Results 71 to 80 of about 83,934 (252)

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Ischemic preconditioning affects phosphosites and accentuates myocardial stunning while reducing infarction size in rats

Frontiers in Cardiovascular Medicine
Background and aimsIschemic preconditioning (IPC), i.e., brief periods of ischemia, protect the heart from subsequent prolonged ischemic injury, and reduces infarction size. Myocardial stunning refers to transient loss of contractility in the heart after
Ahmed Elmahdy, Ahmed Elmahdy, Aaron Shekka Espinosa, Aaron Shekka Espinosa, Yalda Kakaei, Yalda Kakaei, Tetiana Pylova, Tetiana Pylova, Abhishek Jha, Abhishek Jha, Ermir Zulfaj, Maryna Krasnikova, Maryna Krasnikova, Amin Al-Awar, Amin Al-Awar, Zahra Sheybani, Zahra Sheybani, Valentyna Sevastianova, Valentyna Sevastianova, Evelin Berger, Amirali Nejat, Linnea Molander, Linnea Molander, Erik Axel Andersson, Erik Axel Andersson, Elmir Omerovic, Elmir Omerovic, Shafaat Hussain, Shafaat Hussain, Björn Redfors, Björn Redfors, Björn Redfors   +31 more
doaj   +1 more source

Estradiol Treatment Initiated Early After Ovariectomy Regulates Myocardial Gene Expression and Inhibits Diastolic Dysfunction in Female Cynomolgus Monkeys: Potential Roles for Calcium Homeostasis and Extracellular Matrix Remodeling

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Left ventricular (LV) diastolic dysfunction often precedes heart failure with preserved ejection fraction, the dominant form of heart failure in postmenopausal women.
Kristofer T. Michalson, Leanne Groban, Timothy D. Howard, Carol A. Shively, Areepan Sophonsritsuk, Susan E. Appt, J. Mark Cline, Thomas B. Clarkson, J. Jeffrey Carr, Dalane W. Kitzman, Thomas C. Register   +10 more
doaj   +1 more source

Myocardial contraction fraction predicts mortality in the oldest old. [PDF]

Int J Cardiol Heart Vasc, 2022
Leibowitz D, Bishara Y, Stessman-Lande I, Hammerman-Rosenberg A, Jacobs JM, Gilon D, Stessman J.   +6 more
europepmc   +1 more source

Enhancing Blood Circulation With Epsilon‐Near‐Zero (ENZ) Materials via the Far‐Infrared Window of Human Skin

Advanced Science, EarlyView.
Epsilon‐near‐zero (ENZ) silicon carbide enables a selective far‐infrared emitter spectrally aligned with the human skin window around 10 µm for wavelength‐matched thermal therapy. In 25 within‐subject trials (50 hands) monitored by laser speckle contrast imaging, SiC increases blood perfusion by 30.2% versus a broadband graphite emitter while ...
Wen‐Teng Yao, Shan‐Chiao Yang, Ming‐Feng Tsai, Hsuen‐Li Chen   +3 more
wiley   +1 more source

Mechanism of inhibiting acetyl CoA carboxylase 2 to improve cardiac dysfunction in septic mice

陆军军医大学学报
Objective To observe the ameliorative effect of inhibiting acetyl-CoA carboxylase 2(ACC2) on cardiac dysfunction in septic mice and investigate its underlying mechanism.
DU Yunxia, DU Yunxia, SHE Han, SHE Han, WU Yinyu   +4 more
doaj   +1 more source

Contratura isquêmica do miocárdio: estudo experimental em ratos

Brazilian Journal of Cardiovascular Surgery, 1997
A contratura isquêmica do miocárdio (CIM) tem sido muito utilizada na investigação da fisiopatologia da isquemia global do coração. Este trabalho descreve um modelo experimental adequado ao estudo da CIM, em ratos.
Eduardo Tiveron VELUDO, Alexandre Luiz ARANHA, Alexandre PACCHIONI, Gustavo Ribeiro de OLIVEIRA, Albert Amin SADER, Yvone Avalloni de Moraes V. A. VICENTE, Walter V. A. VICENTE   +6 more
doaj   +1 more source

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

Advanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li, Jialuo Xu, Gaoyuan Du, Xiangting Jia, Dongmin Zhao, Chunyan Zhou, Kexin Xiao, Jia Gu, Junnan Zhu, Xuequn Shang   +9 more
wiley   +1 more source

Stroke volume and myocardial contraction fraction in transthyretin amyloidosis cardiomyopathy: A systematic review. [PDF]

Front Cardiovasc Med, 2023
Matteo S, Anna C, Federico S, Daniele M, Gioele F, Beatrice DP, Rita P, Elisabetta T, Giulia P, Claudio R, Gianluca C.   +10 more
europepmc   +1 more source

All‐Flex Plasma Patch for In Vivo Delivery of Reactive Species

Advanced Science, EarlyView.
A fully flexible plasma patch enables stable, conformal treatment on complex biological surfaces and enhances transdermal delivery of reactive species. This platform achieves significant tumor suppression in vivo and reveals coordinated regulation of calcium signaling, metabolism, and programmed cell death, providing a promising strategy for safe and ...
Luxiang Zhao, Abulaihaiti Tuergong, Hanshu Yang, Shuang Xue, An Yan, Mingzhen Wang, Weilong Song, Wenzhe Si, Ruixue Wang   +8 more
wiley   +1 more source