Results 61 to 70 of about 8,496 (180)

Neurally Released GABA Acts via GABAC Receptors to Modulate Ca2+ Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum

Frontiers in Physiology, 2018
γ-Aminobutyric Acid (GABA) and its receptors, GABAA,B,C, are expressed in several locations along the gastrointestinal tract. Nevertheless, a role for GABA in enteric synaptic transmission remains elusive.
Katerina Koussoulas, Mathusi Swaminathan, Candice Fung, Joel C. Bornstein, Jaime P. P. Foong   +4 more
doaj   +1 more source

CLONIDINE ACTIVATES MEMBRANE POTASSIUM CONDUCTANCE IN MYENTERIC NEURONES [PDF]

British Journal of Pharmacology, 1981
Intracellular recordings were made from neurones in the myenteric plexus of the ileum removed from guinea‐pigs. The effects of clonidine and adrenaline on membrane potential and resistance were observedClonidine (100 pM‐30 nM) caused a concentration‐dependent membrane hyperpolarization associated with a fall in neurone input resistanceThe amplitude of ...
K, Morita, R A, North
openaire   +2 more sources

Development and functional adaptation of intestinal macrophages across the lifespan

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This article discusses intestinal macrophage development, including the influence of developmental origins and life stages; ontogeny and functional heterogeneity; preclinical and clinical evidence. Abstract Macrophages of the gastrointestinal system are central regulators of gut development, homeostasis and disease, yet their origin, functional ...
Baha Mustafa, Elisa L Hill‐Yardin, Sarah J Spencer   +2 more
wiley   +1 more source

When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions

Movement Disorders, Volume 41, Issue 6, Page 1337-1348, June 2026.
Abstract Although Parkinson's disease (PD) is classically defined by its motor features, non‐motor symptoms exert a substantial and often under‐recognized influence on disease trajectory. Among these, weight loss has long been observed in PD and other neurodegenerative disorders, yet the mechanisms remain incompletely understood.
Ellie D. Gabriel, Robert S. Eisinger, Joyce M. Lee, Sarah Hamimi, Hope Kim, Susanna D. Howard, Casey H. Halpern   +6 more
wiley   +1 more source

Morphometry of myenteric neurons in stomach.

Nepal Medical College journal : NMCJ, 2007
The wall of the gastrointestinal tract presents extensive plexuses of nerve fibres and neuronal cell bodies responsible for the modulation of the rhythmic gastrointestinal peristaltic activities, among other functions. One of the most developed ganglionated plexuses of the gastrointestinal tract is the Myenteric plexus located between the inner ...
Narbada, Saini, Madhur, Gupta
openaire   +1 more source

Computational Quantification of Peristalsis in Preclinical Mouse Models Using Smartphone Videography

Neurogastroenterology &Motility, Volume 38, Issue 6, June 2026.
A new computational method and analytical pipeline for quantifying gut peristalsis in live mouse models that involves taking a video using a smartphone camera and then processing the videographic data using our custom analytical pipeline to quantify gastrointestinal motility.
Joseph C. Schindler, Gargi Vijayan Pillai, Thomas M. Raffay, Satish E. Viswanath, Puneet Seth   +4 more
wiley   +1 more source

Increased proportion of nitric oxide synthase immunoreactive neurons in rat ileal myenteric ganglia after severe acute pancreatitis

BMC Gastroenterology, 2011
Background Severe acute pancreatitis (SAP) remains a potentially life-threatening disease. Gastrointestinal motility disturbance such as intestinal ileus is seen in every case. By now, the mechanisms of pancreatitis-induced ileus are largely unknown. The
Lin Zhong, Liu Ying, Zheng Qinghua, Hu Qinghua   +3 more
doaj   +1 more source

The calcium current in a myenteric neurone of the guinea‐pig ileum.

The Journal of Physiology, 1985
The active and passive electrical properties of the after‐hyperpolarizing (AH) cell of the guinea‐pig myenteric plexus were analysed using a single‐electrode voltage or current clamp. Action potentials were compared under normal conditions, in the presence of tetrodotoxin (TTX) and in the presence of both TTX and tetraethylammonium chloride (TEA ...
G D, Hirst, S M, Johnson, D F, van Helden   +2 more
openaire   +3 more sources

Simulations of Myenteric Neuron Dynamics in Response to Mechanical Stretch

Computational Intelligence and Neuroscience, 2020
Background. Intestinal sensitivity to mechanical stimuli has been studied intensively in visceral pain studies. The ability to sense different stimuli in the gut and translate these to physiological outcomes relies on the mechanosensory and transductive capacity of intrinsic intestinal nerves.
Donghua Liao, Jingbo Zhao, Hans Gregersen   +2 more
openaire   +3 more sources

Abnormal Enteric Nervous System Organization and Gastrointestinal Motility in Mice With Valproic Acid‐Induced Neural Tube Defects

Neurogastroenterology &Motility, Volume 38, Issue 6, June 2026.
Gastrointestinal tracts from fetuses with a valproic acid‐induced neural tube defect contain blood. Structurally, the enteric neuronal stripes are thinner with a narrower interstripe distance, leading to an increased number of stripes. Functionally, gastrointestinal motility is abnormal, with increased contraction frequency and increased length of ...
Gabrielle R. Barsh, Kelbi Banducci, Julia A. Kaltschmidt   +2 more
wiley   +1 more source