Results 81 to 90 of about 36,039 (270)

Construction and validation of a predictive model for the risk of myelosuppression after first-line chemotherapy in patients with advanced colorectal cancer [PDF]

Yixue xinzhi zazhi
Objective To investigate the risk factors influencing the incidence of chemotherapy-induced myelosuppression (CIM) following first-line chemotherapy in patients with moderately advanced colorectal cancer (CRC), and to develop and validate a nomogram to ...
WANG Xuexing, ZHANG Rong, CHU Jie, LIU Zhijin   +3 more
doaj   +1 more source

Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression

, 2023
Wee1 is a tyrosine kinase that is highly expressed in several cancer types. Wee1 inhibition can lead to suppression of tumor cell proliferation and sensitization of cells to the effects of DNA-damaging agents. AZD1775 is a nonselective Wee1 inhibitor for
Bayard Huck (11512135), Djordje Musil (483563), Brian Sherer (7251149), Justin Potnick (11512141), Lesley Liu-Bujalski (7251155), Kevin Ho (135900), Ruoxi Lan (11512138), Satenig Guler (2019832), Zhuo Zhang (72795), Benjamin Doerfel (12969456), Maria C. DiPoto (15197259), Richard Caldwell (1405651), Christian Sirrenberg (483562), Alejandro Crespo (1445995), Nina Grossmann (15197262), Christopher CV Jones (15197265), Heike Schilke (11267557), Stephanie Simon (4181320)   +17 more
core   +1 more source

Triptolide Suppresses Tongue Squamous Cell Carcinoma Progression via PI3K–AKT Pathway Inhibition: An Integrative Network Pharmacology and Experimental Validation Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma, the most aggressive subtype of oral squamous cell carcinoma, which is associated with high mortality, frequent recurrence, and early lymph‐node metastasis. Triptolide, a bioactive diterpenoid from Tripterygium wilfordii, exhibits broad anticancer activity.
Shan‐Shan Wang, Hong‐Cheng Wei, Lin Jiang, Yi‐Sen Shao   +3 more
wiley   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

VEGF Inhibitor–Associated Side Effects in Antitumor Therapy and Intervention Strategies

Zhongliu Fangzhi Yanjiu
Vascular endothelial growth factor (VEGF) inhibitors are drugs that target and inhibit tumor angiogenesis. By blocking the signaling pathway of VEGF and its receptor, they suppress tumor proliferation and play a crucial role in tumor treatment.
Lu LIU, Wanting SUN, Shuning YAO, Zhenyu CHEN, Yuefei WANG, Jing YANG   +5 more
doaj   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Complications of MRSA Treatment: Linezolid-induced Myelosuppression Presenting with Pancytopenia

Western Journal of Emergency Medicine, 2008
Methicillin-resistant Staphylococcus aureus (MRSA) infections have grown to epidemic proportions in the United States. With the development of increasing drug resistance of MRSA to traditional antimicrobials, there has been a search for a more effective ...
Gorchynski, Julie A, Rose, Jeri K
doaj  

Influence of chemotherapy intensity on opportunistic fungal infection risk in non-small cell lung carcinoma: a retrospective study

Frontiers in Medicine
BackgroundOpportunistic fungal infections represent a serious treatment-related complication in patients with advanced non-small cell lung carcinoma (NSCLC) undergoing chemotherapy, closely associated with treatment intensity-induced immunosuppression ...
Fang Zheng, Fang Zheng, Wenli Li, Fei Zhao, Zhenzhen Zhu, Weiyang Wang, Qinghai You   +6 more
doaj   +1 more source

Exosomal miR-122-5p is Related to the Degree of Myelosuppression Caused by Chemotherapy in Patients with Colorectal Cancer

Cancer Management and Research, 2021
Jinbao Chen,1,* Wentao Wu,1,* Xue He,1 Linlin Jia,1 Jiahua Yang,1 Xianke Si,1 Kun Yu,1 Sen Li,1 Yanyan Qiu,1 Ke Xu,2 Peihao Yin,1,3 Yijun Cao,1 Qiong Li,4 Wei Li1 1Department of General Surgery, Putuo Hospital, Shanghai University of Traditional ...
Chen J, Wu W, He X, Jia L, Yang J, Si X, Yu K, Li S, Qiu Y, Xu K, Yin P, Cao Y, Li Q, Li W   +13 more
doaj  

Severity of myelosuppression related to low-dose MTX therapy for inflammatory rheumatic diseases (n = 40).

, 2016
Severity of myelosuppression related to low-dose MTX therapy for inflammatory rheumatic diseases (n = 40).
Toshihiko Hidaka (2634763), Toshiro Kawakita (2634769), Yukitaka Ueki (2634766), Hiroyuki Tsuda (52130), Michihiro Hidaka (2634757), Kiyoshi Migita (290200), Shunsuke Mori (487036), Tamami Yoshitama (2634760)   +7 more
core   +1 more source