Results 101 to 110 of about 60,444 (298)

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

GWAS study of myelosuppression among NSCLC patients receiving platinum-based combination chemotherapy

Acta Biochimica et Biophysica Sinica
Platinum-based chemotherapy remains the mainstay for non-small cell lung cancer (NSCLC), but it frequently causes dose-limiting myelosuppression, with significant individual variability in susceptibility.
Huang Hanxue, Liu Junyan, Xiao Qi, Mao Chenxue, She Lei, Yu Lulu, Yu Bing, Lei Mengrong, Gao Ying, He Baimei, Pan Pinhua, Li Xi, Yin Jiye, Liu Zhaoqian   +13 more
doaj   +1 more source

The efficacy of recombinant thrombopoietin in murine and nonhuman primate models for radiation-induced myelosuppression and stem cell transplantation [PDF]

, 1998
Radiation-induced pancytopenia proved to be a suitable model system in mice and rhesus monkeys for studying thrombopoietin (TPO) target cell range and efficacy.
Eaton, D.L., Fielder, P.J., Hartong, S.C.C. (Simone), Neelis, K.J. (Karen), Thomas, G.R. (Roger), Wagemaker, G. (Gerard), Wognum, A.W. (Albert)   +6 more
core   +1 more source

Frequency and Severity of Neutropenia Associated with Food and Drug Administration Approved and Compounded Formulations of Lomustine in Dogs with Cancer. [PDF]

, 2015
BackgroundCompounded lomustine is used commonly in veterinary patients. However, the potential variability in these formulations is unknown and concern exists that compounded formulations of drugs may differ in potency from Food and Drug Administration ...
Burton, JH, Knych, HK, Rebhun, RB, Rodriguez, CO, Skorupski, KA, Stanley, SD   +5 more
core   +2 more sources

Modification‐Response Integrated Modules Driven Cyclization‐Dependent Prodrug Self‐Assembly for Reshaping Pro‐Apoptotic Tumor Redox Homeostasis

Exploration, EarlyView.
1. The concept of modification‐response integrated modules was proposed for the first time. 2. Simple, efficient, and feasible drug delivery platforms were developed for systematic regulation of tumor redox microenvironment and reshaping of pro‐apoptotic tumor redox homeostasis.
Yixin Sun, Shiyi Zuo, Wenfeng Zang, Lingxiao Li, Xianbao Shi, Mingzhong Li, Zhonggui He, Bingjun Sun, Jin Sun   +8 more
wiley   +1 more source

Complications of MRSA Treatment: Linezolid-induced Myelosuppression Presenting with Pancytopenia

Western Journal of Emergency Medicine, 2008
Methicillin-resistant Staphylococcus aureus (MRSA) infections have grown to epidemic proportions in the United States. With the development of increasing drug resistance of MRSA to traditional antimicrobials, there has been a search for a more effective ...
Gorchynski, Julie A, Rose, Jeri K
doaj  

Phase I multicenter study of combined high-dose ifosfamide and doxorubicin in the treatment of advanced sarcomas [PDF]

, 2017
Ifosfamide and doxorubicin are the most active agents in the treatment of sarcomas and are characterized by a marked dose-response relationship. The objective of this study was to determine the maximum tolerated dose (MTD) of both agents in combination ...
Bacchi, M., Bressoud, A., Cerny, T., Hermann, R., Leyvraz, S., Lissoni, A., Sessa, C.   +6 more
core  

The efficacy of dietary Spirulina as an adjunct to chemotherapy to improve immune function and reduce myelosuppression in patients with malignant tumors

Translational Cancer Research, 2019
Background Recent studies have demonstrated functional benefits of Spirulina (Arthrospira sp.) in the treatment and prevention of cancer. However, it is unclear if Spirulina can be used to limit the side effects of chemotherapy in patients with malignant
Y. Ge, Y. Kang, Li Dong, Li-Hong Liu, G. An   +4 more
semanticscholar   +1 more source

Adverse Prognostic Impact of Pretransplant Serum Ferritin and Hepcidin on Survival Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation

American Journal of Hematology, EarlyView.
Michelle Pirotte, Marianne Fillet, Laurence Seidel, Evelyne Willems, Sophie Servais, Fréderic Baron, Yves Beguin   +6 more
wiley   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source