Results 81 to 90 of about 83,934 (252)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Coronary Artery Spasm: From Physiopathology to Diagnosis

Life
Coronary artery spasm (CAS) is a reversible vasoconstriction of normal or atherosclerotic epicardial coronary arteries with a subsequent reduction in myocardial blood flow, leading to myocardial ischemia, myocardial infarction, severe arrhythmias, or ...
Ilinca Savulescu-Fiedler, Radu Octavian Baz, Radu Andrei Baz, Cristian Scheau, Andrei Gegiu   +4 more
doaj   +1 more source

Quantification of Myocardial Contraction Fraction with Three-Dimensional Automated, Machine-Learning-Based Left-Heart-Chamber Metrics: Diagnostic Utility in Hypertrophic Phenotypes and Normal Ejection Fraction. [PDF]

J Clin Med, 2023
Barbieri A, Imberti JF, Bartolomei M, Bonini N, Laus V, Torlai Triglia L, Chiusolo S, Stuani M, Mari C, Muto F, Righelli I, Gerra L, Malaguti M, Mei DA, Vitolo M, Boriani G.   +15 more
europepmc   +1 more source

Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System

Advanced Electronic Materials, EarlyView.
This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella, Katelyn Neuman, Nolan Burson, Abigail N. Koppes, Ryan A. Koppes   +4 more
wiley   +1 more source

Morfologia e contratilidade em cardiomiócitos de ratos com baixo desempenho para o exercício físico Morphology and contractility in cardiomyocytes of rats with low exercise performance

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: A capacidade aeróbica é fundamental para o desempenho físico, e a baixa capacidade aeróbica está relacionada ao desencadeamento de diversas doenças cardiovasculares.
Judson Fonseca Quintão Júnior, Antônio José Natali, Miguel Araújo Carneiro Júnior, Cynthia Aparecida de Castro, Lucas Rios Drummond, Victor Neiva Lavorato, Leonardo Bonato Felix, Jader dos Santos Cruz, Thales Nicolau Prímola-Gomes   +8 more
doaj  

Myocardial Contraction Fraction is Superior to Ejection Fraction in Predicting Functional Capacity in Patients with Heart Failure with Reduced Ejection Fraction. [PDF]

J Saudi Heart Assoc, 2022
Abdellatif YA, Addow HA, Elias RR.
europepmc   +1 more source

Chronic Disease Monitoring Using Advanced Compliant Materials for Bioelectronics

Advanced Electronic Materials, EarlyView.
Compliant bioelectronic systems enable continuous monitoring of chronic disease through soft, stretchable materials and tissue‐conformal designs that support stable electrophysiological, mechanical, and biochemical sensing. Integration of diverse sensing modalities with thoughtful material selection, device architectures, and advanced fabrication ...
Han Kim, Mabel Bartlett, Liyang Wang, Karl Bates, Mengdi He, Myungbo Kim, Carmel Majidi, Tzahi Cohen‐Karni   +7 more
wiley   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source

Synchronous force and Ca2+ measurements for repeated characterization of excitation-contraction coupling in human myocardium

Communications Biology
Dysfunctional Ca2+ signaling affects the myocardial systole and diastole, may trigger arrhythmia and cause transcriptomic and proteomic modifications in heart failure.
Zhengwu Sun, Kun Lu, Christine Kamla, Petra Kameritsch, Thomas Seidel, Andreas Dendorfer   +5 more
doaj   +1 more source

Editorial: Mechano-Calcium, Mechano-Electric, and Mechano-Metabolic Feedback Loops: Contribution to the Myocardial Contraction in Health and Diseases. [PDF]

Front Physiol, 2021
Peyronnet R, Solovyova O, Iribe G, Katsnelson LB.   +3 more
europepmc   +1 more source