Results 101 to 110 of about 18,051 (238)

Novel MYH7 Variant in the Neonate of a Mother with Gestational Diabetes Mellitus Showing Left Ventricular Hypertrophy and Noncompaction

Genes
Background: Left ventricular hypertrophy (LVH) is a well-recognized cardiac dysfunction in infants of mothers with gestational diabetes mellitus (GDM).
Sayaka W Ozawa, Satomi Inomata, Yukiko Hata, S. Takarada, M. Okabe, H. Nakaoka, K. Ibuki, Naoki Nishida, F. Ichida, K. Hirono   +9 more
semanticscholar   +1 more source

The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients

British Journal of Pharmacology, EarlyView.
Background and Purpose Novel heart failure (HF) pharmacotherapies, including angiotensin receptor‐neprilysin inhibitor (ARNI) and sodium‐glucose cotransporter 2 inhibitors (SGLT2is), may confer cardiovascular benefits by attenuating myocardial fibrosis. However, direct evidence from human failing myocardial samples is limited.
Dávid Nagy, Tamás Radovits, Tímea Bálint, Zoltán Horváth, Petra Kocsis‐Balogh, Ákos Gergely Tóth, Attila Oláh, Alex Ali Sayour, Bálint András Barta, Béla Merkely, Mihály Ruppert   +10 more
wiley   +1 more source

Data mining on identifying diagnosis and prognosis biomarkers in head and neck squamous carcinoma

Scientific Reports, 2023
Head and neck squamous carcinoma (HNSC) induces high cancer-related death worldwide. The biomarker screening on diagnosis and prognosis is of great importance.
Guoyuan Ju, Zhangyu Yao, Yanbin Zhao, Xiaotong Zhao, Fangzhou Liu   +4 more
doaj   +1 more source

Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. [PDF]

, 2019
The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population.
Alex, Linda, Baines, Christopher P, Domeier, Timothy L, Edwards, Jenna C, Emter, Craig A, Ferreira-Nichols, Stephanie C, Ford, David A, Gao, Chen, Ivey, Jan R, Jones, John L, Jurrissen, Thomas J, Klutho, Paula J, Krenz, Maike, McDonald, Kerry S, Olver, T Dylan, Padilla, Jaume, Rau, Christoph, Rector, R Scott, Solaro, R John, Thorne, Pamela K, Veteto, Adam B, Wang, Yibin, Warren, Chad M   +22 more
core  

Transcriptomic Remodeling of Pulmonary Vein Sleeves Suggests a Role in Atrial Arrhythmogenesis in Thoroughbred Horses

Annals of the New York Academy of Sciences, EarlyView.
Myocardial sleeves of the pulmonary veins in racehorses with paroxysmal atrial fibrillation exhibit upregulated pathways associated with tissue structure remodeling. Pathways related to the extracellular matrix and cellular components differ significantly from those in healthy horses.
Magdalena Arevalo‐Turrubiarte, Charlotte E. Edling, Carla Moller‐Levet, Bronte Forbes, Victoria Kemp, Joe Weir, Celia Marr, Rebecca Lewis, Kamalan Jeevaratnam   +8 more
wiley   +1 more source

A de novo germline mutation in MYH7 causes a progressive dominant myopathy in pigs

BMC Genetics, 2012
Background About 9% of the offspring of a clinically healthy Piétrain boar named ‘Campus’ showed a progressive postural tremor called Campus syndrome (CPS).
Murgiano Leonardo, Tammen Imke, Harlizius Barbara, Drögemüller Cord   +3 more
doaj   +1 more source

Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases [PDF]

, 2019
Heart failure (HF) is a highly complex disorder and a major end-point of cardiovascular diseases (CVD). The pathogenesis of HF is mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell ...
Kasi Ganeshan, T., Kasi Ganeshan, T.
core  

Next-generation sequencing-based genome diagnostics across clinical genetics centers: Implementation choices and their effects [PDF]

, 2015
Implementation of next-generation DNA sequencing (NGS) technology into routine diagnostic genome care requires strategic choices. Instead of theoretical discussions on the consequences of such choices, we compared NGS-based diagnostic practices in eight ...
Butler, D. (Derek), Claes, G. (Godelieve), Costessi, A. (Adalberto), Cuppen, E. (Edwin), De Koning, B. (Bart), Dorlijn, W. (Wim), Dunnen, J.T. (Johan) den, Elferink, M.G. (Martin), Halley, D.J.J. (Dicky), Hennekam, R.C.M. (Raoul), IJcken, W.F.J. (Wilfred) van, Ijntema, H. (Helger), Johansson, L.F. (Lennart F.), Jongbloed, J.D.H. (Jan), Kamps, R. (Rick), Kockx, C. (Christel), Kraaijeveld, K. (Ken), Kranendonk, E. (Elcke), Kriek, N. (Nadia), Lekanne Dit Deprez, R.H., Ligt, J. (Joep) de, Lunstroo, H. (Hans), Mannens, M.M.A.M. (Marcel), Mook, O. (Olaf), Nelen, M.R. (Marcel), Nijman, I.J. (Isaac ), Ploem, C. (Corrette), Rijnen, M. (Marco), Santen, G.W.E. (Gijs), Saris, J.J. (Jasper), Sinke, R.J. (Richard J), Sistermans, E. (Erik), Slegtenhorst, M.A. (Marjon) van, Sleutels, F. (Frank), Stoep, N. (Nienke) van der, Tienhoven, M. (Marianne) van, Van Den Hout, M.C.G.N. (Mirjam C.G.N.), Van Eyndhoven, W. (Winfried), Van Hove, S. (Steven), Veltman, J.A. (Joris), Vermaat, M. (Martijn), Vogel, M.J. (Maartje), Vrijenhoek, T. (T.), Waisfisz, Q. (Quinten), Weiss, J.M. (Janneke), Wijngaard, A. (Arthur) van den, Workum, W. (W) van, Zwaag, B. (Bert) van der   +47 more
core   +1 more source

Establishment of a mouse model for ischaemic heart failure induced by coronary microembolization via left ventricular oil injection

Experimental Physiology, EarlyView.
Abstract Over the past three decades, there has been a steady increase in clinical attention to ischaemic heart failure caused by coronary microembolization. Nonetheless, a suitable mouse model for studying this condition remains limited. In the present study, we developed a mouse model of coronary microembolization‐induced ischaemic heart failure by ...
Lang Pei, Yusheng Hong, Qiuyue Wu, Jianyi Lv, Changlong Li, Xueyun Huo, Xin Liu, Di Zhang, Meng Guo, Zhenwen Chen, Xiaoyan Du   +10 more
wiley   +1 more source

Essential role of TEA domain transcription factors in the negative regulation of the MYH 7 gene by thyroid hormone and its receptors.

PLoS ONE, 2014
MYH7 (also referred to as cardiac myosin heavy chain β) gene expression is known to be repressed by thyroid hormone (T3). However, the molecular mechanism by which T3 inhibits the transcription of its target genes (negative regulation) remains to be ...
Hiroyuki Iwaki, Shigekazu Sasaki, Akio Matsushita, Kenji Ohba, Hideyuki Matsunaga, Hiroko Misawa, Yutaka Oki, Keiko Ishizuka, Hirotoshi Nakamura, Takafumi Suda   +9 more
doaj   +1 more source