Results 61 to 70 of about 36,039 (270)

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Comparative Pharmacokinetics of Six Bioactive Constituents From Danggui Jixueteng Decoction in Normal and Myelosuppressive Rats. [PDF]

Anal Sci Adv
ABSTRACT This study compared the pharmacokinetics of six constituents from Danggui Jixueteng Decoction in normal versus carboplatin‐induced myelosuppressive rats. A rapid, sensitive ultra‐high performance liquid chromatography‐tandem mass spectrometry method was developed and validated for simultaneous quantification of six diverse constituents (8‐O ...
Guo M, Liu Y, Hu Z, Liu X.
europepmc   +2 more sources

A Novel UPLC-MS/MS Assay for the Measurement of Linezolid and its Metabolite PNU-142300 in Human Serum and its Application to Patients With Renal Insufficiency

Frontiers in Pharmacology, 2021
The contribution of the metabolites of linezolid to the associated myelosuppression is unknown in patients who are renal impairment. In this research, the purpose of our experiment was to explore and develop a quick and robust ultra performance liquid ...
Yingying Wang, Er-min Gu, Xiaoxiang Du, Ren-ai Xu, Guanyang Lin   +4 more
doaj   +1 more source

Piperacillin/tazobactam Induced Myelosuppression

Journal of Clinical Medicine Research, 2009
Neutropenia, secondary to immune destruction or maturation arrest, is the most commonly described adverse haematological effect of beta-lactam antibiotics. We describe a case of reversible pancytopenia, with evidence of hypocellular marrow, after a prolonged course of piperacillin/tazobactam for 26 days.Piperacillin; Tazobactam; Myelosuppression ...
Lee, Kirsty Wai Chung, Chow, Kai Ming, Chan, Natalie Pui Ha, Lo, Angeline Oi Shan, Szeto, Cheuk Chun   +4 more
openaire   +3 more sources

The Role of Tumor Necrosis Factor and ITS Soluble Receptors in Myelosuppression Developing in B-Cell Chronic Lymphocytic Leukemia

, 2015
Introduction. Myelosuppression with severe anemia or thrombocytopenia refers to the adverse factors in clinical course of B-cell chronic lymphocytic leukemia (B-CLL).
Matlan V., Barilka V., Vygovska O., Shalay O., Prymak S.   +4 more
core   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Myelosuppression

Citation: 'myelosuppression' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13490 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Simon, Hans-Uwe, Zangemeister-Wittke, Uwe, Schwab, Manfred   +2 more
openaire   +2 more sources

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

Machine-Learning Approach for Modeling Myelosuppression Attributed to Nimustine Hydrochloride

, 2018
Purpose A major adverse effect arising from nimustine hydrochloride (ACNU) therapy for brain tumors is myelosuppression. Because its timing and severity vary among individual patients, the ACNU dose level has been adjusted in an empiric manner at ...
Yoshihiro Muragaki, Takuma Shibahara, Soko Ikuta   +2 more
core   +1 more source