Results 11 to 20 of about 60,444 (298)

Burden of chemotherapy‐induced myelosuppression among patients with extensive‐stage small cell lung cancer: A retrospective study from community oncology practices

Cancer Medicine, 2023
Background Myelosuppression is a major dose‐limiting complication of chemotherapy for patients with extensive‐stage small cell lung cancer (ES‐SCLC). The objective was to describe the burden of myelosuppression, treatment patterns, and supportive care ...
Lowell Hart, Augustina Ogbonnaya, Kristen Boykin, Kathryn Deyoung, Ray Bailey, Trevor Heritage, Lorena Lopez‐Gonzalez, Huan Huang, Lucio Gordan   +8 more
doaj   +2 more sources

Reassembling of albumin-bound paclitaxel mitigates myelosuppression and improves its antitumoral efficacy via neutrophil-mediated targeting drug delivery

Drug Delivery, 2022
Albumin-bound paclitaxel (abPTX) has been widely used in cancer treatment. However, dose-related side effects, such as myelosuppression, restrict its clinical application.
Yuxin Chen, Lulu Han, Xiaoyan Qiu, Meng Wang, Zheng Chen, Ying Cai, Yong Xin, Yanfang Lv, Ankang Hu, Dafei Chai, Liantao Li, Huizhong Li, Junnian Zheng, Gang Wang   +13 more
doaj   +2 more sources

TPGS-Modified Long-Circulating Liposomes Loading Ziyuglycoside I for Enhanced Therapy of Myelosuppression

International Journal of Nanomedicine, 2021
Tingting Song,* Hong Wang,* Yue Liu, Rongshan Cai, Dezhi Yang, Yongai Xiong Department of Pharmacy, Zunyi Medical University, Zunyi City, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongai Xiong ...
Song T, Wang H, Liu Y, Cai R, Yang D, Xiong Y   +5 more
doaj   +2 more sources

Ginsenoside Rg3 for Chemotherapy-Induced Myelosuppression: A Meta-Analysis and Systematic Review

Frontiers in Pharmacology, 2020
Patients with advanced cancer often undergo myelosuppression after receiving chemotherapy. However, severe myelosuppression results in treatment delay, and some can even be life-threatening.
Linlin Pan, Tingting Zhang, Hongfu Cao, Haiyang Sun, Guirong Liu   +4 more
doaj   +2 more sources

Jian-Pi-Bu-Xue-Formula Alleviates Cyclophosphamide-Induced Myelosuppression via Up-Regulating NRF2/HO1/NQO1 Signaling

Frontiers in Pharmacology, 2020
Jian-pi-bu-xue-formula (JPBXF), a TCM formula composed of twelve Chinese medicinal herbs, has been used in clinic to ease patients’ state of weakness and fatigue especially after receiving anti-tumor chemotherapy in China.
Qiuju Huang, Qiuju Huang, Lizhi Feng, Lizhi Feng, Hang Li, Hang Li, Liang Zheng, Xiaoxiao Qi, Ying Wang, Qian Feng, Zhongqiu Liu, Xiaohong Liu, Xiaohong Liu, Linlin Lu   +13 more
doaj   +2 more sources

Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression.

ACS Medicinal Chemistry Letters, 2023
Wee1 is a tyrosine kinase that is highly expressed in several cancer types. Wee1 inhibition can lead to suppression of tumor cell proliferation and sensitization of cells to the effects of DNA-damaging agents. AZD1775 is a nonselective Wee1 inhibitor for
Satenig Guler, Maria DiPoto, A. Crespo, R. Caldwell, Benjamin Doerfel, N. Grossmann, Kevin Ho, B. Huck, C. Jones, R. Lan, D. Musil, Justin R. Potnick, Heike Schilke, B. Sherer, S. Simon, C. Sirrenberg, Zhuo Zhang, L. Liu-Bujalski   +17 more
semanticscholar   +1 more source

Selective Bcl-2 inhibition promotes hematopoietic chimerism and allograft tolerance without myelosuppression in nonhuman primates

Science Translational Medicine, 2023
Hematopoietic stem cell transplantation (HSCT) has many potential applications beyond current standard indications, including treatment of autoimmune disease, gene therapy, and transplant tolerance induction.
H. Sasaki, T. Hirose, T. Oura, Ryo Otsuka, I. Rosales, David Ma, G. Lassiter, A. Karadagi, Toshihide Tomosugi, A. Dehnadi, M. Matsunami, Susan Raju Paul, P. Reeves, I. Hanekamp, Samuel Schwartz, R. Colvin, Hang Lee, T. Spitzer, A. Cosimi, P. Cippà, T. Fehr, T. Kawai   +21 more
semanticscholar   +1 more source

Myelosuppression Alleviation and Hematopoietic Regeneration by Tetrahedral‐Framework Nucleic‐Acid Nanostructures Functionalized with Osteogenic Growth Peptide

Advancement of science, 2022
As major complications of chemoradiotherapy, myelosuppression and hematopoietic‐system damage severely affect immunologic function and can delay or even terminate treatment for cancer patients.
Tianxu Zhang, Mi Zhou, Dexuan Xiao, Zhiqiang Liu, Yueying Jiang, Maogeng Feng, Yunfeng Lin, Xiaoxiao Cai   +7 more
semanticscholar   +1 more source

Development of a Machine Learning-Based Prediction Model for Chemotherapy-Induced Myelosuppression in Children with Wilms’ Tumor

Cancers, 2023
Simple Summary Wilms’ tumor is the most common renal malignant tumor in children, and chemotherapy is an indispensable part of the treatment for most Wilms’ tumor patients.
Mu-jie Li, Quan Wang, P. Lu, De‐ying Zhang, Yi Hua, Feng Liu, Xing Liu, Tao Lin, G. Wei, D. He   +9 more
semanticscholar   +1 more source

Ayurveda-based Botanicals as Therapeutic Adjuvants in Paclitaxel-induced Myelosuppression

Frontiers in Pharmacology, 2022
Chemotherapy-induced myelosuppression is one of the major challenges in cancer treatment. Ayurveda-based immunomodulatory botanicals Asparagus racemosus Willd (AR/Shatavari) and Withania somnifera (L.).
Akash Saggam, Prathamesh Kale, S. Shengule, D. Patil, M. Gautam, G. Tillu, K. Joshi, S. Gairola, B. Patwardhan   +8 more
semanticscholar   +1 more source