Results 91 to 100 of about 36,039 (270)

Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression

, 2023
[Image: see text] Wee1 is a tyrosine kinase that is highly expressed in several cancer types. Wee1 inhibition can lead to suppression of tumor cell proliferation and sensitization of cells to the effects of DNA-damaging agents.
Zhang, Zhuo (author), Caldwell, Richard, Guler, Satenig, Huck, Bayard, Musil, Djordje, Caldwell, Richard (author), Simon, Stephanie (author), Liu-Bujalski, Lesley (author), Huck, Bayard (author), Grossmann, Nina (author), Simon, Stephanie, Doerfel, Benjamin, Jones, Christopher CV, Potnick, Justin, Sherer, Brian, Ho, Kevin (author), Sirrenberg, Christian, Jones, Christopher CV (author), Doerfel, Benjamin (author), Crespo, Alejandro, Liu-Bujalski, Lesley, Potnick, Justin (author), Sherer, Brian (author), Grossmann, Nina, DiPoto, Maria C., Crespo, Alejandro (author), Sirrenberg, Christian (author), Schilke, Heike, Musil, Djordje (author), Lan, Ruoxi, Lan, Ruoxi (author), DiPoto, Maria C. (author), Zhang, Zhuo, Ho, Kevin, Guler, Satenig (author), Schilke, Heike (author)   +35 more
core   +1 more source

Radiotherapy and Immunotherapy In Hepatocellular Carcinoma: Priming the Tumor Immune Microenvironment From Bench To Bedside

Precision Radiation Oncology, EarlyView.
The dual immunomodulatory network of radiotherapy in hepatocellular carcinoma. Radiotherapy initiates its effects by inducing immunogenic cell death and DNA double‐strand breaks. Immune Activation: Cytosolic DNA from damaged cells activates the cGAS‐STING pathway, triggering IRF3/NF‐κB‐mediated type I interferon production. This enhances dendritic cell
Zhigang Fu, Yang Zhang, Zuomin Wang, Zongjuan Li, Shisuo Du   +4 more
wiley   +1 more source

Predicting grade≥2 chemotherapy-induced myelosuppression in older patients with colorectal cancer receiving first-line chemotherapy: a multi-algorithm consensus approach using 9 routine parameters to develop and validate an explainable boosting machine

陆军军医大学学报
Objective Older patients with colorectal cancer undergoing first-line chemotherapy are prone to myelosuppression, which can lead to treatment delays, dose adjustments, and adverse outcomes such as infection and bleeding; however, individualized risk ...
Liu Yuming, Zheng Honggang
doaj   +1 more source

Case Report: Life-threatening neutropenia with absolute neutrophil count of zero after low-dose regional arterial infusion chemotherapy to lung in a patient with advanced triple-negative breast cancer after multiple lines of treatment

Frontiers in Oncology
BackgroundThe risk of severe myelosuppression following regional arterial perfusion chemotherapy in heavily pre-treated patients is often underestimated, especially when pre-treatment hematologic status appears adequate.
Yiran Wang, Qianlin Liu, Yanjun Feng, Jun Zhou   +3 more
doaj   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Myeloprotective Effects of Trilaciclib Among Patients with Small Cell Lung Cancer at Increased Risk of Chemotherapy-Induced Myelosuppression: Pooled Results from Three Phase 2, Randomized, Double-Blind, Placebo-Controlled Studies

Cancer Management and Research, 2021
Maen Hussein,1 Marina Maglakelidze,2 Donald A Richards,3 Marielle Sabatini,4 Todd A Gersten,5 Keith Lerro,6 Ivan Sinielnikov,7 Alexander Spira,8,9 Yili Pritchett,10 Joyce M Antal,10 Rajesh Malik,10 J Thaddeus Beck11 1Florida Cancer Specialists, Leesburg,
Hussein M, Maglakelidze M, Richards DA, Sabatini M, Gersten TA, Lerro K, Sinielnikov I, Spira A, Pritchett Y, Antal JM, Malik R, Beck JT   +11 more
doaj  

Rates of myelosuppression in patients treated with the HAG regimen vs. intensive chemotherapy.

, 2016
Rates of myelosuppression in patients treated with the HAG regimen vs. intensive chemotherapy.
Yanlong Zheng (1819264), Jianai Sun (3195636), Wanzhuo Xie (576454), Mixue Xie (3195633), Qi Jiang (33521), Mingyu Zhu (3195627), Lixia Zhu (844549), Xiudi Yang (3195630), Jingjing Zhu (303859), Li Li (14993), Xiujin Ye (576452), De Zhou (3195639)   +11 more
core   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

Grade IV myelosuppression rate in patients treated with the HAG regimen.

, 2016
Grade IV myelosuppression rate in patients treated with the HAG regimen.
Yanlong Zheng (1819264), Jianai Sun (3195636), Wanzhuo Xie (576454), Mixue Xie (3195633), Qi Jiang (33521), Mingyu Zhu (3195627), Lixia Zhu (844549), Xiudi Yang (3195630), Jingjing Zhu (303859), Li Li (14993), Xiujin Ye (576452), De Zhou (3195639)   +11 more
core   +1 more source

Nimotuzumab Combined With Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma and Nasopharyngeal Carcinoma: A Systematic Review and Meta‐Analysis

Asia-Pacific Journal of Clinical Oncology, EarlyView.
This meta‐analysis of 18 studies (3962 patients) demonstrates that nimotuzumab combined with chemoradiotherapy significantly improves overall survival and progression‐free survival in locally advanced head and neck squamous cell carcinoma, without increasing severe toxicity.
Chengzheng Bao, Yue Zhang, Xiang Fei, Kaifeng Ji, Ming Jia, Zhijun Li, Chao Bian   +6 more
wiley   +1 more source