Results 1 to 10 of about 8,477 (161)

Functional and Structural Investigation of Myenteric Neurons in the Human Colon [PDF]

Gastro Hep Advances
Background and Aims: The enteric nervous system independently controls gastrointestinal function including motility, which is primarily mediated by the myenteric plexus, therefore also playing a crucial role in functional intestinal disorders.
Kristin Elfers, Alina Sophia Sehnert, Alexander Wagner, Ulrich Zwirner, Helena Linge, Ulf Kulik, Daniel Poehnert, Markus Winny, Benjamin Gundert, Heiko Aselmann, Gemma Mazzuoli-Weber   +10 more
doaj   +4 more sources

Intestinal Region-Dependent Alterations of Toll-Like Receptor 4 Expression in Myenteric Neurons of Type 1 Diabetic Rats [PDF]

Biomedicines, 2023
Toll-like receptor 4 (TLR4) can activate pro-inflammatory cascades in the gastrointestinal tract. Our aim was to determine TLR4 expression in myenteric neurons of different gut regions using a type 1 diabetic model.
Nikolett Bódi, Abigél Egyed-Kolumbán, Benita Onhausz, Bence Pál Barta, Afnan AL Doghmi, János Balázs, Zita Szalai, Mária Bagyánszki   +7 more
doaj   +2 more sources

Insulin in Myenteric Neurons: Time-Dependent and Regional Changes in Type 1 Diabetic Rats [PDF]

Cells
Enteric neurons regulating motility display regional damage to diabetes. By inhibiting neuroinflammation, insulin can contribute to neuronal survival, therefore, we aimed to investigate the presence of insulin in myenteric neurons and their nitrergic ...
Abigél Egyed-Kolumbán, Benita Onhausz, Bence Pál Barta, Zita Szalai, Ildikó Huliák, Mónika Kiricsi, Mária Bagyánszki, Nikolett Bódi   +7 more
doaj   +2 more sources

Intestinal Region-Dependent Impact of NFκB-Nrf Crosstalk in Myenteric Neurons and Adjacent Muscle Cells in Type 1 Diabetic Rats [PDF]

Biomedicines
Background/Objectives: Type 1 diabetes affects cytokines as potential inducers of NFκB signalling involved in inflammation and neuronal survival. Our goal was to assess the expression of NFκB p65 and its negative regulator, Nrf2, in myenteric neurons and
Bence Pál Barta, Benita Onhausz, Abigél Egyed-Kolumbán, Afnan AL Doghmi, János Balázs, Zita Szalai, Ágnes Ferencz, Edit Hermesz, Mária Bagyánszki, Nikolett Bódi   +9 more
doaj   +2 more sources

Neurochemical characterization of myenteric neurons in the juvenile gilthead sea bream (Sparus aurata) intestine. [PDF]

PLoS ONE, 2018
We evaluated the chemical coding of the myenteric plexus in the proximal and distal intestine of gilthead sea bream (Sparus aurata), which represents one of the most farmed fish in the Mediterranean area. The presence of nitric oxide (NO), acetylcholine (
Chiara Ceccotti, Cristina Giaroni, Michela Bistoletti, Manuela Viola, Francesca Crema, Genciana Terova   +5 more
doaj   +2 more sources

Activity of protease-activated receptors in primary cultured human myenteric neurons

Frontiers in Neuroscience, 2012
Activity of the four known protease-activated receptors (PARs) has been well studied in rodent enteric nervous system and results in animal models established an important role for neuronal PAR2.
Eva Maria Kugler, Gemma eMazzuoli, Ihsan Ekin Demir, Gueralp Onur Ceyhan, Florian eZeller, Michael eSchemann   +5 more
doaj   +3 more sources

Mechanical stress activates neurites and somata of myenteric neurons [PDF]

Frontiers in Cellular Neuroscience, 2015
The particular location of myenteric neurons, sandwiched between the 2 muscle layers of the gut, implies that their somata and neurites undergo mechanical stress during gastrointestinal motility.
Eva Maria Kugler, Klaus eMichel, Florian eZeller, Ihsan Ekin Demir, Güralp Onur Ceyhan, Michael eSchemann, Gemma eMazzuoli-Weber   +6 more
doaj   +2 more sources

Pathophysiological Roles of Neuro-Immune Interactions between Enteric Neurons and Mucosal Mast Cells in the Gut of Food Allergy Mice

Cells, 2021
Recently, the involvement of the nervous system in the pathology of allergic diseases has attracted increasing interest. However, the precise pathophysiological role of enteric neurons in food allergies has not been elucidated.
Tomoe Yashiro, Hanako Ogata, Syed Faisal Zaidi, Jaemin Lee, Shusaku Hayashi, Takeshi Yamamoto, Makoto Kadowaki   +6 more
doaj   +1 more source

Immediate Insulin Treatment Prevents Diabetes-Induced Gut Region-Specific Increase in the Number of Myenteric Serotonergic Neurons

Applied Sciences, 2021
To evaluate the effects of hyperglycemia and insulin treatment on the proportion of serotonin-immunoreactive (5-HT-IR) myenteric neurons, samples were taken from the duodenum, ileum, and colon of diabetic, insulin-treated diabetic, and control rats 10 ...
Diána Mezei, Nikolett Bódi, Zita Szalai, Zsuzsanna Márton, János Balázs, Mária Bagyánszki   +5 more
doaj   +1 more source

L-Cysteine Alleviates Myenteric Neuron Injury Induced by Intestinal Ischemia/Reperfusion via Inhibitin the Macrophage NLRP3-IL-1β Pathway

Frontiers in Pharmacology, 2022
Ischemia/reperfusion injury is a common pathophysiological process in the clinic. It causes various injuries, multiple organ dysfunction, and even death.
Yifei Gao, Haojie Zhang, Yujin Wang, Ting Han, Jing Jin, Jingxin Li, Yan Tang, Chuanyong Liu, Chuanyong Liu   +8 more
doaj   +1 more source