Results 71 to 80 of about 18,192 (271)

Slow Transit Constipation: Pathophysiological Perspectives and Management Updates

Journal of Digestive Diseases, EarlyView.
Slow transit constipation (STC) is a complex neuromuscular disorder driven by interstitial cells of Cajal (ICCs) loss and enteric neuropathy. Diagnosis relies on objective transit testing while excluding pelvic floor dysfunction. Management follows a stepwise, phenotype‐driven approach, progressing from conventional laxatives to emerging targeted ...
Athanasios Syllaios, Stavros P. Papadakos, Alexandros Ioannou, Maximos Frountzas, Dimosthenis Michelakis, Dimitrios Patsouras, Spyridon Dritsas, Manousos‐Georgios Pramateftakis, Dimitrios Schizas   +8 more
wiley   +1 more source

Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system [PDF]

, 2014
UCHL1 (ubiquitin carboxyterminal hydrolase 1) is a deubiquitinating enzyme that is particularly abundant in neurons. From studies of a spontaneous mutation arising in a mouse line it is clear that loss of function of UCHL1 generates profound degenerative
Douglas A. Gray, John Woulfe, Josée Coulombe, M. Jill Saffrey, Madison T. Gray, Matthew Y. Tang, Mei Zhang, Prasanna Gamage   +7 more
core   +1 more source

Comparison of wholemount dissection methods for neuronal subtype marker expression in the mouse myenteric plexus [PDF]

, 2023
Julieta Gomez‐Frittelli, Ryan Hamnett, Julia A. Kaltschmidt   +2 more
openalex   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm, Neha Gupta, Alexandru Mircea, Caoimhin S. Griffin   +3 more
wiley   +1 more source

Beta-3 Adrenoceptor Agonism Protects the Enteric Nervous Tissue Against Hyperoxia-Induced Damage

Cells
The beta-3 adrenergic receptor (β3-AR), whose expression is modulated by oxygen levels, was found to play a key role in organ maturation, and its agonism was reported to mitigate hyperoxia-induced large bowel damage by preventing organ hypoplasia ...
Patrizia Nardini, Luca Filippi, Virginia Zizi, Marta Molino, Camilla Fazi, Matteo Chivetti, Alessandro Pini   +6 more
doaj   +1 more source

Feed-Forward Inhibition of CD73 and Upregulation of Adenosine Deaminase Contribute to the Loss of Adenosine Neuromodulation in Postinflammatory Ileitis

Mediators of Inflammation, 2014
Purinergic signalling is remarkably plastic during gastrointestinal inflammation. Thus, selective drugs targeting the “purinome” may be helpful for inflammatory gastrointestinal diseases. The myenteric neuromuscular transmission of healthy individuals is
Cátia Vieira, Maria Teresa Magalhães-Cardoso, Fátima Ferreirinha, Isabel Silva, Ana Sofia Dias, Julie Pelletier, Jean Sévigny, Paulo Correia-de-Sá   +7 more
doaj   +1 more source

Morphology and Chemical Coding of Rat Duodenal Enteric Neurons following Prenatal Exposure to Fumonisins

Animals, 2022
Fumonisins (FBs), including fumonisin B1 and B2 produced by the fungus Fusarium verticillioides, are widespread mycotoxins contaminating crop plants as well as processed food.
Katarzyna Kras, Halyna Rudyk, Siemowit Muszyński, Ewa Tomaszewska, Piotr Dobrowolski, Volodymyr Kushnir, Viktor Muzyka, Oksana Brezvyn, Marcin B. Arciszewski, Ihor Kotsyumbas   +9 more
doaj   +1 more source

Role of neuronal and inducible nitric oxide synthases in the guinea pig ileum myenteric plexus during in vitro ischemia and reperfusion [PDF]

, 2013
Background Intestinal ischemia and reperfusion (I/R) injury leads to abnormalities in motility, namely delay of transit, caused by damage to myenteric neurons. Alterations of the nitrergic transmission may occur in these conditions.
Bartolini, B., Carpanese, E., Crema, F., Frigo, G. M., Giaroni, Cristina, Lecchini, Sergio, Marchet, S., Moro, E., Oldrini, R., Prandoni, V., Vigetti, Davide   +10 more
core   +1 more source

Enhanced Visualization of the Distal Myotomy Endpoint during Peroral Endoscopic Myotomy Using Indocyanine Green With Infrared Imaging

DEN Open, Volume 6, Issue 1, April 2026.
Indocyanine green with infrared imaging (ICG‐IRI) provides real‐time fluorescence visualization of the distal myotomy endpoint during peroral endoscopic myotomy (POEM). In this study of 39 patients, ICG‐IRI achieved a 94.9% success rate in fluorescence detection and significantly improved esophageal relaxation and symptoms.
Yuichiro Ikebuchi, Takuki Sakaguchi, Moe Eizawa, Tsuyoshi Mikamo, Kazuhiro Takemoto, Yuki Fujii, Ryohei Ogihara, Yu Kamitani, Mirai Edano, Hidehito Kinoshita, Hiroki Kurumi, Takashi Hasegawa, Koichiro Kawaguchi, Kazuo Yashima, Hajime Isomoto   +14 more
wiley   +1 more source

Dangerous Liaison: Helicobacter pylori, Ganglionitis, and Myenteric Gastric Neurons: A Histopathological Study

Analytical Cellular Pathology, 2019
Chronic inflammation induced by Helicobacter pylori (H. pylori) infection plays a major role in development of gastric cancer. However, recent findings suggested that progression of inflammation and neoplastic transformation in H.
Liana Sticlaru, Florica Stăniceanu, Mirela Cioplea, Luciana Nichita, Alexandra Bastian, Gianina Micu, Cristiana Popp   +6 more
doaj   +1 more source