Results 81 to 90 of about 352,135 (348)

Myeloproliferative neoplasms in children [PDF]

Journal of Hematopathology, 2015
Myeloproliferative neoplasms (MPN) are a group of clonal hematopoietic stem cell disorders characterized by aberrant proliferation of one or more myeloid lineages often with increased immature cells in the peripheral blood. The three classical BCR-ABL-negative MPNs are: 1) polycythemia vera (PV), 2) essential thrombocythemia (ET), and 3) primary ...
openaire   +3 more sources

Validation and molecular integration of the RR6 model to predict survival after 6 months of therapy with ruxolitinib

Haematologica
Not available.
Giacomo Coltro, Giulio Capecchi, Margherita Maffioli, Francesco Mannelli, Barbara Mora, Alessandro Atanasio, Alessandra Iurlo, Chiara Maccari, Mirko Farina, Elena Nacca, Marianna Caramella, Leonardo Signori, Miriam Borella, Lorenza Bertù, Maria Esposito, Paola Guglielmelli, Francesco Passamonti, Alessandro Maria Vannucchi   +17 more
doaj   +1 more source

Emerging Role of Neutrophils in the Thrombosis of Chronic Myeloproliferative Neoplasms

International Journal of Molecular Sciences, 2021
Thrombosis is a major cause of morbimortality in patients with chronic Philadelphia chromosome-negative myeloproliferative neoplasms (MPN). In the last decade, multiple lines of evidence support the role of leukocytes in thrombosis of MPN patients ...
F. Ferrer-Marín, Ernesto José Cuenca-Zamora, Pedro J Guijarro-Carrillo, R. Teruel-Montoya   +3 more
semanticscholar   +1 more source

Novel therapeutics in myeloproliferative neoplasms [PDF]

Journal of Hematology & Oncology, 2020
AbstractHyperactive signaling of the Janus-Associated Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) pathway is central to the pathogenesis of Philadelphia-chromosome-negative myeloproliferative neoplasms (MPN), i.e., polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) which are characterized by
Sangeetha Venugopal, John Mascarenhas
openaire   +3 more sources

Mutations of c-Cbl in myeloid malignancies [PDF]

, 2006
Next generation sequencing has shown the frequent occurrence of point mutations in the ubiquitin E3 ligase c-Cbl in myeloid malignancies. Mouse models revealed a causal contribution of c-Cbl for the onset of such neoplasms.
Bloomfield, Weissman, Weissman, Weissman, Weissman, Weissman, Zon, Sigvardsson, Cancer Genome, Baltimore, Birnbaum, Huibregtse, Weissman, Weissman, Dikic, Lipkowitz, Huang, Inagaki, Lipkowitz, Liu, Yarden, Chen, Swaminathan, Samelson, Schmitz, Oliver, Spiekermann, Maciejewski, Chase, Lipkowitz, Whitman, Maciejewski, Bock, Masuda, Birnbaum, Kawamata, Band, Reiter, Bowtell, Band, Langdon, Chaffanet, Rodriguez, Aplan, Voet, Shih, Haferlach, Hirai, Corey, Corey, Hattori, Lowell, Shimizu, Loh, Barber, Roussel, Flavell, Sieweke, Stanley, Berton, Stanley, Cortes, Penninger, Anderson   +63 more
core   +4 more sources

JAK2V617F mutation in a patient with B-cell chronic lymphocytic leukemia and prefibrotic primary myelofibrosis [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2015
Introduction. Secondary malignancies, particularly solid tumors, are common in patients with chronic lymphocytic leukemia (CLL), but association of myeloproliferative neoplasms and chronic lymphocytic leukemia in the same patient is very rare ...
Ristić Slobodan, Radojković Milica, Kostić Tatjana, Spasovski Vesna, Pavlović Sonja, Čemerikić-Martinović Vesna   +5 more
doaj   +1 more source

Tissue‐Resident Myeloid and Histiocytic Cells in Health and Disease: Novel Emerging Concepts

American Journal of Hematology, EarlyView.
ABSTRACT Although all myeloid cells are considered to derive from hematopoietic stem cells, the cells in each myeloid lineage are heterogeneous populations, and their distribution and functions vary, depending on underlying physiologic and pathologic processes, age, sex, and genetic and epigenetic signatures.
Peter Valent, Johann Wojta, Petri T. Kovanen, Olivier Hermine, Falko Fend, Karl Sotlar, Hildegard Greinix, Klaus Geissler, Karin Hartmann, Juliana Schwaab, Marco Herling, Laura Boccuni, Lukas Kazianka, Max Vincent John, Wolfgang R. Sperr, Carina Zierfuss, Alexandar Tzankov, Christian Sillaber, Milen Minkov, Gregor Hoermann, Matthew Collin, Hans‐Peter Horny, Torsten Haferlach, Maria Sibilia, Julien Haroche, Paul La Rosée, Alberto Orfao, Michel Arock   +27 more
wiley   +1 more source

One thousand patients with essential thrombocythemia: the Florence-CRIMM experience

Blood Cancer Journal
We describe 1000 patients with essential thrombocythemia seen at the Center Research and Innovation of Myeloproliferative Neoplasms (CRIMM), Florence, Italy, between 1980 and 2023: median age 59 years (18–95), females 65%, JAK2/CALR/MPL-mutated 66%/19%/4%
Giuseppe G. Loscocco, Francesca Gesullo, Giulio Capecchi, Alessandro Atanasio, Chiara Maccari, Francesco Mannelli, Alessandro M. Vannucchi, Paola Guglielmelli   +7 more
doaj   +1 more source

Triple A Plus (AAA+) Survival Prediction Model for Essential Thrombocythemia: Analysis Involving 7308 Patients

American Journal of Hematology, EarlyView.
A new risk model for essential thrombocythemia that is based on complete blood cell count‐derived parameters and host‐related factors. ABSTRACT Survival prediction models in essential thrombocythemia (ET) include the International Prognostic Scoring System (IPSET) and the more recently introduced triple‐A (AAA) prognostic score.
Ayalew Tefferi, Giuseppe G. Loscocco, Lior Rokach, Tamar Tadmor, Priyansh Faldu, Guy Melamed, Hilel Alapi, Maymona Abdelmagid, Rania M. Abdelaziz, Muhammad Yousuf, Merry Nakhleh, Animesh Pardanani, Kebede H. Begna, Mirnal M. Patnaik, Natasha Szuber, Alessandra Carobbio, Tiziano Barbui, Kaaren K. Reichard, Rong He, Paola Guglielmelli, Naseema Gangat, Alessandro M. Vannucchi   +21 more
wiley   +1 more source

Methylation of TET2, CBL and CEBPA in Ph-negative myeloproliferative neoplasms [PDF]

, 2010
A loss-of-function mutation of TET2, CBL and CEBPA has been implicated in the pathogenesis or leukaemic transformation of myeloproliferative neoplasm.
Chim, CS, Fung, TK, Wan, TS, Wong, KF
core   +1 more source