Results 91 to 100 of about 13,305 (193)

MYH7, c.2011C>T, is responsible for congenital scoliosis in a Chinese family

Biochemistry and Biophysics Reports
Neuromuscular scoliosis can be caused by muscular or nervous system dysfunction resulting from genetic variants. Variation in MYH7 may cause hypertrophic or dilated cardiomyopathy, skeletal myopathies, or a combination of both; however, scoliosis has ...
Ping Wei, Fulong Xu, Caixia Xian, Yanhan Liu, Yibo Xu, Ting Zhang, Weizhe Shi, Sihong Huang, Xiang Zhou, Mingwei Zhu, Hongwen Xu   +10 more
doaj   +1 more source

Essential role of TEA domain transcription factors in the negative regulation of the MYH 7 gene by thyroid hormone and its receptors.

PLoS ONE, 2014
MYH7 (also referred to as cardiac myosin heavy chain β) gene expression is known to be repressed by thyroid hormone (T3). However, the molecular mechanism by which T3 inhibits the transcription of its target genes (negative regulation) remains to be ...
Hiroyuki Iwaki, Shigekazu Sasaki, Akio Matsushita, Kenji Ohba, Hideyuki Matsunaga, Hiroko Misawa, Yutaka Oki, Keiko Ishizuka, Hirotoshi Nakamura, Takafumi Suda   +9 more
doaj   +1 more source

Dietary Polyphenols as Regulators of Protein Deposition and Muscle Health: Mechanisms, Interactions, and Functional Applications

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Dietary polyphenols contribute to the regulation of protein deposition and muscle health through multiple interconnected mechanisms. They promote protein synthesis and myogenic differentiation mainly by modulating the PI3K/AKT/mTOR signaling pathway and myogenic regulatory factors, while suppressing excessive protein degradation through regulation of ...
Chen Liu, Mengyi Ren, Xin Lai, Ke Gu, Liqiang Tan, Aimin Wu, Daiwen Chen   +6 more
wiley   +1 more source

Ets2 Is an Activity‐Dependent Transcriptional Regulator of a Fast‐Twitch Muscle Program

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Ets2 is a transcription factor rapidly (24 h) upregulated in skeletal muscle by fast 150 Hz, but not slow 20 Hz, stimulation patterns. Ets2 selectively translocates to nuclei of slow soleus muscle when stimulated by fast‐patterned, but not slow‐patterned, activity. Ets2 binds to a consensus DNA sequence in the troponin I fast intronic enhancer (TnIFIRE)
Zaheer A. Rana, Jo C. Bruusgaard, Jens R. Wendland, Ivan Winje, Ingrid M. Egner, Irina Karavanova, Einar Eftestøl, Detlef Vullhorst, Kristian Gundersen, Andres Buonanno   +9 more
wiley   +1 more source

The Maternal Blood Transcriptome Reflects Molecular Signatures Associated With Large Offspring Syndrome and Other Adverse Pregnancy Outcomes in Cattle

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Blood samples from pregnant heifers carrying in vitro‐produced embryos were analyzed for RNA‐sequencing to test whether maternal blood transcriptome could be predictive of large offspring syndrome, stillbirth, and abortion compared with controls.
Tatiane S. Maia, Maria B. Rabaglino, Rebecca Krisher, Paula Rodriguez‐Villamil, Jeniffer Pamela J. Laguna, Jeniffer F. Escoto, Yanping Zhang, Abigail J. Sproull, Peter J. Hansen   +8 more
wiley   +1 more source

The contribution of mutations in MYH7 to the onset of cardiomyopathy [PDF]

Netherlands Heart Journal, 2017
Bollen, I. A.E., van der Velden, J.
openaire   +3 more sources

Clinical Features and Outcomes of Pediatric MYH7 ‐Related Dilated Cardiomyopathy

Journal of the American Heart Association
Background Although genetic variants in MYH7 are the most frequent cause of pediatric genetic dilated cardiomyopathy (DCM), there are no studies available describing this entity.
Fernando de Frutos, Juan Pablo Ochoa, Gregory Webster, Mark Jansen, Paloma Remior, Torsten B. Rasmussen, Maria Sabater‐Molina, Roberto Barriales‐Villa, Francesca Girolami, Sergi Cesar, M. Eugenia Fuentes‐Cañamero, Reyes Alvarez García‐Rovés, Karim Wahbi, Javier Limeres, Milos Kubanek, Martijn G. Slieker, Georgia Sarquella‐Brugada, Dominic J. Abrams, Dennis Dooijes, Fernando Domínguez, Pablo Garcia‐Pavia   +20 more
openaire   +7 more sources

Sarcomeric hypertrophic cardiomyopathy: Genetic profile in a Portuguese population

Revista Portuguesa de Cardiologia, 2012
Background: Sarcomeric hypertrophic cardiomyopathy has heterogeneous phenotypic expressions, of which sudden cardiac death is the most feared. A genetic diagnosis is essential to identify subjects at risk in each family.
Dulce Brito, Gabriel Miltenberger-Miltenyi, Sónia Vale Pereira, Doroteia Silva, António Nunes Diogo, Hugo Madeira   +5 more
doaj   +1 more source

Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra‐Nuclear Signaling to Modulate Human Granulosa Cell Growth

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Working model of ERβ isoform signaling in human granulosa cells. Upon E2 binding, ERβ1 activates ERE‐dependent transcription and represses AP‐1 activity through Jun/Fos interactions. In contrast, ERβ2, ERβ4, and ERβ5 lack E2 binding and ERE activity but promote AP‐1‐dependent transcription and counteract ERβ1 repression, including after phosphorylation
Clémentine Marie, Inza‐Noor Baskaran, Raphaël Corre, Anne Mayeur, Michaël Grynberg, Guillaume Chevreux, David L'Hôte, Joëlle Cohen‐Tannoudji, Stéphanie Chauvin   +8 more
wiley   +1 more source

Perinatal death in pig models of hypertrophic cardiomyopathy carrying sarcomere pathogenic variants

Journal of Molecular and Cellular Cardiology Plus
Hypertrophic cardiomyopathy (HCM) is an autosomal-dominant disease caused by genetic variants in sarcomeric proteins, particularly in myosin binding protein C3 (MYBPC3) and myosin heavy chain 7 (MYH7).
Tatiana Flisikowska, Björn Petersen, Giulia Mearini, Daniela Huber, Mayuko Kurome, Melanie Stoff, Saskia Schlossarek, Andrea Lucas-Hahn, Eckhard Wolf, Judith Montag, Angelika Schnieke, Lucie Carrier   +11 more
doaj   +1 more source