrombosis results from a complex interplay of clinical and disease-related factors.
Barbui, Tiziano +2 more
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