Results 71 to 80 of about 352,135 (348)

Functional Consequences of Mutations in Myeloproliferative Neoplasms

HemaSphere, 2021
Driver mutations occur in Janus kinase 2 (JAK2), thrombopoietin receptor (MPL), and calreticulin (CALR) in BCR-ABL1 negative myeloproliferative neoplasms (MPNs).
S. Constantinescu, W. Vainchenker, G. Levy, Nicolas Papadopoulos   +3 more
semanticscholar   +1 more source

The Calreticulin gene and myeloproliferative neoplasms [PDF]

, 2016
The Philadelphia negative myeloproliferative neoplasms include polycythaemia vera (PV), essential thrombocytopenia (ET) and primary myelofibrosis (PMF).
Clinton, Aoibhinn, McMullin, Mary Frances   +1 more
core   +1 more source

Molecular biology of Philadelphia-negative myeloproliferative neoplasms

Revista Brasileira de Hematologia e Hemoterapia, 2012
Myeloproliferative neoplasms are clonal diseases of hematopoietic stem cells characterized by myeloid hyperplasia and increased risk of developing acute myeloid leukemia.
Paulo Vidal Campregher, Fábio Pires de Souza Santos, Guilherme Fleury Perini, Nelson Hamerschlak   +3 more
doaj   +1 more source

Shared and Distinctive Ultrastructural Abnormalities Expressed by Megakaryocytes in Bone Marrow and Spleen From Patients With Myelofibrosis

Frontiers in Oncology, 2020
Numerous studies have documented ultrastructural abnormalities in malignant megakaryocytes from bone marrow (BM) of myelofibrosis patients but the morphology of these cells in spleen, an important extramedullary site in this disease, was not investigated
Maria Zingariello, Vittorio Rosti, Alessandro M. Vannucchi, Paola Guglielmelli, Maria Mazzarini, Giovanni Barosi, Maria Luisa Genova, Anna Rita Migliaccio, Anna Rita Migliaccio   +8 more
doaj   +1 more source

Spleen in myeloproliferative neoplasms

HemaSphere, 2018
Giovanni Barosi
doaj   +2 more sources

Targeting self-renewal pathways in myeloid malignancies [PDF]

, 2013
A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core   +2 more sources

Leveraging big data and artificial intelligence for smarter trials in myeloproliferative neoplasms

Frontiers in Hematology
The myeloproliferative neoplasms (MPNs) – polycythemia vera, essential thrombocytosis, and primary myelofibrosis – are chronic blood cancers that originate from hematopoietic stem cells carrying driver mutations which activate cytokine signaling pathways
Joshua W. Bliss, Spencer Krichevsky, Spencer Krichevsky, Joseph Scandura, Ghaith Abu-Zeinah   +4 more
doaj   +1 more source

Accelerated Phase of Myeloproliferative Neoplasms

Acta Haematologica, 2021
Background: Myeloproliferative neoplasms (MPNs) can transform into blast phase MPN (leukemic transformation; MPN-BP), typically via accelerated phase MPN (MPN-AP), in ∼20–25% of the cases.
Omar A. Shahin, H. Chifotides, P. Bose, L. Masarova, S. Verstovsek   +4 more
semanticscholar   +1 more source

Erythematous Macular Eruption in an Older Woman [PDF]

, 2019
A white woman in her 70s with advanced Alzheimer disease was referred to the hematology clinic for evaluation of a high hemoglobin level (169 g/L; normal range, 120-160 g/L) and red blood cell count (5.67 × 1012/L; normal range, 3.8-4.8 × 1012/L) as well
Kernohan, Neil, McLaughlin, David, Tauro, Sudhir   +2 more
core   +2 more sources

JAK2 V617F Analysis in Indonesian Myeloproliferative Neoplasms Patients [PDF]

, 2015
Background : Three subtypes of myeloproliferative neoplasms (MPNs): Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) showed overlapping phenotype.
Faradz, S. M. (Sultana), Saktini, F. (Fanti), Santosa, S. (Santosa)   +2 more
core   +3 more sources