Results 51 to 60 of about 36,039 (270)

Chemotherapy-induced oral mucositis induced by low dose methotrexate: a case report and literature review

口腔疾病防治, 2023
Objective To investigate the diagnosis and treatment for oral mucositis induced by low-dose methotrexate and to provide a reference for clinicians.
WANG Shanshan , MA Xixing , LI Yanling, LIU Yonghong   +3 more
doaj   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

Prognostic significance of therapy-induced myelosuppression in newly diagnosed glioblastoma

, 2022
BACKGROUND: Myelosuppression is the major toxicity encountered during temozolomide chemoradiotherapy for newly diagnosed glioblastoma. METHODS: We assessed the association of myelosuppression (neutropenia, thrombocytopenia, anemia, lymphopenia) during
Stupp, Roger; https://orcid.org/, Weller, Michael; https://orcid.org/, Oppong, Felix Boakye, Vanlancker, Maureen, Preusser, Matthias; https://orcid.org/, Wick, Wolfgang; https://orcid.org/, Le Rhun, Emilie; https://orcid.org/, Chinot, Olivier L; https://orcid.org/, Nabors, Burt; https://orcid.org/, Gorlia, Thierry   +9 more
core   +2 more sources

NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine Therapy

Medical Sciences
The management of acute lymphoblastic leukemia (ALL), the most common pediatric malignancy, critically relies on thiopurine therapy, such as 6-mercaptopurine (6-MP), during the maintenance phase. However, significant inter-individual response variety and
Isfahan Shah Lubis, Kusnandar Anggadiredja, Aluicia Anita Artarini, Nur Melani Sari, Nur Suryawan, Zulfan Zazuli   +5 more
doaj   +1 more source

Ginsenoside Rg3 for Chemotherapy-Induced Myelosuppression: A Meta-Analysis and Systematic Review

Frontiers in Pharmacology, 2020
Patients with advanced cancer often undergo myelosuppression after receiving chemotherapy. However, severe myelosuppression results in treatment delay, and some can even be life-threatening.
Linlin Pan, Tingting Zhang, Hongfu Cao, Haiyang Sun, Guirong Liu   +4 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Ferulic Acid Promotes Hematopoietic Stem Cell Maintenance in Homeostasis and Injury Through Diminishing Ferroptosis Susceptibility

Antioxidants
Redox balance is essential for maintenance of the hematopoietic stem cell (HSC) pool, which ensures the lifelong hematopoiesis. However, oxidative attack induced by various physiopathological stresses always compromises HSC maintenance, while there ...
Shuzhen Zhang, Yimin Zhang, Jiacheng Le, Kuan Yu, Xinliang Chen, Jun Chen, Mo Chen, Yiding Wu, Yang Xu, Song Wang, Chaonan Liu, Junping Wang, Changhong Du   +12 more
doaj   +1 more source

Linezolid Pharmacokinetics and Its Association with Adverse Drug Reactions in Patients with Drug-Resistant Pulmonary Tuberculosis

Antibiotics, 2023
We evaluated the relationship between the pharmacokinetic parameters of linezolid (LZD) and development of adverse drug reactions (ADRs) in patients with pulmonary drug-resistant tuberculosis.
Chandrasekaran Padmapriyadarsini, Rajesh Solanki, S. M. Jeyakumar, Anuj Bhatnagar, M. Muthuvijaylaksmi, Bharathi Jeyadeepa, Devarajulu Reddy, Prashanth Shah, Rathinam Sridhar, Vikram Vohra, Namrata Kaur Bhui   +10 more
doaj   +1 more source

Atypical cause of prolonged myelosuppression

BMJ Case Reports, 2009
We present the case of a 57-year-old male with poor prognosis (trisomy 21 and monosomy 7) acute myeloid leukaemia (AML) who presented with rigors and fever during cytogenetic remission.Peripheral and central line blood cultures were positive forMycobacterium chelonaeand he commenced empiric treatment with meropenem, amikacin, clarithromycin and ...
Andrew, Smyth, Barry, Macdonagh, Helen, Tuite, Catherine, Fleming, Michael, O'Dwyer   +4 more
openaire   +3 more sources

Alopecia as an Early Clinical Marker for Azathioprine Induced Myelosuppression: A Case Report [PDF]

Azathioprine is a pro-drug and is metabolized by the TPMT enzyme in the body. In South Asians, Azathioprine is known to cause alopecia and bone marrow suppression in patients with TPMT enzyme deficiency.
Ramaswamy, Dr. Subramanian, , Professor, Dutta, Nilanjana, , Final Year MBBS, Babu, Dr. M Suresh, , Professor, Mamadapur, Dr. Mahabaleshwar, , Assistant Professor   +3 more
core   +1 more source