Results 141 to 150 of about 218,133 (348)

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Imaging, biomarker and invasive assessment of diffuse left ventricular myocardial fibrosis in atrial fibrillation [PDF]

, 2020
Gordon A. Begg, Peter Swoboda, Rashed Karim, Tobias Oesterlein, Kawal Rhode, Arun V. Holden, John P. Greenwood, Eduard Shantsila, Gregory Y.H. Lip, Sven Plein, Muzahir H. Tayebjee   +10 more
openalex   +1 more source

Isovolumic relaxation strain imaging is an accurate and sensitive approach for detection of active diastolic dysfunction: A preclinical study

Animal Models and Experimental Medicine, EarlyView.
A modified approach was developed to accurately identify the isovolumetric relaxation time (IVRT) using an apical three‐chamber view. Compared with conventional echocardiography, isovolumic relaxation strain imaging (IVSI) helps to detect the earlier alternations of diastolic function in transverse aortic constriction (TAC) mice.
Jingjing Liang, Juncheng Wang, Jun Cheng, Yanggan Wang   +3 more
wiley   +1 more source

Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy

Reviews in Cardiovascular Medicine
Dilated cardiomyopathy (DCM) is the ultimate manifestation of the myocardial response to various genetic and environmental changes and is characterized mainly by impaired left ventricular systolic and diastolic function.
Xin-Yi Feng, Yu-Cong Zheng, Ying-Xia Yang, Wen-Feng He, Fan Yang, Ling-Li Wang, Han-Feng Yang, Chun-Ping Li, Xiao-Xue Xu, Rui Li   +9 more
doaj   +1 more source

Diastolic Dysfunction in Hypertensive Hearts: Roles of Perivascular Inflammation and Reactive Myocardial Fibrosis [PDF]

, 2005
Hisashi Kai, Fumitaka Kuwahara, Keisuke Tokuda, Tsutomu Imaizumi   +3 more
openalex   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Morphological and electrocardiographic criteria for myocardial fibrosis and atrial fibrillation

Известия высших учебных заведений. Поволжский регион: Медицинские науки
Background. The formation of myocardial fibrosis is the leading mechanism for occurrence of atrial fibrillation. In this regard, an attempt to prevent development of myocardial fibrosis and its treatment is pathogenetically expedient.
R.E. Dementeva, F.K. Rakhmatullov, A.E. Sheina, A.V. Baranov, A.M. Bibarsova   +4 more
doaj   +1 more source

Age and gender effects on echocardiographic and histopathological cardiac phenotypes in healthy adult mice

Animal Models and Experimental Medicine, EarlyView.
This study investigated the impact of age and sex on cardiac phenotypes in healthy adult C57BL/6J mice using echocardiography and histopathological analyses. Findings revealed that female mice demonstrated more pronounced global cardiac chamber dilation during aging.
Shuang Wen, Xijia Shao, Xiulin Zhang, Ningning Zhang, Xiao Chen, Guangxin Yue, Jiangping Song   +6 more
wiley   +1 more source

Effects of Empagliflozin and Dapagliflozin in alleviating cardiac fibrosis through SIRT6-mediated oxidative stress reduction

Scientific Reports
Sodium-glucose co-transport protein 2 (SGLT2) inhibitors, a novel category of oral hypoglycemic agents, offer a promising outlook for individuals experiencing heart failure with reduced ejection fraction.
Hong-xia Ma, Ke Wu, Fei-hong Dong, Bing-kun Cai, Di Wu, Hui-yi Lu   +5 more
doaj   +1 more source

Hypertension Myocardial Fibrosis [PDF]

The Journal of Clinical Hypertension, 2007
openaire   +2 more sources