Results 71 to 80 of about 13,305 (193)

Butein Attenuates Cardiac Hypertrophy by Restoring Redox–Mitochondrial Homeostasis Through Nrf2–Sirt3 Signaling

Phytotherapy Research, EarlyView.
Butein attenuates pathological cardiac hypertrophy by activating Nrf2–Sirt3 signaling, restoring mitochondrial function and redox homeostasis. ABSTRACT Butein (3,4,2′,4′‐tetrahydroxychalcone) is a bioactive chalcone with antioxidant, anti‐inflammatory, and cytoprotective properties.
Tsendsuren Tungalag, Dong Kwon Yang
wiley   +1 more source

Identification of enhancers responsible for the coordinated expression of myosin heavy chain isoforms in skeletal muscle

BMC Genomics, 2022
Background Skeletal muscles consist of fibers of differing contractility and metabolic properties, which are primarily determined by the content of myosin heavy chain (MYH) isoforms (MYH7, MYH2, MYH1, and MYH4).
Keren Long, Duo Su, Xiaokai Li, Hengkuan Li, Sha Zeng, Yu Zhang, Zhining Zhong, Yu Lin, Xuemin Li, Lu Lu, Long Jin, Jideng Ma, Qianzi Tang, Mingzhou Li   +13 more
doaj   +1 more source

Cardiomyocyte Membrane‐Camouflaged Spinach Nano‐Thylakoids Enhance Myocardial Energy Metabolism and Ameliorate Heart Failure

Small, EarlyView.
Schematic illustration of the construction of MM‐NTU, its cardiac‐targeting behavior, and its light‐activated therapeutic mechanism. Thylakoids isolated from spinach chloroplasts were processed into nano‐thylakoid units (NTU) and further camouflaged with cardiomyocyte membranes to generate MM‐NTU.
Haohui Fan, Bei Song, Chengyun Liu, Peiyu Zhong, Quan Zhou, Xiaofang Zhao, Guangyu Gao, Xinyue Zhang, Xueke Guang, Tianci Yao, Ting Liu, Hao Zhang, Xinqi Diao, Weilin Lu   +13 more
wiley   +1 more source

Clinical and imaging hallmarks of the MYH7 ‐related myopathy with severe axial involvement

, 2018
INTRODUCTION: MYH7 gene mutations are related to a heterogeneous group of skeletal and cardiac myopathies. METHODS: We evaluated clinical and muscle MRI changes in patients with mutations in the rod domain of MYH7, including 1 with mosaicism and 3 with ...
Carlier, Robert, Yann PéRéon, Adele D'amico, Osório Abath Neto, Pereon, Yann, Cristiane Araújo Martins Moreno, Doris Lechner, Moreno, Cristiane, Enrico Bertini, Edoardo Malfatti, Neto, Osório, Felter, Adrien, Claudia Castiglioni, Rodillo, Elliena, Quijano-Roy, Susana, Fabiana Fattori, Catteruccia, Michela, Boland, Anne, júlio Brandão Guimarães, Anne Boland, Bertini, Enrico, Jean‐François Deleuze, Adrien Felter, Reed, Umbertina, Mesrob, Lilia, Romero, Norma, Acary Souza Bulle Oliveira, Edmar Zanoteli, Robert Y Carlier, Bonnemann, Carsten, Guimaraes, Julio, Deleuze, Jean-François, Malfatti, Edoardo, Ivana Dabaj, Gomez-Andres, David, Norma Romero, d'Amico, Adele, Jocelyn Laporte, Michela Catteruccia, Umbertina Conti Reed, Fattori, Fabiana, Zanoteli, Edmar, Dabaj, Ivana, Oliveira, Acary, Eliana Rodillo, Carsten Bonnemann, Susana Quijano‐Roy, David Gómez‐Andrés, Laporte, Jocelyn, Lilia Mesrob, Castiglioni, Claudia, Lechner, Doris   +51 more
core   +1 more source

Polymorphism on Myh7 and Mybpc3 Genes between B6 and D2 Strains.

, 2015
Polymorphism on Myh7 and Mybpc3 Genes between B6 and D2 Strains.
Yuanjian Chen (779441), Tieqiang Zhao (779440), Yao Sun (145327), Wenyuan Zhao (385511), Fengbo Zhao (779442), Lu Lu (392), Qingqing Gu (338902), Syamal K. Bhattacharya (779443), Robert W. Williams (10394)   +8 more
core   +1 more source

Complementary Yield of Gene Panel Testing and ACMG SF v3.3 Screening for Cardiovascular Disease in a Korean Cohort

Clinical Genetics, EarlyView.
Phenotype‐directed gene panel testing and opportunistic ACMG SF v3.3 screening identified distinct, complementary cardiovascular genetic risks in a Korean cohort. Panel testing achieved a 20.0% yield enriched for arrhythmia/cardiomyopathy genes, whereas opportunistic exome screening revealed a 5.6% yield dominated by TTN‐related cardiomyopathy and ...
Jihye You, Lae‐Young Jung, Sun Hwa Lee, Joonhong Park   +3 more
wiley   +1 more source

Lower left ventricular ejection time in MYBPC3 variant carriers with overt or subclinical hypertrophic cardiomyopathy

ESC Heart Failure
Aims Hypertrophic cardiomyopathy (HCM) is an inherited cardiomyopathy often caused by pathogenic variants in MYBPC3 and MYH7, encoding myosin‐binding protein C3 and myosin heavy chain 7, respectively.
Isabell Yan, Zoe Möhring, Daniel Reichart, Fanny Kortüm, Julia Münch, Rixa Woitschach, Paulus Kirchhof, Lucie Carrier, Carolyn Y. Ho, Thomas Eschenhagen, Monica Patten   +10 more
doaj   +1 more source

High‐resolution spatial transcriptomic atlas of mouse soleus muscle: Unveiling single cell and subcellular heterogeneity in health and denervation

The FEBS Journal, EarlyView.
Seq‐Scope maps skeletal muscle transcriptomes at high spatial resolution while preserving histological context, revealing distinct responses of myofibers, neuromuscular junctions, and stromal cells to denervation. This spatial view uncovers fiber type‐specific and localized remodeling across intact muscle tissue.
Jer‐En Hsu, Lloyd Ruiz, Yongha Hwang, Steve D. Guzman, Chun‐Seok Cho, Weiqiu Cheng, Yichen Si, Peter Macpherson, Angelo Anacleto, Qingyang Zhao, Xiaoya Zhao, Mitchell Schrank, Goo Jun, Hyun Min Kang, Myungjin Kim, Susan V. Brooks, Jun Hee Lee   +16 more
wiley   +1 more source

Whole‐Exome Sequencing Identifies a Rare CSRP3 Variant Associated With Familial Brugada Syndrome in a Lebanese Family

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Introduction Brugada syndrome (BrS) is an inherited arrhythmia associated with an increased risk of sudden cardiac death. Although traditionally regarded as a primary cardiac channelopathy, pathogenic variants in SCN5A account for only 20%–30% of clinically diagnosed cases, leaving most patients genetically unresolved.
Zainab Bashir, Ayat Kadhi, Jad Ballout, Bushra Samara, Maurice Khoury, Georges Nemer, Marwan Refaat   +6 more
wiley   +1 more source

Prenatal ultrasound diagnosis of MYH7 non‐compaction cardiomyopathy [PDF]

Ultrasound in Obstetrics & Gynecology, 2013
AbstractWe report on two prenatal ultrasound diagnoses of left ventricular non‐compaction cardiomyopathy (LVNC) associated with mutation of the cardiac β‐myosin heavy chain gene (MYH7). LVNC is characterized by a trabecular meshwork and deep intertrabecular myocardial recesses communicating with the left ventricular cavity. Clinical features range from
Hoedemaekers, YM, Overbeek, Titia, Mulder, Ingrid, Dooijes, D, Majoor - Krakauer, Danielle   +4 more
openaire   +2 more sources