Results 131 to 140 of about 83,456 (310)

Generative Ai for Cardiovascular Cell Type‐Specific Fluorescence Colorization of Live‐Cell hPSC‐Derived Cardiac Organoids

Advanced Intelligent Discovery, EarlyView.
A generative AI system is developed for colorizing phase contrast images of human pluripotent stem cell (hPSC)‐derived cardiac organoids (COs) from bright‐field microscopic imaging using conditional generative adversarial networks (cGANs). By giving these phase contrast images with multichannel fluorescence colorization, this intelligence system ...
Arun Kumar Reddy Kandula, Tanakit Phamornratanakun, Angello Huerta Gomez, Marcel El‐Mokahal, Zhen Ma, Yunhe Feng, Huaxiao Yang   +6 more
wiley   +1 more source

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

Animal Models and Experimental Medicine, EarlyView.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao, Binger Lu, Jinhua Yang, Xiaowan Wang, Shuxian Li, Hongbo Fu, Fenfei Gao   +6 more
wiley   +1 more source

Incidence of major adverse cardiovascular events in patients with rheumatoid arthritis treated with Janus kinase inhibitors compared to biologic disease‐modifying antirheumatic drugs: data from an international collaboration of registries (the "JAK‐pot" study)

Arthritis &Rheumatology, Accepted Article.
Objective To assess the incidence of major adverse cardiovascular events (MACE) in RA patients treated with JAKi, TNF‐inhibitors (TNFi) or biologic Disease‐Modifying Anti‐Rheumatic Drugs with other modes of action (bDMARD‐OMA) in a multi‐country, real‐world population.
Romain Aymon, Denis Mongin, Romain Guemara, Zubeyir Salis, Johan Askling, Denis Choquette, Catalin Codreanu, Daniela Di Giuseppe, Irini Flouri, Doreen Huschek, Kimme L Hyrich, Florenzo Iannone, Tore K Kvien, Burkhard F Leeb, Dan Nordström, Lucia Otero‐Varela, Karel Pavelka, Manuel Pombo‐Suarez, Ana Rodrigues, Ziga Rotar, Prodromos Sidiropoulos, Sella A Provan, Anja Strangfeld, Trokovic Nina, Jakub Zavada, Lianne Kearsley‐Fleet, Delphine S Courvoisier, Axel Finckh, Kim Lauper   +28 more
wiley   +1 more source

Atrial amyloidosis: mechanisms and clinical manifestations

European Journal of Heart Failure, Volume 24, Issue 11, Page 2019-2028, November 2022., 2022
Atrial amyloidosis: pathophysiology and clinical manifestations. Atrial amyloidosis can manifest as part of a systemic disorder (as in amyloid light‐chain [AL] or transthyretin [ATTR] amyloidosis), or be isolated (in the form due to atrial natriuretic type [ANP] accumulation); this last form is often associated with permanent or persistent atrial ...
Giuseppe Vergaro, Alberto Aimo, Claudio Rapezzi, Vincenzo Castiglione, Iacopo Fabiani, Angela Pucci, Gabriele Buda, Claudio Passino, Josep Lupón, Antoni Bayes‐Genis, Michele Emdin, Eugene Braunwald   +11 more
wiley   +1 more source

Myocardial contraction fraction predicts mortality for patients with hypertrophic cardiomyopathy. [PDF]

Sci Rep, 2020
Liao H, Wang Z, Zhao L, Chen X, He S.
europepmc   +1 more source

Recent advances of nanomaterials in imaging liver fibrosis

BMEMat, EarlyView.
Schematic summary on the latest strategies of liver fibrosis imaging based on various nanomaterials. Abstract Liver fibrosis is a pathological process resulting from prolonged exposure to various injury factors. It is characterized by the abnormal proliferation and activation of hepatic stellate cells and excessive deposition of extracellular matrix ...
Jin Cui, Shuxuan Zhang, Xueli Xu, Ke Ren, Mengzhen Dong, Zhaokun Nie, Yang Xu, Xiaohui Dai, Peng Xu, Shuo Sun, Xinya Zhao, Xiao Sun   +11 more
wiley   +1 more source

Right ventricular dysfunction predicts outcome after transcatheter mitral valve repair for primary mitral valve regurgitation

European Journal of Heart Failure, Volume 24, Issue 11, Page 2162-2171, November 2022., 2022
RVD predicts outcome after M‐TEER for PMR. CI, confidence interval; HR, hazard ratio; PMR, primary mitral regurgitation; RVD, right ventricular dysfunction. Abstract Aims Right ventricular dysfunction (RVD), as expressed by right ventricular to pulmonary artery coupling, has recently been identified as a strong outcome predictor in patients undergoing ...
Philipp M. Doldi, Lukas Stolz, Daniel Kalbacher, Benedikt Köll, Martin Geyer, Sebastian Ludwig, Mathias Orban, Daniel Braun, Ludwig T. Weckbach, Thomas J. Stocker, Michael Näbauer, Satoshi Higuchi, Tobias Ruf, Jaqueline Da Rocha e Silva, Mirjam Wild, Noemie Tence, Matthias Unterhuber, Niklas Schofer, Aniela Petrescu, Holger Thiele, Philipp Lurz, Edith Lubos, Stephan von Bardeleben, Nicole Karam, Daryoush Samim, Jean‐Michel Paradis, Christos Iliadis, Erion Xhepa, Christian Hagl, Steffen Massberg, Jörg Hausleiter, on behalf of EuroSMR and PRIME‐MR Investigators, Roman Pfister, Philipp von Stein, Teresa Trenkwalder, Hector Alfonso Alvarez Covarrubias, Sandra Hadjadj, Dounia Rouabhia, Nicolas Brugger, Joanna Bartkowiak   +39 more
wiley   +1 more source

Aminated graphene nanosheet stimulates the maturation of hiPSCs‐derived cardiomyocytes in vitro and enhances their survival in vivo

BMEMat, EarlyView.
Aminated graphene (G‐NH2) niche matrix plays a pivotal role in precisely manipulating cardiac differentiation and maturation of hiPSCs. The molecular mechanism underlying cardiomyocyte maturation is closely linked to the PDGF‐β signaling pathway. Cardiomyocytes derived from the G‐NH2 matrix exhibit enhanced activity and functionality in vivo.
Yin Xu, Xvdong Wang, Zihao Wang, Qi Chen, Donghui Zhang, Nianguo Dong, Jianglin Wang   +6 more
wiley   +1 more source

Myocardial Contraction Fraction is not a Predictor of Clinical Outcomes in Acute Systolic Heart Failure: A Brief Report.

J Cardiovasc Echogr, 2023
Chang AK, Kewcharoen J, Henkel DM, Parwani P, Abramov D.   +4 more
europepmc   +1 more source

Effects of neuropeptide Y on electrical activity and myocardial contractility

Учёные записки Казанского университета: Серия Естественные науки, 2018
Neuropeptide Y (NPY) and agonist Leu(31)Pro(34)NPY were used to determine the type of NPY receptors involved in electrical activity and myocardial contraction.
A.A. Zverev, T.A. Anikina, N.G. Iskakov, A.V. Krulova, P.M. Masliukov, J.P. Timmermans, T.L. Zefirov   +6 more
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