Results 61 to 70 of about 318,281 (264)

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

MYOCARDIAL DYSFUNCTION IN SEPSIS PATIENTS

Вестник анестезиологии и реаниматологии, 2018
Goal of the study: to study the frequency of myocardial dysfunction in sepsis patients and its impact on the outcome of the disease. Materials and Methods. 177 sepsis patients were enrolled into the retrospective cohort study.
L. L. Plotkin, M. Yu. Rakhmanov, V. V. Kutubulatov   +2 more
doaj   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Pathophysiology and Imaging Techniques of Diabetic Heart Disease [PDF]

European Medical Journal Diabetes, 2014
Diabetic patients are at an increased risk of developing heart failure. The aetiology of diabetic heart disease is likely to be multifactorial, ranging from altered myocardial metabolism, increased interstitial fibrosis, endothelial dysfunction ...
Danielle L. Harrop, William Y.S. Wang, Arnold C.T. Ng   +2 more
doaj  

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Sepsis-Induced Myocardial Depression and Takotsubo Syndrome

Türk Yoğun Bakim Derneği Dergisi, 2015
Sepsis induced temporary myocardial dysfunction characterized as impairment of myocardial contraction is an important cause of mortality and morbidity in intensive care units.
Mustafa Kemal Arslantaş, Gülbin Töre Altun, İsmail Cinel   +2 more
doaj   +1 more source

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Septic Cardiomyopathy

Reviews in Cardiovascular Medicine
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis-induced myocardial dysfunction represents reversible myocardial dysfunction which ultimately results in left ventricular dilatation or ...
Ivana Lukić, Damir Mihić, Silvija Canecki Varžić, Kristina Selthofer Relatić, Lada Zibar, Domagoj Loinjak, Željka Breškić Ćurić, Lucija Klobučar, Lana Maričić   +8 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

2016 ESC POSITION PAPER ON CANCER TREATMENTS AND CARDIOVASCULAR TOXICITY DEVELOPED UNDER THE AUSPICES OF THE ESC COMMITTEE FOR PRACTICE GUIDELINES

Российский кардиологический журнал, 2017
The Task Force for cancer treatments and cardiovascular toxicity of the European Society of Cardiology (ESC).
Editorial article
doaj   +1 more source