Results 51 to 60 of about 8,496 (180)

Computational simulations and Ca2+ imaging reveal that slow synaptic depolarizations (slow EPSPs) inhibit fast EPSP evoked action potentials for most of their time course in enteric neurons.

PLoS Computational Biology, 2022
Transmission between neurons in the extensive enteric neural networks of the gut involves synaptic potentials with vastly different time courses and underlying conductances.
Parvin Zarei Eskikand, Katerina Koussoulas, Rachel M Gwynne, Joel C Bornstein   +3 more
doaj   +1 more source

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study

Journal of Anatomy, EarlyView.
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli, Georgia Colleluori, Jessica Perugini, Edoardo Scopini, Ilenia Severi, Gaia Grandin, Antonio Giordano   +6 more
wiley   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Effects of sucrose-rich diets and pterostilbene on oxidative status and intrinsic innervation of the jejunum in rats

Acta Scientiarum: Biological Sciences
Obesity is a chronic disease related to gastrointestinal disorders. Pterostilbene has already demonstrated beneficial activity. This study aimed to evaluate the effects of a sucrose-rich diet and pterostilbene on oxidative status, intestinal wall, and ...
Joice Moraes Menezes, Ana Paula da Silva Barbosa, Wesley Ladeira Caputo, Carlos Vinícius Dalto da Rosa, Fábio Rodrigues Ferreira Seiva, João Paulo Ferreira Schoffen   +5 more
doaj   +1 more source

Novel volume‐electron microscopic ultrastructural analysis of gastrointestinal excitability associated with calcium–activated chloride channels

The Journal of Physiology, EarlyView.
Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley   +1 more source

Glycine activates myenteric neurones in adult guinea‐pigs

The Journal of Physiology, 2001
1. We studied the effects of glycine on myenteric neurones and muscle activity in the colon and stomach of adult guinea-pigs. 2. Intracellular recordings revealed that myenteric neurones responded to local microejection of glycine (1 mM) with a fast, transient membrane potential depolarisation (57 % of 191 colonic neurones and 26 % of 50 gastric ...
M, Neunlist, K, Michel, D, Reiche, G, Dobreva, K, Huber, M, Schemann   +5 more
openaire   +3 more sources

Pan‐TRK expression and NTRK gene aberrations in meningiomas: association with tumor grade and proliferative activity

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Tropomyosin receptor kinase (TRK) fusions are actionable oncogenic drivers, and pan‐TRK immunohistochemistry (IHC) serves as a reliable screening tool for NTRK gene aberrations. However, the expression profile and clinical significance of pan‐TRK in meningiomas remain unclear.
Yinan Zhu, Mingfang Sun, Wanchen Lu, Ziyue Wang, Haiyan Xi, Yan Song, Hongtao Xu, Xuyong Lin   +7 more
wiley   +1 more source

Effects of L-glutamine supplementation on the myenteric neurons from the duodenum and cecum of diabetic rats

Arquivos de Gastroenterologia, 2011
CONTEXT: Peripheral neuropathy is one of the chronic complications of diabetes mellitus and is directly related to gastrointestinal consequences of the disease.
Jacqueline Nelisis Zanoni, Eleandro Aparecido Tronchini, Sheila Alves Moure, Ivan Domicio da Silva Souza   +3 more
doaj   +1 more source

Interplay of the ENS and Microbiota With Murine Gut Epithelium‐Derived Organoids in Aging

Aging Cell, Volume 25, Issue 7, July 2026.
A gut organoid model was developed to study the impact of age‐related changes of the enteric nervous system (ENS) and microbiome on the integrity and trophic capacity of the intestinal epithelial barrier. Organoids reflected in vivo aging features, including altered epithelial integrity and changes in acetylcholine‐related enzyme activity.
Tinh Thi Nguyen, Dennis Schapelhouman, Katharina Fischer, Jia‐Xuan Chen, Mario Dejung, Fridolin Kielisch, Julia Varga, Johannes Piepgras, Matthew Ahn, Oliver Tüscher, Peter Baumann, Sandra Schick, Kristina Endres   +12 more
wiley   +1 more source

Stroke Alters the Function of Enteric Neurons to Impair Smooth Muscle Relaxation and Dysregulates Gut Transit

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Gut dysmotility is common after ischemic stroke, but the mechanism underlying this response is unknown. Under homeostasis, gut motility is regulated by the neurons of the enteric nervous system that control contractile/relaxation activity of ...
Kathryn Prame Kumar, Jenny L. Wilson, Huynh Nguyen, Liam D. McKay, Shu Wen Wen, Tara Sepehrizadeh, Michael de Veer, Pradeep Rajasekhar, Simona E. Carbone, Michael J. Hickey, Daniel P. Poole, Connie H. Y. Wong   +11 more
doaj   +1 more source