Results 41 to 50 of about 36,039 (270)

Rare tuberculosis in recipients of allogeneic hematopoietic stem cell transplantation successfully treated with contezolid–a typical case report and literature review

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundTuberculosis (TB) is a rare but potentially devastating complication in hematopoietic stem cell transplantation (HSCT) recipients. Myelosuppression-related antibiotics should be used cautiously in patients with hematological malignancies ...
Junhong Li, Junhong Li, Zhaoxian Yu, Zhaoxian Yu, Yingyi Jiang, Yingyi Jiang, Suihua Lao, Suihua Lao, Dexian Li, Dexian Li   +9 more
doaj   +1 more source

Limited inter-occasion variability in relation to inter-individual variability in chemotherapy-induced myelosuppression

, 2010
Purpose: A previously developed semi-physiological model of chemotherapy-induced myelosuppression has shown consistent system-related parameter and inter-individual variability (IIV) estimates across drugs.
Karlsson, Mats O.,, Hansson, Emma K., Sandström, Marie, Hansson, Emma K.,, Wallin, Johan,, Wallin, Johan, Lindman, Henrik,, Friberg, Lena E., Lindman, Henrik, Sandström, Marie,, Friberg, Lena E.,, Karlsson, Mats O.   +11 more
core   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Therapeutic Effects of Plant Extracts of Anoectochilus roxburghii on Side Effects of Chemotherapy in BALB/c Breast Cancer Mice

Plants, 2023
Breast cancer is the most common cancer in women, and chemotherapy is an effective treatment. However, chemotherapy often causes adverse side effects such as cardiotoxicity, myelosuppression, immunodeficiency, and osteoporosis.
Chi-Feng Cheng, Chen-Wen Lu, Wen-Jhen Wu, Li-Yu Su, Thi Kim Ngan Nguyen, Szu-Chuan Shen, Chia-Ying Lien, Wu-Chang Chuang, Ming-Chung Lee, Chung-Hsin Wu   +9 more
doaj   +1 more source

Inhalable ROS‐Responsive Nanospray Activates PPAR‐γ to Restore Macrophage Mitochondrial Homeostasis and Attenuate Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
A nebulized nanoassembly alleviates radiation‐induced lung injury by reprogramming macrophages through coordinated ROS scavenging, NAD+ replenishment, and PPAR‐γ activation. Redox balance, mitochondrial homeostasis, and immune regulation are restored, revealing a microenvironment‐centered strategy for localized radioprotection.
Mingquan Gao, Xudong Yu, Ziqian Shang, Mengyao Tan, Xie Huang, Zaizhi Du, Xiaojiao Wang, Xinrui Yang, Ximei Luo, Weidong Wang, Rong Li, Shenglin Luo   +11 more
wiley   +1 more source

TPGS-Modified Long-Circulating Liposomes Loading Ziyuglycoside I for Enhanced Therapy of Myelosuppression

International Journal of Nanomedicine, 2021
Tingting Song,* Hong Wang,* Yue Liu, Rongshan Cai, Dezhi Yang, Yongai Xiong Department of Pharmacy, Zunyi Medical University, Zunyi City, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongai Xiong ...
Song T, Wang H, Liu Y, Cai R, Yang D, Xiong Y   +5 more
doaj  

Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia

Indian Journal of Medical and Paediatric Oncology, 2014
Introduction: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. 6-mercaptopurine (6-MP) and methotrexate are backbone drugs for maintenance phase of treatment. Purine Analogs 6-MP/6-thioguanine/azathiopurine are metabolized to
Vijay Gandhi Linga, Dorra Babu Patchva, Krishna Mohan Mallavarapu Venkata Tulasi, Krishnamani Iyer Kalpathi, Ashok Pillai, Sadashivudu Gundeti, Senthil J Rajappa, Raghunadharao Digumarti   +7 more
doaj   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Evaluating the Effects of Prostate Radiotherapy Intensified with Pelvic Nodal Radiotherapy and Androgen Deprivation Therapy on Myelosuppression: Single-Institution Experience

Current Oncology
Background: Prostate cancer (PCa) management commonly involves the utilization of prostate radiotherapy (PRT), pelvic nodal radiotherapy (PNRT), and androgen deprivation therapy (ADT). However, the potential association of these treatment modalities with
Yousef Katib, Steven Tisseverasinghe, Ian J. Gerard, Benjamin Royal-Preyra, Ahmad Chaddad, Tania Sasson, Boris Bahoric, Federico Roncarolo, Tamim Niazi   +8 more
doaj   +1 more source

Evaluation and associated risk factors for neutropenia with venetoclax and obinutuzumab in the treatment of chronic lymphocytic leukemia

Cancer Reports, 2022
Background The time‐limited combination of venetoclax and obinutuzumab (VenG) was established by the German CLL Study Group in the CLL14 trial for the upfront management of newly diagnosed chronic lymphocytic leukemia (CLL), showing a superior ...
Courtney Samuels, Diana Abbott, Sierra Niemiec, Jennifer Tobin, Angela Falco, Keri Halsema, Manali Kamdar   +6 more
doaj   +1 more source