Results 81 to 90 of about 13,305 (193)

Desmin is not ubiquitously expressed in head and neck muscle fibers

Journal of Anatomy, EarlyView.
Desmin is not ubiquitously expressed in human head and neck muscle fibers. A subset of fibers showed absent or very weak desmin immunoreactivity, with corresponding reduction or absence of desmin mRNA expression. Abstract Desmin, a major muscle‐specific intermediate filament protein, is widely regarded as a ubiquitous component of mature skeletal ...
Per Stål, Jingxia Liu, Fatima Pedrosa Domellöf, Farhan Shah   +3 more
wiley   +1 more source

Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy

, 2013
Familial hypertrophic cardiomyopathy (HCM), frequently caused by sarcomeric gene mutations, is characterized by cellular dysfunction and asymmetric left-ventricular (LV) hypertrophy.
Heymans, Stephane, van der Velden, Jolanda, Hazebroek, Mark, ten Cate, Folkert J., dos Remedios, Cris, Stam, Kelly, Scellini, Beatrice, Tesi, Chiara, Niessen, Hans W. M., Witjas-Paalberends, E. Rosalie, Michels, Michelle, Ferrara, Claudia, Piroddi, Nicoletta, van Dijk, Sabine J., van Slegtenhorst, Marjon, Stienen, Ger J. M., Oliviera, Vasco Sequeira, Poggesi, Corrado, van Dijk, S.J., Piroddi, N., Michels, M., van Slegtenhorst, M., Heymans, S, Stienen, G.J.M., Piroddi, N, van Slegtenhorst, M, Oliviera, V.S., Witjas-Paalberends, E.R., Tesi, C, Ferrara, C., dos Remedios, C, Niessen, H.W.M., Witjas-Paalberends, ER, Tesi, C., Hazebroek, M, Velden, J, Ferrara, C, Niessen, HWM, van der Velden, J., Hazebroek, M., Scellini, B, ten Cate, F.J., Poggesi, C, Scellini, B., dos Remedios, C., Michels, Michelle; id_orcid, Heymans, S., ten Cate, Folkert, Stienen, GJM, van Dijk, SJ, Stam, C.J., Oliviera, VS, Poggesi, C.   +52 more
core   +1 more source

Exploring novel MYH7 gene variants using in silico analyses in Korean patients with cardiomyopathy

BMC Medical Genomics
Background Pathogenic variants of MYH7, which encodes the beta-myosin heavy chain protein, are major causes of dilated and hypertrophic cardiomyopathy. Methods In this study, we used whole-genome sequencing data to identify MYH7 variants in 397 patients ...
Oc-Hee Kim, Jihyun Kim, Youngjun Kim, Soyoung Lee, Beom Hee Lee, Bong-Jo Kim, Hyun-Young Park, Mi-Hyun Park   +7 more
doaj   +1 more source

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Generation of two induced pluripotent stem cell lines from female patients harboring MYH7 mutations with hypertrophic cardiomyopathy

Stem Cell Research
Hypertrophic cardiomyopathy (HCM) is a cardiac disorder marked by left ventricular thickening and impaired diastolic function, often caused by truncating variants in MYH7 gene.
Thulaj Meharwade, Marlies Carlini Weiss, Abdrabu Hamid Ahmed, Lingyun Xu, Victoria N. Parikh, Euan A. Ashley, Joseph C. Wu   +6 more
doaj   +1 more source

A de novo germline mutation in MYH7 causes a progressive dominant myopathy in pigs

BMC Genetics, 2012
Background About 9% of the offspring of a clinically healthy Piétrain boar named ‘Campus’ showed a progressive postural tremor called Campus syndrome (CPS).
Murgiano Leonardo, Tammen Imke, Harlizius Barbara, Drögemüller Cord   +3 more
doaj   +1 more source

A case report of MYH7 mutation-induced restrictive cardiomyopathy

European Heart Journal - Case Reports
Abstract Background Restrictive cardiomyopathy (RCM) is characterized by impaired diastolic function and ventricular filling, often due to genetic and environmental factors. The MYH7 gene, encoding myosin heavy chain in muscle fibres critical for muscle contraction, has been implicated in RCM.
Shaozhen Zhang, Wang Zhao
openaire   +2 more sources

Scapuloperoneal Myopathy and Cardiomyopathy with a Novel MYH7 Mutation: A Case Report [PDF]

, 2020
Introduction: Myosin heavy chain 7 (MYH7)-related myopathies have variable clinical features and onsets and are emerging as a group of muscle diseases that affect a wide range of age groups.
Hooshmand, Sara, Govindarajan, Raghav
core   +1 more source