Results 71 to 80 of about 18,051 (238)

A long non-coding RNA protects the heart from pathological hypertrophy [PDF]

, 2014
The role of long noncoding RNA (lncRNA) in adult hearts is unknownalso unclear is how lncRNA modulates nucleosome remodeling. An estimated 70% of mouse genes undergo antisense transcription, including myosin heavy chain 7 (Myh7) that encodes molecular ...
Ashley, Euan, Bernstein, Daniel, Chang, Ching-Pin, Chen, Huei-sheng Vincent, Chen, Peng-Sheng, Chien, Huanchieh, Han, Pei, Jin, Kevin Kai, Li, Wei, Lin, Chieh-Yu, Lin, Chien-Jung, Lin, Chiou-Hong, Nuernberg, Sylvia T., Quertermous, Thomas, Shang, Ching, Xiong, Yiqin, Xu, Weihong, Yang, Jin, Zhou, Bin   +18 more
core   +2 more sources

Genetic Association of Beta-Myosin Heavy-Chain Gene (MYH7) with Cardiac Dysfunction

Genes, 2022
Cardiac dysfunction accelerates the risk of heart failure, and its pathogenesis involves a complex interaction between genetic and environmental factors.
Memoona Yousaf, W. A. Khan, K. Shahzad, H. Khan, Bashar Ali, Misbah Hussain, F. Awan, Hamid Mustafa, F. Sheikh   +8 more
semanticscholar   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Screening of MYH7 gene mutation sites in hypertrophic cardiomyopathy and its significance

Chinese Medical Journal, 2019
. Background:. There have been few reports of mutations in the beta-myosin heavy chain (MYH7) gene in hypertrophic cardiomyopathy (HCM), which is associated with sudden cardiac death caused by HCM.
Hui-Ting Liu, Fang-Fang Ji, Ling Wei, An-Jun Zuo, Yu-Xiu Gao, Lin Qi, Bu Jin, Ji-Gang Wang, Peng Zhao, Ning-Ning Wang   +9 more
doaj   +1 more source

Generation of iPSC line from MYH7 R403L mutation carrier with severe hypertrophic cardiomyopathy and isogenic CRISPR/Cas9 corrected control

Stem Cell Research, 2021
MYH7 is a major gene responsible for hypertrophic cardiomyopathy (HCM). From patient’s skin fibroblasts, we derived an iPSC line (CDGEN1.16) harboring the heterozygous MYH7 R403L mutation, a hot-spot codon in HCM.
Vincent Fontaine, Laetitia Duboscq-Bidot, Charlène Jouve, Matthieu Hamlin, Angélique Curjol, Véronique Briand, Philip Janiak, Jean-Sébastien Hulot, Marie-Pierre Pruniaux-Harnist, Philippe Charron, Eric Villard   +10 more
doaj   +1 more source

Resolving candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analyses [PDF]

, 2012
Peer reviewedPublisher ...
Blizard, David A, Carroll, Andrew M, Derry, Jonathan M J, Lionikas, Arimantas, Meharg, Caroline, Ratkevicius, Aivaras, Vandenbergh, David J   +6 more
core   +2 more sources

Creating Cell‐Based Hybrid Noodles for Sustainable and Nutrient‐Balanced Diets via a Serum‐Free and Animal‐Free 3D Co‐Differentiation System

Advanced Science, EarlyView.
This study develops a 3D co‐culture and co‐differentiation system for porcine muscle stem cells (pMuSCs) and mesenchymal stem cells (pMSCs) on edible starch‐based scaffolds. The system simultaneously generates myotubes and adipocytes without using serum or chemical inducers.
Xin Guan, Luyi Wang, Wanqiang Sun, Yiwei Feng, Dandan Wang, Haohao Tang, Zhenwu Ma, Guocheng Du, Jian Chen, Jingwen Zhou   +9 more
wiley   +1 more source

Reconstructing Coherent Functional Landscape From Multi‐Modal Multi‐Slice Spatial Transcriptomics by a Variational Spatial Gaussian Process

Advanced Science, EarlyView.
This study introduces stVGP, a variational spatial Gaussian process framework for multi‐modal, multi‐slice spatial transcriptomics. By integrating histological and genomic data through hybrid alignment and attention‐based fusion, stVGP reconstructs coherent 3D functional landscapes.
Zedong Wang, Bowen Fu, Chuanchao Zhang, Xiaoping Liu   +3 more
wiley   +1 more source

A heterozygous MYH7 (c. 2156G > A) mutant human induced pluripotent stem cell line (ZZUNEUi020-A) generated from a patient with hypertrophic cardiomyopathy

Stem Cell Research, 2021
Hypertrophic cardiomyopathy (HCM) is a heterogeneous myocardial disease often caused by sarcomeric gene mutations. MYH7 is one of the most common genes associated with HCM.
Xiaowei Li, Wanrong Fu, Guangli Guo, Mengduan Liu, Wenting Du, Jing Zhao, Yangyang Liu, Lu Wang, Jianzeng Dong, Xiaoyan Zhao   +9 more
doaj   +1 more source

MYH7-related myopathies: clinical, myopathological and genotypic spectrum in a multicentre French cohort

Journal of Neurology Neurosurgery & Psychiatry
Background Myosin heavy chain 7 (MYH7)-related myopathies (MYH7-RMs) are a group of muscle disorders linked to pathogenic variants in the MYH7 gene, encoding the slow/beta-cardiac myosin heavy chain, which is highly expressed in skeletal muscle and heart.
Marie Bahout, Gianmarco Severa, Emna Kamoun, F. Bouhour, A. Pégat, Annick Toutain, Emmeline Lagrange, Fanny Duval, C. Tard, Elisa De la Cruz, Léonard Féasson, Agnès Jacquin-Piques, Pascale Richard, C. Métay, Michele Cavalli, N. B. Romero, Teresinha Evangelista, G. Solé, Robert Carlier, P. Laforêt, B. Acket, A. Béhin, G. Fernández-Eulate, S. Léonard-Louis, S. Quijano-roy, Y. Péréon, E. Salort-Campana, A. Nadaj-Pakleza, Marion Masingue, E. Malfatti, Tanya Stojkovic, R. Villar-Quiles   +31 more
semanticscholar   +1 more source