Results 111 to 120 of about 18,051 (238)

Glucocorticoid receptor alters isovolumetric contraction and restrains cardiac fibrosis [PDF]

, 2017
Corticosteroids directly affect the heart and vasculature and are implicated in the pathogenesis of heart failure. Attention is focussed upon the role of the mineralocorticoid receptor (MR) in mediating pro-fibrotic and other adverse effects of ...
Adrian J W Thomson, Carmel M Moran, Christopher J Kenyon, Cruz-Topete, Darby, Emad A S Al-Dujaili, Emma J Batchen, Eva A Rog-Zielinska, Gillian A Gray, Karen E Chapman, Kathleen Scullion, Mary E Diaz, Oakley, Page, Pirpiris, Rachel V Richardson, Richardson, Rog-Zielinska, Rowan Darroch, Swynghedauw, White, Wiktoria Wyrzykowska, Xinlu Pan   +22 more
core   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs. [PDF]

, 2018
BackgroundPolycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3 Lys27, and plays crucial roles during development and diseases in numerous systems.
He, Yuan, Li, Lili, Tang, Lixu, Wang, Yan, Wang, Yibin, Wang, Zhihua, Xie, Yinping, Yu, Ling, Yu, Pengcheng, Zheng, Di   +9 more
core  

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling [PDF]

, 2015
Distinct stressors may induce heart failure. As compensation, β-adrenergic stimulation enhances myocardial contractility by elevating cardiomyocyte intracellular Ca2+ ([Ca2+]i).
Ann Remme, C. (Carol), Arkenbout, E.K. (Elisabeth Karin), Baartscheer, A. (Antonius), Bleeker, N. (Natascha), Cakici, D. (Daniella), Creemers, E.E. (Esther E.), De Waard, V. (Vivian), Deel, E.D. (Elza) van, Hoogenhof, M.M.G. (Maarten) van den, Medzikovic, L. (Lejla), Meggouh, F. (Farid), Schumacher, C. (Cees), Van Der Made, I. (Ingeborg), Verkerk, A.O. (Arie ), Vries, C.J.M. (Carlie) de, Winter, R.J. (Robbert) de, Wolswinkel, R. (Rianne)   +16 more
core   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Sarcomeric hypertrophic cardiomyopathy: Genetic profile in a Portuguese population

Revista Portuguesa de Cardiologia, 2012
Background: Sarcomeric hypertrophic cardiomyopathy has heterogeneous phenotypic expressions, of which sudden cardiac death is the most feared. A genetic diagnosis is essential to identify subjects at risk in each family.
Dulce Brito, Gabriel Miltenberger-Miltenyi, Sónia Vale Pereira, Doroteia Silva, António Nunes Diogo, Hugo Madeira   +5 more
doaj   +1 more source

Low‐dose lithium supplementation promotes musculoskeletal and metabolic health in ovariectomized female mice

The Journal of Physiology, EarlyView.
Abstract figure legend Low‐dose lithium supplementation in ovariectomized mice enhances skeletal muscle contractility (isometric force and fatigue resistance), SERCA function and promotes favourable transcriptional reprogramming, while increasing bone density and modestly improving insulin sensitivity.
Bianca M. Marcella, Jessica L. Braun, Amélie A.T. Marais, Briana L. Hockey, Mia S. Geromella, Ryan W. Baranowski, Rene Vandenboom, Rebecca E.K. MacPherson, Val A. Fajardo   +8 more
wiley   +1 more source

A case of MYH7 and MYH9 genes variants with cardiomyopathy and macrothrombocytopenia

Clinical Case Reports
Key Clinical Message. A 15‐year‐old girl developed inherited cardiomyopathy and macrothrombocytopenia revealing pathogenic variants of both MYH7 and MYH9 genes.
Yasuhiro Ikawa, Taichi Nakamura, Noboru Fujino, Toru Uchiyama, Akira Ishiguro, Mika Takenaka, Yuta Sakai, Kazuhiro Noguchi, Toshihiro Fujiki, Taizo Wada   +9 more
doaj   +1 more source

MYH7, c.2011C>T, is responsible for congenital scoliosis in a Chinese family

Biochemistry and Biophysics Reports
Neuromuscular scoliosis can be caused by muscular or nervous system dysfunction resulting from genetic variants. Variation in MYH7 may cause hypertrophic or dilated cardiomyopathy, skeletal myopathies, or a combination of both; however, scoliosis has ...
Ping Wei, Fulong Xu, Caixia Xian, Yanhan Liu, Yibo Xu, Ting Zhang, Weizhe Shi, Sihong Huang, Xiang Zhou, Mingwei Zhu, Hongwen Xu   +10 more
doaj   +1 more source